Radioprotective effect of sesamol on γ-radiation induced DNA damage, lipid peroxidation and antioxidants levels in cultured human lymphocytes

Prasad, Nagarajan Rajendra; Menon, Venugopal P.; Vasudev, V.; Pugalendi, Kodukkur Viswanathan

doi:10.1016/j.tox.2004.12.009

Cited by 136 publications

(79 citation statements)

References 47 publications

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“…These ROS interact with living cell components producing harmful free radicals leading to lipid peroxidation and DNA damage processes (Jagetia & Reddy, 2005). ROS can also interrupt the balance of endogenous protective systems, including enzymic antioxidants (CAT and GSHPx) defense system (Prasad, Menon, Vasudev, & Pugalendi, 2005). The increase in the oxidant biomarkers in the present work has been reported before (Yurut-Caloglu et al, 2015).…”

Section: Discussionsupporting

confidence: 52%

Gamma-aminobutyric acid ameliorates gamma rays-induced oxidative stress in the small intestine of rats

El-Hady¹,

Gewefel²,

Badawi³

et al. 2017

JoBAZ

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Background: The current study aimed to evaluate the role of gamma-amino butyric acid (GABA) in modulating histopathological and biochemical disturbances in the rat's small intestine following gamma radiation exposure. Results:The results showed that whole body gamma irradiation (6 Gy) of rats induced mucosal damage, hemorrhage, increased cellularity of the lamina propria layer with areas of complete ulcerations. Histopathological changes were associated with a significant increase in malondialdehyde (MDA) and advanced oxidation protein products (AOPPs). In parallel, a significant decrease in catalase (CAT) and glutathione peroxidase (GSH-Px) activities was demonstrated. Administration of GABA (200 mg/kg body weight GABA daily via gastric gavage for three consecutive weeks) after irradiation of rats has significantly improved the oxidant/antioxidant status which was associated with regeneration of the small intestinal cell structure. Conclusion: Gastric administration of GABA was found to offer an advantageous treatment against gamma irradiation-induced small intestine oxidative stress in rats, probably by utilizing ameliorative effects via its antioxidant and free radical-scavenging activities. Its mechanisms need to be further investigated.

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Section: Discussionsupporting

confidence: 52%

Gamma-aminobutyric acid ameliorates gamma rays-induced oxidative stress in the small intestine of rats

El-Hady¹,

Gewefel²,

Badawi³

et al. 2017

JoBAZ

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“…The decrease in the activities of SOD, CAT and GST, and the decreased level of GSH in the brain tissues may be due to their utilization by the enhanced production of ROS. 38) In agreement with this finding, Bhatia and Jain 39) observed a significant depletion in the antioxidant system, and an increased lipid peroxides in animals exposed to whole body g-irradiation. The decreased levels of GSH in brain of irradiated animals may have resulted from the activity of GST and glutathione peroxidase (GPx) in reducing lipid hydroperoxide to stable non-radical lipid alcohols or GSH is directly utilized as an antioxidant in terminating free radical reaction initiated by irradiation.…”

Section: )mentioning

confidence: 55%

Protective Effect of Kolaviron, a Biflavonoid from Garcinia kola Seeds, in Brain of Wistar Albino Rats Exposed to Gamma-Radiation

Adaramoye

2010

Biological & Pharmaceutical Bulletin

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This study was designed to evaluate the protective effect of kolaviron (KV), a biflavonoid from Garcinia kola seeds, against g g-radiation (5 Gy)-induced oxidative stress in brain of Wistar rats. Vitamin C (VC) served as standard antioxidant. Forty-four rats were divided into 4 groups of 11 animals each. One group was un-irradiated (normal), two groups were treated with KV and VC (250 mg/kg) for 6 weeks prior to and 8 weeks after irradiation, and fourth group was only irradiated. Rats were sacrificed 1 and 8 weeks after irradiation. Cellular alterations were monitored using changes in the levels of malondialdehyde (MDA)-an index of lipid peroxidation, superoxide dismutase (SOD), glutathione-S-transferase (GST), reduced glutathione (GSH), catalase (CAT), alanine and aspartate aminotransferases (ALT and AST), urea and creatinine. MDA levels increased significantly (pϽ Ͻ0.05) by 90% and 151% after 1 and 8 weeks of irradiation. Furthermore, levels of GSH and antioxidant enzymes were significantly (pϽ Ͻ0.05) decreased in g g-irradiated animals. GSH and GST decreased by 61% and 43% after 1 week, and by 75% and 74%, after 8 weeks of exposure, respectively. g g-Irradiation decreased SOD and CAT levels by 53% and 68%, respectively, and caused significant ( pϽ Ͻ0.05) increases in serum ALT, AST and urea after 8 weeks of exposure. Treatment with KV and VC significantly decreased the levels of MDA, ALT, AST and urea. The antioxidant indices were significantly ameliorated in KV-treated animals. These data suggest that kolaviron may protect against g g-radiation-induced oxidative stress in brain of exposed rats.

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“…These ROS, generated by radiolysis of water, can interact with biological macromolecules producing various toxic secondary free radicals and reactive nitrogen species (RNS), which could result in further alteration of DNA, proteins, and lipids, leading to cellular damage (Jagetia and Reddy, 2005). Lipid peroxidation by IR-induced ROS can have harmful effects on biological membranes (Prasad et al, 2005). In addition, because endogenous protective and enzymatic antioxidant defense systems are insufficient for scavenging of IR-induced free radicals, ROS can also cause the unbalance of intracellular redox status (Prasad et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

“…Lipid peroxidation by IR-induced ROS can have harmful effects on biological membranes (Prasad et al, 2005). In addition, because endogenous protective and enzymatic antioxidant defense systems are insufficient for scavenging of IR-induced free radicals, ROS can also cause the unbalance of intracellular redox status (Prasad et al, 2005). The presence of antioxidants is capable to delay or inhibit oxidation processes and thus to provide protection against radiation through reduction of free radicals (Torres et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Phenylpropanoids in radioregulation: double edged sword

2011

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Radiotherapy, frequently used for treatment of solid tumors, carries two main obstacles including acquired radioresistance in cancer cells during radiotherapy and normal tissue injury. Phenylpropanoids, which are naturally occurring phytochemicals found in plants, have been identified as potential radiotherapeutic agents due to their anti-cancer activity and relatively safe levels of cytotoxicity. Various studies have proposed that these compounds could not only sensitize cancer cells to radiation resulting in inhibition of growth and cell death but also protect normal cells against radiation-induced damage. This review is intended to provide an overview of recent investigations on the usage of phenylpropanoids in combination with radiotherapy in cancer treatment.

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Radioprotective effect of sesamol on γ-radiation induced DNA damage, lipid peroxidation and antioxidants levels in cultured human lymphocytes

Cited by 136 publications

References 47 publications

Gamma-aminobutyric acid ameliorates gamma rays-induced oxidative stress in the small intestine of rats

Gamma-aminobutyric acid ameliorates gamma rays-induced oxidative stress in the small intestine of rats

Protective Effect of Kolaviron, a Biflavonoid from Garcinia kola Seeds, in Brain of Wistar Albino Rats Exposed to Gamma-Radiation

Phenylpropanoids in radioregulation: double edged sword

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