Radioprotective property of an aqueous extract from valeriana wallichii

Katoch, Omika; Kaushik, Saroj; Kumar, M.S. Yogendra; Agrawala, Paban K.; Misra, Kshipra

doi:10.4103/0975-7406.103272

Cited by 19 publications

(2 citation statements)

References 15 publications

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“…43 The literature review reveals that quercetin, apigenin, hesperidin, and rutin can significantly enhance lymphocyte proliferation and secretion of key immune system cytokines and remarkably reduce the damage to peripheral blood lymphocytes. [55][56][57][58] It has been demonstrated that administrating resveratrol to workers who work in an environment with a high potential for electromagnetic hazards can help to reconstruct the expression and function of the nuclear factor-kappa B (NFkappa B), IL-6, and ultimately prevent the deterioration of the immune system. 59…”

Section: Protective Effects On the Immune Systemmentioning

confidence: 99%

An Overview of the Cellular Mechanisms of Flavonoids Radioprotective Effects

Saberi

2019

Adv Pharm Bull

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Considering the remarkable application of radiotherapy in the treatment and diagnosis of various diseases and even nuclear war, it is important to protect healthy tissues and people at risk from the radiation. Currently, there is no ideal and safe radioprotective agent available and we are seeing a great effort to find these agents from natural sources. Phenolic compounds, as well as flavonoid, are presented widely as the second metabolite in plants and they have been considered for investigation according to their benefits for human health, healing and preventing many disorders. The major bioactive benefits of flavonoids include antioxidant, anti-inflammatory, anti-tumor, anti-aging, anti-bacterial and viral, neuroprotection and radioprotective effects. Their lower toxicity and oral administration have made it suitable for radiotherapy patient, radiation, military forces, and even the general public. This review attempts to provide a summary of the main molecular mechanisms involved in flavonoid radio-protective effects. Data of these studies will provide a comprehensive perspective to flavonoids and can help to optimize their effects in radioprotection procedures.

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Section: Protective Effects On the Immune Systemmentioning

confidence: 99%

An Overview of the Cellular Mechanisms of Flavonoids Radioprotective Effects

Saberi

2019

Adv Pharm Bull

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“…From the rhizomes, some important compounds, such as citric acid, malic acid, maliol, succinic acid and tartaric acid have been isolated [ 220 , 221 ]. The root extract of V. wallichii was found to significantly protect against radiation-induced free radicals at 4 h after 5 Gy irradiation, reduced prolonged oxidative stress led increase in mitochondrial mass, enhanced reproductive viability of cultured cells and protected against radiation-induced DNA damage [ 222 ].…”

Section: Radioprotection By Medicinal Aromatic Plantsmentioning

confidence: 99%

Medicinally Important Aromatic Plants With Radioprotective Activity

Samarth

Matsumoto

2017

Future Sci. OA

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Aromatic plants are often used as natural medicines because of their remedial and inherent pharmacological properties. Looking into natural resources, particularly products of plant origin, has become an exciting area of research in drug discovery and development. Aromatic plants are mainly exploited for essential oil extraction for applications in industries, for example, in cosmetics, flavoring and fragrance, spices, pesticides, repellents and herbal beverages. Although several medicinal plants have been studied to treat various conventional ailments only a handful studies are available on aromatic plants, especially for radioprotection. Many plant extracts have been reported to contain antioxidants that scavenge free radicals produced due to radiation exposure, thus imparting radioprotective efficacy. The present review focuses on a subset of medicinally important aromatic plants with radioprotective activity.

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Valeriana jatamansi: An herbaceous plant with multiple medicinal uses

Jugran

Rawat

Bhatt

et al. 2019

Phytotherapy Research

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Valeriana jatamansi Jones (Family: Caprifoliaceae), a high value medicinal plant, was distributed in many countries of Asia. The species possesses important valepotriates and is a good source of flavones or flavone glycosides, lignans, sesquiterpenoids or sesquiterpenoid glycoside, bakkenolide type sesquiterpenoids, phenolic compounds, terpinoids, etc. The use of the species in traditional and modern medicines is well known. For instance, V. jatamansi is very important for its insect repelling and antihelmethic properties. Similarly, sedative, neurotoxic, cytotoxic, antidepressant, antioxidant, and antimicrobial activities of the species in various ailments in the indigenous system of medicine, particularly in Asia, are reported. This review focuses on the detailed phytochemical composition, medicinal uses, and pharmacological properties of V. jatamansi along with analysis of botanical errors in published literature and reproducibility of the biomedical researches on this multipurpose herbaceous species.

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Radioprotective property of an aqueous extract from valeriana wallichii

Cited by 19 publications

References 15 publications

An Overview of the Cellular Mechanisms of Flavonoids Radioprotective Effects

An Overview of the Cellular Mechanisms of Flavonoids Radioprotective Effects

Medicinally Important Aromatic Plants With Radioprotective Activity

Valeriana jatamansi: An herbaceous plant with multiple medicinal uses

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