Radiosensitive core/satellite ternary heteronanostructure for multimodal imaging-guided synergistic cancer radiotherapy

Liu, Hongxing; Lin, Weiqiang; He, Lizhen; Chen, Tianfeng

doi:10.1016/j.biomaterials.2019.119545

Cited by 61 publications

(38 citation statements)

References 73 publications

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“…In order to enhance the efficiency of radiotherapy, materials containing a high atomic number (high-Z) element were usually considered as RSs since they can release a large amount of energy in their immediate vicinity through the Auger effect and photoelectric effect when receiving radiation. [4][5][6] The released large amount of energy was proposed to cause overproduction of reactive oxygen species (ROS) to break the DNA strand and nally induce cell death. 7 Until now, platinum analogues especially cisplatin are the most commonly used agents as RSs and have been proved to target DNA.…”

Section: Introductionmentioning

confidence: 99%

A highly X-ray sensitive iridium prodrug for visualized tumor radiochemotherapy

Zhao

Gao

et al. 2020

Chem. Sci.

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Section: Introductionmentioning

confidence: 99%

A highly X-ray sensitive iridium prodrug for visualized tumor radiochemotherapy

Zhao

Gao

et al. 2020

Chem. Sci.

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“…This part of experimental methods refer to the previous published articles [ [51] , [52] , [53] ].1 μmol EDC and 1 μmol NHS were added to the solution of ICG-COOH (10 mM, 200 μL) to activate the eCOOH, and the mixture was thoroughly incorporated. MIL101-NH 2 (10 mg/mL, 1 mL) was then added.…”

Section: Methodsmentioning

confidence: 99%

Reversing cold tumors to hot: An immunoadjuvant-functionalized metal-organic framework for multimodal imaging-guided synergistic photo-immunotherapy

Fan

Liu

Xue

et al. 2021

Bioactive Materials

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Immunotherapy assays using immunoadjuvants and tumor antigens could greatly increase the survival rates of patients with malignant tumors. As effective carriers, metal-organic frameworks (MOFs) have been widely utilized in cancer therapy due to their remarkable histocompatibility and low toxicity. Herein, we constructed a multimodal imaging-guided synergistic cancer photoimmunotherapy by employing a specific MOF (MIL101-NH 2 ) as the core carrier; the MOF was dual-dressed with photoacoustic and fluorescent signal donors (indocyanine green, ICG) and immune adjuvants (cytosine-phosphate-guanine sequence, CpG) and named ICG-CpG@MOF. This nanocarrier could passively target the tumor site through the EPR effect and achieve multimodal imaging (fluorescence, photoacoustic, photothermal and magnetic resonance imaging) of the tumor. Synergistic cancer photoimmunotherapy was achieved via simultaneous photodynamic and photothermal methods with 808 nm laser irradiation. ICG-CpG@MOF achieved the GSH-controlled release of immunoadjuvant into the tumor microenvironment. Furthermore, the released tumor-associated antigen along with CpG could induce the transformation of tumor cells from cold to hot by activating the immune system, which significantly enhanced tumor cytotoxicity and achieved high cure rates with minimal side-effects. This strategy utilizing multimodal imaging and synergistic cancer photoimmunotherapy provides a promising approach for the diagnosis and treatment of cancer.

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“…Advances in nanotechnology have facilitated the development of delivery systems to treat prostate-related disorders. Advantages of nanocarrier preparations include the combination of a variety of drugs, including biomacromolecule drugs; reduced degradation of unstable drugs for slow and controlled release; and increased residence time of relevant drugs to avoid frequent injections and meet the needs of prostatitis treatment ( Thakur and Agrawal, 2015 ; Liu et al, 2020 ; Liu et al, 2020 ; Wang et al, 2020 ; Lin et al, 2021 ; Liu et al, 2021 ). More importantly, the modular design and preparation characteristics of nanotechnology endow nanomaterials with intelligent characteristics ( van der Meel et al, 2019 ).…”

Section: Application Of Functionalized Nanomaterials In Prostatitismentioning

confidence: 99%

Therapeutic Applications of Functional Nanomaterials for Prostatitis

Liu

Chen

et al. 2021

Front. Pharmacol.

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Prostatitis is a common disease in adult males, with characteristics of a poor treatment response and easy recurrence, which seriously affects the patient’s quality of life. The prostate is located deep in the pelvic cavity, and thus a traditional infusion or other treatment methods are unable to easily act directly on the prostate, leading to poor therapeutic effects. Therefore, the development of new diagnostic and treatment strategies has become a research hotspot in the field of prostatitis treatment. In recent years, nanomaterials have been widely used in the diagnosis and treatment of various infectious diseases. Nanotechnology is a promising tool for 1) the accurate diagnosis of diseases; 2) improving the targeting of drug delivery systems; 3) intelligent, controlled drug release; and 4) multimode collaborative treatment, which is expected to be applied in the diagnosis and treatment of prostatitis. Nanotechnology is attracting attention in the diagnosis, prevention and treatment of prostatitis. However, as a new research area, systematic reviews on the application of nanomaterials in the diagnosis and treatment of prostatitis are still lacking. In this mini-review, we will highlight the treatment approaches for and challenges associated with prostatitis and describe the advantages of functional nanoparticles in improving treatment effectiveness and overcoming side effects.

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Radiosensitive core/satellite ternary heteronanostructure for multimodal imaging-guided synergistic cancer radiotherapy

Cited by 61 publications

References 73 publications

A highly X-ray sensitive iridium prodrug for visualized tumor radiochemotherapy

A highly X-ray sensitive iridium prodrug for visualized tumor radiochemotherapy

Reversing cold tumors to hot: An immunoadjuvant-functionalized metal-organic framework for multimodal imaging-guided synergistic photo-immunotherapy

Therapeutic Applications of Functional Nanomaterials for Prostatitis

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