Radiosensitization with low-dose carboplatin enhances pain palliation in radioisotope therapy with strontium-89

Internal radiotherapy of painful bone metastases

“…Bone disease progression was observed in 27% of patients in arm A and in 64% of patients in arm B (p = 0.01). A former study [205] documented a significant higher pain relief for patients with 89 Sr and 100 mg/m 2 carboplatin versus 89 Sr.…”

Bone Seeking Radiopharmaceuticals for Metastatic Bone Pain

“…Level 2 A2 (Sciuto et al 2002) C (Sciuto et al 1996) It has been suggested that adding 89 SrChloride to chemotherapy may lead to improved survival and a longer duration of the pain response compared to treatment with chemotherapy alone.…”

“…Another combined treatment regimen would be a combination of bone seeking radiopharmaceuticals and chemotherapy. It is likely that combined treatment with 89 SrChloride and chemotherapy (platinum based) yields a better pain response than treatment without chemotherapy in patients with painful osseous metastases from a prostate carcinoma (Sciuto et al 2002), (Sciuto et al 1996). And it has been suggested that adding 89 Sr-Chloride to chemotherapy may lead to improved survival and a longer duration of the pain response compared to treatment with chemotherapy alone (Tu et al 2001).…”

Complete regression of multiple painful bone metastases from hepatocellular carcinoma after administration of strontium-89 chloride

“…Pain relief is achieved in 58-82% of patients with prostate or breast cancer bone metastasis [3,4]. The analgesic effects depend on the type of metastasis.…”

“…Recently, strontium-89 chloride ( 89 SrCl 2 ) has become to be used as a palliative therapeutic option to relieve pain from bone metastases, even with multiple bone lesions [3,4]. Its usefulness in relieving pain in patients with breast and prostate cancer has been established, but few reports have described the clinical utility of 89 SrCl 2 therapy in patients with painful bone metastasis from HCC [5,6].…”