Radioprotective Effects of Nigella Sativa Oil Against Oxidative Stress in Liver Tissue of Rats Exposed to Total Head Irradiation

Abstract

NSO reduces oxidative stress markers and has antioxidant effects, which also augments the antioxidant capacity in the liver tissue of rats.

Radioprotective effect of thymoquinone on salivary gland of rats exposed to total cranial irradiation

“…However, it is not always possible to keep the normal tissues outside of the treatment field and to avoid side effects and complications of the irradiation. Exposure to high amounts of ionizing radiation results in damage to the hematopoietic, gastrointestinal, and central nervous systems, depending on the radiation dose . It is important to protect normal tissues in the treatment field.…”

“…Exposure to high amounts of ionizing radiation results in damage to the hematopoietic, gastrointestinal, and central nervous systems, depending on the radiation dose. 6,26,27 It is important to protect normal tissues in the treatment field. The nature and degree of such side effects depends on the dose of radiation and the sensitivity of the organs irradiated.…”

“…Efforts to decrease toxicity of irradiation to normal tissue, organs, and cells have led into searching for cytoprotective agents. Unfortunately, most of the radioprotectors possess toxic side effects, which limit its role in medical treatment …”

“…Unfortunately, most of the radioprotectors possess toxic side effects, which limit its role in medical treatment. 6,7 All cells in the body are exposed chronically to oxidants from both endogenous and exogenous sources. To control the flux of ROS and RNS, aerobic cells have developed their own defense system against free radical attacks, the antioxidant system, which includes enzymatic and nonenzymatic components.…”

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“…The liver tissue total oxidant status, lipid hydroperoxide level, and oxidative stress index were increased in the irradiated rats compared to the control rats, while total antioxidant status and sulfhydryl (-SH) levels were significantly declined. Treatment with NSO reduced oxidative stress markers, also enhanced the antioxidant capacity in the liver tissue of irradiated rats 53 . Also, NSO has been revealed to prevent oxidative injury during cerebral ischemiareperfusion injury in rat 54 .…”