Radioresistance of Serpinb3a−/− Mice and Derived Hematopoietic and Marrow Stromal Cell Lines

Thermozier, Stephanie; Zhang, Xichen; Hou, Wen Chi; Fisher, Renee; Epperly, Michael W.; Liu, Bing; Bahar, İvet; Wang, Hong; Greenberger, Joel S.

doi:10.1667/rr15379.1

Cited by 4 publications

(3 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…28,29 Investigations indicates that Serpinb3a−/− mice that is equal to SERPINB3 and SERPINB4 in humans has shown resistance in radiotherapy. 30,31 In addition, suppression of TP53 is also processed by the activation of TRIM21-SERPINB5 that consequently results in NPC radioresistance. 32 Finally, SERPIND1 (serpin family D member 1) was also found as an up-regulated protein in the serum of radioresistant patients of NPC.…”

Section: Discussionmentioning

confidence: 99%

Predicting Radioresistant Biomarkers in Nasopharyngeal Carcinoma Patients Via Protein-Protein Interaction Network Analysis

et al. 2021

View full text Add to dashboard Cite

Introduction: Radiotherapy as the first-line nasopharyngeal carcinoma (NPC) treatment provides different responses including radioresistant and radiosensitive states. In order to investigate the molecular basis of radioresistancy, protein-protein interaction network analysis of proteome data prior to therapy was performed. Methods: 20 dysregulated proteins of the patients who were radioresistant were extracted from the literature. Cytoscape and its plug-ins were used for the resistant network construction and its centrality analysis. Furthermore, ClueGO+ CluePedia application determined the most statistically significant biological processes (BP) related to the hubs. Results: Fourteen hubs were concluded and no differentially expressed protein (DEP) was among these agents. Among the hubs, albumin (ALB) and fibronectin (FN1) were the hub-bottlenecks, and the Serpin family was present. What is more, SERPIND1 was the highest degree-valued DEP in the network. Conclusion: It can be concluded that the central elements of the NPC network could be noteworthy for improving the radiotherapy outcome and overcoming its limitations. However, complementary studies are required for a better understanding of their major role.

show abstract

Section: Discussionmentioning

confidence: 99%

Predicting Radioresistant Biomarkers in Nasopharyngeal Carcinoma Patients Via Protein-Protein Interaction Network Analysis

et al. 2021

View full text Add to dashboard Cite

show abstract

“…There are multiple cell death pathways initiated by exposure of cell lines, tissues, and organs to TBI (1,20). Radiation mitigator drugs delivered 24 h after irradiation, which target each of three cell death pathways (apoptosis, necroptosis, and ferroptosis), have been demonstrated to be more effective in increasing survival after TBI than the delivery of one mitigator or administration of two mitigators (18).…”

Section: Discussionmentioning

confidence: 99%

“…The breeding genotyping of FA mice of each genotype, as well as normal control littermates from each breeding have been described previously (1)(2)(3). Serpinb3a −/− and Balb/c control littermates were bred and maintained according to published methods (20).…”

Section: Methodsmentioning

confidence: 99%

Fanconi Anemia Mouse Genotype-specific Mitigation of Total Body Irradiation by GS-Nitroxide JP4-039

Epperly

Fisher

Zhang

et al. 2019

In Vivo

Self Cite

View full text Add to dashboard Cite

Background/Aim: Radiation mitigator, GSnitroxide, JP4-039, was evaluated for mitigation of total body irradiation (TBI) in Fanconi anemia (FA) Fancd2 −/− (129/Sv), Fancg −/− (B6), and Fanca −/− (129/Sv) mice. Materials and Methods: JP4-039 dissolved in 30% 2hydroxypropyl-β-cyclodextrin was injected intramuscularly 24 h after total body irradiation (9.25 Gy) into Fanca −/− , Fancd2 −/− and Fancg −/− mice. Irradiation survival curves were performed in vitro using bone marrow stromal cell lines derived from Fanca −/− , Fancd2 −/− and Fancg −/− mice. Results: FA mice demonstrate genotype specific differences in TBI mitigation by JP4-039. Radiation effects in derived bone marrow stromal cell lines in vitro were mitigated by drugs that block apoptosis, but not necroptosis or ferroptosis. Conclusion: FA mouse models are valuable for elucidating DNA repair pathways in cell and tissue responses to TBI, and the role of drugs that target distinct cell death pathways.

show abstract

A Model Checking-based Analysis Framework for Systems Biology Models

Liu

Safa

2020

2020 57th ACM/IEEE Design Automation Conference (DAC)

View full text Add to dashboard Cite

Radioresistance of Serpinb3a−/− Mice and Derived Hematopoietic and Marrow Stromal Cell Lines

Cited by 4 publications

References 38 publications

Predicting Radioresistant Biomarkers in Nasopharyngeal Carcinoma Patients Via Protein-Protein Interaction Network Analysis

Predicting Radioresistant Biomarkers in Nasopharyngeal Carcinoma Patients Via Protein-Protein Interaction Network Analysis

Fanconi Anemia Mouse Genotype-specific Mitigation of Total Body Irradiation by GS-Nitroxide JP4-039

A Model Checking-based Analysis Framework for Systems Biology Models

Contact Info

Product

Resources

About