Radiosurgery for treatment of brain metastases: Estimation of patient eligibility using three stratification systems

Lorenzoni, José; Devriendt, Daniel; Massager, Nicolas; David, P.; Ruiz, S. Hidalgo; Vanderlinden, Bruno; Houtte, Paul Van; Brotchi, Jacques; Levivier, Marc

doi:10.1016/j.ijrobp.2004.02.017

Cited by 272 publications

(224 citation statements)

References 33 publications

(35 reference statements)

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“…In this case also the site's experience was compared with the results published by other authors [1,5,13,14,37,40,46]. Some investigators point to the adverse prognostics significance of the presence of metastases outside the brain, in particular in the lungs, liver, spleen and adrenal glands, and, to a lesser degree, in the bones, lymph nodes and skin [5,6,8,30,31,[33][34][35][40][41][42]. In the site's own material, in a single-variance analysis, it was shown that the co-existence of the metastases in extracranial locations was an adverse prognostic factor, which was, however, not confirmed by the results of the multivariance analysis.…”

Section: Discussionmentioning

confidence: 86%

“…The published data definitively indicate the prognostic value of KPS; in the majority of publications, the statistically significant adverse prognostic factor is a KPS below 70 [5-8, 14, 16, 17, 30, 32-36], whilst in other publications, this concerns a KPS below 80 [7,32,33]. Table VI presents the values of average survival periods of patients with MBM depending on the KPS score, which were 5.9-6.3 months for KPS ≥ 70 and were definitely lower in patients with a poorer general performance (KPS < 70), where they varied from 1.8 to 3.8 months.…”

Section: Discussionmentioning

confidence: 99%

“…There have been many publications with prognostic indexes for patients with brain metastases of various types of cancers: RPA-RTOG (Recursive Partitioning Analysis -Radiation Therapy Oncology Group), Rotterdam, SIR (Score Index for Radiosurgery), BSBM (Basic Score for Brain Metastases), Rades et al score, GPA (Graded Prognostic Assessment), MM-GKR (Malignant Melanoma -Gamma Knife Radiosurgery), MS-GPA (melanoma-specific GPA) [30][31][32][33][34][35][36].…”

Section: Introductionmentioning

confidence: 99%

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The effectiveness of brain metastases radiotherapy in patients with melanoma

Szyszka-Charewicz

2017

Nowotwory. Journal of Oncology

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Introduction. Melanoma gives rise to 7-13% brain metastases (MBM -melanoma brain metastases) and is ranked third leading cause of brain metastases. The prognosis of patients with MBM is poor, with a median survival time of 3-6 months. Assessment of the value and limitations of three prognostic scores used in patients with melanoma brain metastases (MBM) was presented in this paper. Material and methods. In 110 patients with MBM, we executed an analysis of prognostic factors. All patients were treated with radiotherapy: whole brain radiotherapy performed as a treatment method in combination with chemotherapy (14 patients -12.7%), neurosurgery (12 patients -10.9% or stereotactic radiosurgery (8 patients -7.3%). Results. The median overall survival (OS) from diagnosis MBM was 4.8 months (95% CI 4.1-5.2 months). The analyses showed that the Karnofsky Performance Status and number of the MBM are independent significant prognostic factors. The analyses of OS, as a function of prognostic scores, showed that in the class with the best prognosis median OS was similar (7.2-10.7 months); and in the class with the worse prognosis median OS was also similar (range, 2.6-4.3 months). Conclusions. Our observations and data from literature showed that the presented scores can: distinguish classes of patients by prognosis before treatment, guide the choice of treatment methods and help design strategies for patient selection in clinical trials but they did not fully discriminate between unfavourable groups. NOWOTWORY J Oncol 2016; 66, 5: 367-374

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Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The effectiveness of brain metastases radiotherapy in patients with melanoma

Szyszka-Charewicz

2017

Nowotwory. Journal of Oncology

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“…Positive influence of controlled primary site has been reported in multivariate study (Sneed, 2002) and in univariate studies (Lorenzoni, 2004;Jawahar, 2004;Pan, 2005;Kased, 2009). Some studies did not find significant influence (Chidel, 2000;Hernández, 2002;Golden, 2008).…”

Section: Control Of the Primary Tumormentioning

confidence: 77%

“…No influence on survival of the primary tumor have been reported (Lorenzoni, 2004;Nam, 2005;Rades, 2007;Frazier, 2010), on the other hand other studies have demonstrated significant association of this variable with survival: Hasegawa (Hasegawa, 2003), in the multivariate analysis found significant lower survival in patients harboring malignant melanoma. In multivariate studies Simonová (Simonová, 2000) reported better survival in patients with breast or renal cancer, Petrovich (Petrovich, 2002) found worse survival in patients with Melanoma and colon cancer and better survival in patients with breast cancer.…”

Section: Location or Histology Of The Primary Tumormentioning

confidence: 90%