Radioprotective Efficiency of Recombinant Flagellin and Interleukin-1 Beta with Combined Administration

Murzina, Elena V.; Sofronov, G. A.; Симбирцев, А. С.; Ishchenko, A. M.; Antipova, T. O.; Aksenova, Natalia V.; Veselova, Olga M.; Zatsepin, Victor

doi:10.1007/s11094-019-1910-1

Cited by 2 publications

(1 citation statement)

References 10 publications

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“…Some of the agents which have been combined with amifostine or its derivatives to improve efficacy are G-CSF, metformin, selenium, vitamin-E, gamma-tocotrienol, prostaglandin E2, β-glucan, and roncho-Vaxom [199]. Similarly, there are reports for the combination of flagellin and IL-1β [200], gamma-tocotrienol and Simvastatin/pentoxifylline [201,202], filgrastim and α-tocopherol succinate [203], and PEGfilgrastim and Romiplostim [73].…”

Section: Poly-pharmacy and Repurposing Approachesmentioning

confidence: 99%

Pharmacological management of ionizing radiation injuries: current and prospective agents and targeted organ systems

Singh

Seed²

2020

Expert Opinion on Pharmacotherapy

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Introduction: There is a limited array of currently available medicinals that are useful for either the prevention, mitigation or treatment of bodily injuries arising from ionizing radiation exposure. Area covered: In this brief article, the authors review those pharmacologic agents that either are currently being used to counter the injurious effects of radiation exposure, or those that show promise and are currently under development. Expert opinion: Although significant, but limited progress has been made in the development and fielding of safe and effective pharmacotherapeutics for select types of acute radiation-associated injuries, additional effort is needed to broaden the scope of drug development so that overall health risks associated with both short-and long-term injuries in various organ systems can be reduced and effectively managed. There are several promising radiation countermeasures that may gain regulatory approval from the government in the near future for use in clinical settings and in the aftermath of nuclear/radiological exposure contingencies. ARTICLE HISTORY

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Section: Poly-pharmacy and Repurposing Approachesmentioning

confidence: 99%

Pharmacological management of ionizing radiation injuries: current and prospective agents and targeted organ systems

Singh

Seed²

2020

Expert Opinion on Pharmacotherapy

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History of the research laboratory (medicinal and environmental toxicology) of the Military medical academy named after S.M. Kirov

Sofronov

Murzina

Denisov

et al. 2021

Bulletin of the Russian Military Medical Academy

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This paper presents the history of the formation of the Research Department of the Experimental Medicine of the Research Center of the Military Medical Academy named after S.M. Kirov. The department is the only division of the academy that conducts experiments on animal models and field tests using laboratory animals in the interests of the Armed Forces of the Russian Federation. The paper also presents the main scientific achievements and development prospects of one of the three laboratories of the department Research Laboratory of Medicinal and Environmental Toxicology. In the direction of drug toxicology, the laboratory staff worked for 15 years in cooperation with the Scientific Center of the Russian Academy of Sciences (Pushchino) on the problems of perfluorocarbon-based blood substitutes. The results of the study helped deepen the understanding of the mechanisms of the physiological activity of perfluorocarbon emulsions and the expansion of the areas of clinical application of perftoran. The ecotoxicological direction of scientific research is represented by two large-scale cycles of scientific studies. The first was devoted to the medical support of oil refining to increase the protection of personnel who have been professionally exposed to toxic chemicals from the damage caused by chemical accidents. The second area of environmental research, which has been significantly updated in recent years, is devoted to the study of remote environmental and biomedical consequences of the use of chemical weapons by the US Army in the period from 1966 to 1972 in Vietnam. In recent years, the laboratory has focused on problems related to the search and development of new radiation countermeasure agents including biotechnological products and their compositions. Studies are also being conducted to improve the complex therapy of patients with sepsis, in which methods of extracorporeal blood purification are used in the treatment. These works are relevant for military and civilian health care and are performed in cooperation with the departments of the academy and several leading research organizations in St. Petersburg.

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Radioprotective Efficiency of Recombinant Flagellin and Interleukin-1 Beta with Combined Administration

Cited by 2 publications

References 10 publications

Pharmacological management of ionizing radiation injuries: current and prospective agents and targeted organ systems

Pharmacological management of ionizing radiation injuries: current and prospective agents and targeted organ systems

History of the research laboratory (medicinal and environmental toxicology) of the Military medical academy named after S.M. Kirov

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