Radiosterilization of sulfonamides: I: determination of the effects of gamma irradiation on solid sulfonamides

Mercanoğlu, Güldem; Özer, A. Yekta; Çolak, Şeyda; Korkmaz, Mustafa; Özalp, Meral; Ekizoğlu, Melike; Barbarin, Nicolas; Tilquin, Bernard

doi:10.1016/j.radphyschem.2003.09.005

Cited by 18 publications

(13 citation statements)

References 14 publications

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“…The unchanged color of irrigants and nonappearance of sediments or precipitation following the exposure to e-beam radiation on day1 and after 180 d storage at 4 o C illustrates the absence of radiolytic compounds in irradiated dental irrigants. The findings of the present study are in accordance with the published report which illustrated no change in the pH of irradiated sulphonamide [20]. However, the earlier study demonstrated the formation of free radicals by analogs of anthracycline followed by e-beam irradiation at 25 kGy [21].…”

Section: Discussionsupporting

confidence: 93%

Antimicrobial Activity and Stability of Electron Beam Irradiated Dental Irrigants

Geethashri

et al. 2014

JCDR

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Section: Discussionsupporting

confidence: 93%

Antimicrobial Activity and Stability of Electron Beam Irradiated Dental Irrigants

Geethashri

et al. 2014

JCDR

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“…Gamma irradiation has becoming an alternative sterilization method for the pharmaceutical industry, recently [2]. Also, it has turned out to be an interesting and promising technique for drug delivery systems like liposomes [3][4], which are defi ned as lipid bilayer vesicles that can encapsulate drugs either in aqueous compartment or inside of the lipid bilayer and transport them to the cells effi ciently [5]. Nowadays, gamma irradiation is used to sterilize and/or decontaminate several pharmaceuticals, raw materials and fi nished products successfully [4][5][6][7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

“…Also, it has turned out to be an interesting and promising technique for drug delivery systems like liposomes [3][4], which are defi ned as lipid bilayer vesicles that can encapsulate drugs either in aqueous compartment or inside of the lipid bilayer and transport them to the cells effi ciently [5]. Nowadays, gamma irradiation is used to sterilize and/or decontaminate several pharmaceuticals, raw materials and fi nished products successfully [4][5][6][7][8][9][10][11]. Diff erent sterilization techniques have been used and reviewed for liposomes by Zuidam et al [12], however, there is still an unsolved problem for the irradiation process which causes radiolytic products [13].…”

Section: Introductionmentioning

confidence: 99%

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The effects of gamma irradiation on diclofenac sodium, liposome and niosome ingredients for rheumatoid arthritis

Özer¹,

Türker

Çolak

et al. 2013

Interventional Medicine and Applied Science

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Abstract:The use of gamma rays for the sterilization of pharmaceutical raw materials and dosage forms is an alternative method for sterilization. However, one of the major problems of the radiosterilization is the production of new radiolytic products during the irradiation process. Therefore, the principal problem in radiosterilization is to determine and to characterize these physical and chemical changes originating from high-energy radiation. Parenteral drug delivery systems were prepared and in vitro characterization, biodistribution and treatment studies were done in our previous studies. Drug delivery systems (liposomes, niosomes, lipogelosomes and niogelosomes) encapsulating diclofenac sodium (DFNa) were prepared for the treatment of rheumatoid arthritis (R A). This work complies information about the studies developed in order to fi nd out if gamma radiation could be applied as a sterilization method to DFNa, and the raw materials as dimyristoyl phosphatidylcholine (DMPC), surfactant I [polyglyceryl-3-cethyl ether (SUR I)], dicethyl phosphate (DCP) and cholesterol (CHOL) that are used to prepare those systems. The raw materials were irradiated with diff erent radiation doses (5, 10, 25 and 50 kGy) and physicochemical changes (organoleptic properties pH, UV and melting point), microbiological evaluation [sterility assurance level (SAL), sterility and pyrogen test] and electron spin resonance (ESR) characteristics were studied at normal (25 °C, 60% relative humidity) and accelerated (40 °C, 75% relative humidity) stability test conditions.

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“…Gamma irradiation is an approved sterilization technique for some pharmaceuticals [2][3][4][5][6][7][8][9][10] and has turned out to be an interesting and promising technique also for the sterilization of liposomes. Zuidam et al [11] have published a review of the diff erent sterilization techniques for liposomes, and they concluded that gamma irradiation can be accepted as a safe and convenient sterilization technique for liposomes, and more studies are necessary.…”

Section: Introductionmentioning

confidence: 99%

Gamma-irradiated liposome/niosome and lipogelosome/niogelosome formulations for the treatment of rheumatoid arthritis

Türker

Özer

Kılıç

et al. 2013

IMAS

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Treatment of rheumatoid arthritis by intraarticular administration of anti-infl ammatory drugs encapsulated in drug delivery systems, such as liposomes/niosomes and lipogelosomes/niogelosomes, prolongs the residence time of the drugs in the joint. It was therefore anticipated that liposome/niosome entrapment would enhance the effi cacy of drugs in the infl ammatory sides. Liposomes are good candidates for the local delivery of therapeutic agents, such as diclofenac sodium (DFNa), for intraarticular delivery. Drugs for parenteral delivery must be sterile, and radiation sterilization is a method recognized by pharmacopoeias to achieve sterility of drugs. However, irradiation might also aff ect the performance of drug delivery systems. One of the most critical points is irradiation dose, because certain undesirable chemical and physical changes may accompany with the treatment, especially with the traditionally applied dose of 25 kGy. The present study aims to determine the eff ects of gamma irradiation on DFNa-loaded liposomes/niosomes and lipogelosomes/niogelosomes for the treatment of rheumatoid arthritis.

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Radiosterilization of sulfonamides: I: determination of the effects of gamma irradiation on solid sulfonamides

Cited by 18 publications

References 14 publications

Antimicrobial Activity and Stability of Electron Beam Irradiated Dental Irrigants

Antimicrobial Activity and Stability of Electron Beam Irradiated Dental Irrigants

The effects of gamma irradiation on diclofenac sodium, liposome and niosome ingredients for rheumatoid arthritis

Gamma-irradiated liposome/niosome and lipogelosome/niogelosome formulations for the treatment of rheumatoid arthritis

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