Radiosensitization of paclitaxel, etanidazole and paclitaxel+etanidazole nanoparticles on hypoxic human tumor cells in vitro

Jin, Cheng; Bai, Ling; Wu, Hong; Tian, Furong; Guo, Guozhen

doi:10.1016/j.biomaterials.2007.04.032

Cited by 63 publications

(39 citation statements)

References 28 publications

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“…In the previous work, we reported the radiosensitizing effect of paclitaxel-loaded nanoparticles on hypoxic tumor cells (41)(42)(43). Nevertheless, to our knowledge there are no studies on the literature regarding the cytotoxicity of paclitaxel-loaded nanoparticles on hypoxic tumor cells.…”

Section: Introductionmentioning

confidence: 87%

Cytotoxicity of Paclitaxel Incorporated in PLGA Nanoparticles on Hypoxic Human Tumor Cells

Jin

Bai

et al. 2009

Pharm Res

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Section: Introductionmentioning

confidence: 87%

Cytotoxicity of Paclitaxel Incorporated in PLGA Nanoparticles on Hypoxic Human Tumor Cells

Jin

Bai

et al. 2009

Pharm Res

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“…It is becoming clear that the therapeutic effects of drug-loaded nanoparticles would depend on internalization and sustained retention of the nanoparticles by diseased cells. [18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] Fluorescence uptake by C6 cells could be a useful model for assessing the in vitro therapeutic effect of various docetaxel formulations for brain cancer. As shown in Table 1, the coumarin 6-loaded nanoparticles used for cellular uptake research were highly relevant to the docetaxel-loaded nanoparticles in terms of their size and zeta potential.…”

Section: Uptake Of Coumarin 6-loaded Nanoparticles By C6 Cellsmentioning

confidence: 99%

Novel docetaxel-loaded nanoparticles based on PCL-Tween 80 copolymer for cancer treatment

Zheng²,

Zeng³

et al. 2011

IJN

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Two types of nanoparticle formulation were made from commercial PCL and a self-synthesized PCL-Tween 80 copolymer using a modified solvent extraction/evaporation method. Results: The nanoparticles were found by field emission scanning electron microscopy to have a spherical shape and be 200 nm in diameter. The copolymers could encapsulate 10% of the drug in the nanoparticles and release 34.9% of the encapsulated drug over 28 days. PCL-Tween 80 nanoparticles could be internalized into the cells and had higher cellular uptake than the PCL nanoparticles. The drug-loaded PCL-Tween 80 nanoparticles showed better in vitro cytotoxicity towards C6 cancer cells than commercial Taxotere at the same drug concentration. Conclusion: Nanoparticles using PCL-Tween 80 copolymer as drug delivery vehicles may have a promising outcome for cancer patients.

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“…The polymer bound nitroimidazoles compounds such as metronidazoles, etanidazoles, tinidazoles have been found useful as hypoxia markers in tumors [5,18,23]. Nitroimidazole polymer complexes as hydrogels, beads used as colon targeted drug delivery systems is emerging [1,3,6,11,13,14,15,17,22].…”

Section: Discussionmentioning

confidence: 99%

Newer Methods of Nanoparticle Synthesis: Nitroimidazole properties with Nanometal oxides in Polymer Cages as Drug-Biomarker Monitors

Sharma

2009

Nat Prec

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Nitroimidazoles are radiosensitizers and hypoxia detecting chemosensitizers. Intially nitroimidazoles were single dose antibiotic drugs. Recently, nitroimidazole derivatives have emerged as multifunctional "drug-biomarker monitors" chemical compounds with importance in treatment of tumors, monitoring hypoxia and safer imaging contrast agents to monitor the therapeutic progress. Additionally, the number of nitroimidazole derivatives is growing and identified their importance as multifunctional nanoparticles. The nanoparticle synthesis scheme of nitroimidazole was proposed as nitroimidazole caged with metal oxide inside polymer coating and labeled with marker biomolecules. We report the step by step user-friendly new co-precipitation schemes of nitroimidazole carrier nanoparticles with their mechanisms of drug controlled release behavior, metal oxide sensitivity to imaging modalities and polymer coating chemistry developed at our lab. The multifunctional nitroimidazole nanoparticles were useful in detection and monitoring of hypoxia, cancer chemotherapy and soft tissue infections. In conclusion, nitroimidazoles are potential multifunctional molecules useful in chemotherapy, antiparasitic and monitoring hypoxia with greater possibility of simultaneous use of radiolabeled 2'nitroimidazoles as radiosensitizers, MRI-PET-US contrast imaging agents.

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Radiosensitization of paclitaxel, etanidazole and paclitaxel+etanidazole nanoparticles on hypoxic human tumor cells in vitro

Cited by 63 publications

References 28 publications

Cytotoxicity of Paclitaxel Incorporated in PLGA Nanoparticles on Hypoxic Human Tumor Cells

Cytotoxicity of Paclitaxel Incorporated in PLGA Nanoparticles on Hypoxic Human Tumor Cells

Novel docetaxel-loaded nanoparticles based on PCL-Tween 80 copolymer for cancer treatment

Newer Methods of Nanoparticle Synthesis: Nitroimidazole properties with Nanometal oxides in Polymer Cages as Drug-Biomarker Monitors

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