Radiosensitivity enhancement of Fe₃O₄@Ag nanoparticles on human glioblastoma cells

Abstract

Radiotherapy is one of the main therapeutic methods for cancers, but radiation resistance of cancer cells still remains a serious concern. Searching for radiosensitizers to overcome such resistance is therefore urgently required. The goal of this study is to evaluate and compare the radiosensitizing efficacy of FeO-OA, Ag and FeO@Ag nanoparticles on U251 cells. The results show that FeO@Ag nanoparticles have the highest ability of radiosensitization among the three nanoparticles. The underlying mechanism of FeO@Ag nanoparticles' radiosensitivity enhancement is through decrease of the cytoprotective autophagy at the early stage, and increase of the calcium-dependent apoptosis at the later stage. These findings suggest the potential application of FeO@Ag nanoparticles as a highly effective nano-radiosensitizer for the treatment of glioblastoma cells.

Using CuO nanoparticles and hyperthermia in radiotherapy of MCF-7 cell line: synergistic effect in cancer therapy

“…As one of the most widespread types of cancer in female is breast cancer, it is presently cured with various therapies including surgery, radiotherapy, chemotherapy and hormone treatment [1]. A major tumour therapy is radiotherapy that applies ionizing radiation to eradicate cancerous cells [2]. However, the tumour should be delivered with a high radiation dose, which cannot be increased practically in some cases owing to the presence of some functional and healthy tissues hindering the efficacy of this treatment [3].…”

Fe 3 O 4 /Ag nanocomposite biosynthesised using Spirulina platensis extract and its enhanced anticancer efficiency

“…Their findings showed the significant application of Fe 3 O 4 @Ag nanoparticles as a mostly promising nano‐radiosensitiser for the treatment of glioblastoma cells [28]. Recently, no study has yet investigated the use of Fe 3 O 4 /Ag nanocomposite on the level of caspase protein in breast cancer MCF‐7 cells, so, here, caspase 3 assay used to determine the caspase 3 level after treatment by IC 50 concentrations of Fe 3 O 4 /Ag nanocomposite.…”

The Rational Design and Biological Mechanisms of Nanoradiosensitizers

“…The inhibition of autophagy by 3-MA alleviated cytotoxicity, indicating that autophagy plays key roles in radiosensitization effects [177]. Fe 3 O 4 @Ag NPs (11 nm) also exhibited radiosensitization effects in U251 cells through the inhibition of protective autophagy and the eventually increase in calcium-dependent apoptosis [178]. Gadolinium oxide NPs (2-5 nm) sensitized NSCLC cells (A549, NH1299, and NH1650) to radiation and induced cytostatic autophagy [125].…”