Radioprotectors in Radiotherapy

Nair, Cherupally Krishnan Krishnan; Parida, Dillip Kumar; Nomura, Taisei

doi:10.1269/jrr.42.21

Cited by 401 publications

(240 citation statements)

References 86 publications

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“…Radioprotective agents are those administered before exposure to ionizing radiation to reduce the damaging effects for normal cells, including radiation-induced lethality (Parihar et al 2007). Many synthetic as well as natural agents have the efficacy as a protector against radiation injuries (Nair et al 2001). Plant extracts such as Mentha (Samarth et al 2002) have been found to have radioprotective effects in mammals.…”

Section: Introductionmentioning

confidence: 99%

Mentha piperita as a pivotal neuro-protective agent against gamma irradiation induced DNA fragmentation and apoptosis

2012

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Section: Introductionmentioning

confidence: 99%

Mentha piperita as a pivotal neuro-protective agent against gamma irradiation induced DNA fragmentation and apoptosis

2012

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“…Radiotherapy generates copious amounts of hydroxyl free radicals through the action of radiation on water which makes up around 80% of human tissues. [16] Many antioxidants have been shown to limit the toxicity of radiotherapy in animal models. [17] Here, Patil and colleagues investigated the radioprotective effect of two antioxidants, RUT and QRT, in mice.…”

Section: Spotlight On Original Articlesantioxidants Protect Against Dmentioning

confidence: 99%

Mysteries of the mighty microbiota

Walton¹

2014

Biomed J

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In this issue of the Biomedical Journal, we take a close look at the microbial metropolis of the gut and examine its impact on human health. We also highlight an interesting animal study showing that short-term treatment with antioxidants can protect tissues against the genotoxic effects of ionizing radiation. Such reports continue to fuel the hotly debated topic of the benefits of antioxidants. This issue also features several clinical studies examining the efficacy of current treatment regimens for primary breast lymphoma, Helicobacter pylori, and multidrug-resistant Acinetobacter baumannii. (Biomed J 2014;37:241-244)

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“…Sulfhydryl bond in the structure of l ‐cysteine ( l ‐Cys) allows it to act as a radio protector by scavenging free radicals 22, 23, 24. Experiments in rats demonstrated that animals administered l ‐Cys withstood normally lethal doses of X‐rays25 and showed considerably reduced damage to essential organs compared to untreated animals 26.…”

Section: Introductionmentioning

confidence: 99%

Radiation‐Sensitive Dendrimer‐Based Drug Delivery System

Chou

Yuh

et al. 2017

Advanced Science

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Combination of chemotherapy and radiotherapy is used to enhance local drug delivery while reducing off‐target tissue effects. Anticancer drug doxorubicin (DOX) is loaded into l‐cysteine modified G4.5 dendrimer (GC/DOX) and released at different pH values in the presence and absence of γ‐radiation. Presence of γ‐radiation significantly improves DOX release from the GC/DOX under acidic pH conditions, suggesting that GC dendrimer is a radiation‐sensitive drug delivery system. GC/DOX is further evaluated by determining cytotoxicity in uterine cervical carcinoma HeLa cells. GC/DOX shows high affinity for cancer cells and effective drug release following an external stimulus (radiation exposure), whereas an in vivo zebrafish study confirms that l‐cysteine acts as a radiosensitizer. GC/DOX treatment combined with radiotherapy synergistically and successfully inhibits cancer cell growth.

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Radioprotectors in Radiotherapy

Cited by 401 publications

References 86 publications

Mentha piperita as a pivotal neuro-protective agent against gamma irradiation induced DNA fragmentation and apoptosis

Mentha piperita as a pivotal neuro-protective agent against gamma irradiation induced DNA fragmentation and apoptosis

Mysteries of the mighty microbiota

Radiation‐Sensitive Dendrimer‐Based Drug Delivery System

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