Radiosurgery for brain metastases: who may not benefit?

Weltman, Eduardo; Salvajoli, João Víctor; Brandt, Reynaldo André; Hanriot, Rodrigo de Morais; Prisco, Flavio E.; Cruz, José C.; Borges, Sandra Regina de Oliveira; Lagatta, Mônica; Wajsbrot, Dalia

doi:10.1016/s0360-3016(01)01696-0

Cited by 30 publications

(19 citation statements)

References 33 publications

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“…Single metastases were not prognostic in the RTOG RPA classification, either. It is in contrast with the findings of more recent data [14,18,19]. It could be explained by the use of unreliable diagnostic tools in earlier data, like ours, namely CT instead of MRI, which is inappropriate in the evaluation of the real extent of disease in the CNS.…”

Section: Discussioncontrasting

confidence: 95%

“…Other studies found age with cut-off of 60 [11,19,23] or 70 years [2] as an independent prognostic factor. Reliable evaluation of extracranial disease is not possible to perform in the retrospective manner.…”

Section: Discussionmentioning

confidence: 94%

“…For patients initially managed with conservative treatment, control of the primary was defined as a complete tumour response or a lack of local progression for at least 6 months before WBRT. BM were defined as synchronous, if they appeared before or [19], when the authors tried to better define prognostic factors for patients with BM treated by aggressive methods.…”

Section: Methodsmentioning

confidence: 99%

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Results of the whole-brain radiotherapy for patients with brain metastases from lung cancer: The RTOG RPA intra-classes analysis.

et al. 2005

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(2005) Results of the whole-brain radiotherapy for patients with brain metastases from lung cancer: The RTOG RPA intra-classes analysis., Acta Oncologica, 44:4,[389][390][391][392][393][394][395][396][397][398] AbstractWe evaluated the overall survival with respect to prognostic factors in patients with brain metastases (BM) from lung cancer in order to assess the RTOG RPA (Recursive Partitioning Analysis) classification value and to perform intra-classes analyses including pretreatment and treatment-related variables. Between 1986 and 1997, 322 consecutive patients with BM from lung cancer were treated with whole-brain radiotherapy. Patients' distribution according to the RTOG RPA classes was: Class 1 Á/ 13%, Class 2 Á/ 67% and Class 3 Á/ 20%. Prognostic value of the following variables was tested: RTOG RPA classes, performance status, age, extracranial metastases, control of the primary tumour, gender, histology, number of BM and interval from diagnosis to the development of BM. Intra-classes analyses were performed including radiation dose and surgery of BM. Median survival was 4.0 months. Median survival for RTOG RPA classes 1, 2 and 3 were 5.2, 4.0 and 2.5 months, respectively (p 0/0.003). Extracranial metastases, performance status, control of the primary and RTOG RPA classes were prognostic for survival. Within class 2 higher radiation dose, female, no extracranial metastases and surgery of BM were related to the improved survival. RTOG RPA classes maintain their prognostic significance for patients with BM from lung cancer not participating in clinical trials.

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Section: Discussioncontrasting

confidence: 95%

Section: Discussionmentioning

confidence: 94%

Section: Methodsmentioning

confidence: 99%

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Results of the whole-brain radiotherapy for patients with brain metastases from lung cancer: The RTOG RPA intra-classes analysis.

et al. 2005

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“…The "Score index for radiosurgery in brain metastases" (SIR) was described by Weltman (Weltman, 2000;Weltman, 2001) and validated afterwards (Lorenzoni, 2004). It uses five prognostic factors: Age, Karnofsky, systemic disease status, the size and the number of lesions (table 2).…”

Section: Score Index For Rradiosurgery In Brain Metastases (Sir)mentioning

confidence: 99%

Gamma Knife Treatment for Patient Harboring Brain Metastases: How to Estimate Patient Eligibility and Survival?

Lorenzoni¹,

Zarate²,

Ramón³

et al. 2011

Gamma Knife Radiosurgery

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“…The patients of group B (n = 16) The fractionation schedules were selected, because the prognosis of our patients was expected to be comparably good [21]. Studies comparing different fractionation schedules of WBRT ranging from 10 Gy/one fraction to 40 Gy/20 fractions did not reveal any specific schedule to be superior to others for local control and overall survival [3].…”

Section: Introductionmentioning

confidence: 99%