Radioprotective effect of diethylcarbamazine on radiation-induced acute lung injury and oxidative stress in mice

Farzipour, Soghra; Amiri, Fereshteh Talebpour; Mihandoust, Ehsan; Shaki, Fatemeh; Noaparast, Zohreh; Ghasemi, Arash; Hosseinimehr, Seyed Jalal

doi:10.1007/s10863-019-09820-9

Cited by 14 publications

(7 citation statements)

References 44 publications

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“…It is reported that the generation of MDA can aggravate the damage of the cell membrane and also reflect antioxidant capacity 38,39 . Change in inflammatory cytokines may be a downstream process of increased MDA production in the normal tissues of the CONV group.…”

Section: Discussionmentioning

confidence: 97%

“…It is reported that the generation of MDA can aggravate the damage of the cell membrane and also reflect antioxidant capacity. 38,39 Change in inflammatory cytokines may be a downstream process of increased MDA production in the normal tissues of the CONV group. Increased MDA may facilitate cell membrane attack, and immune cells, such as macrophages and monocytes, would respond by secreting various inflammatory cytokines.…”

Section: Discussionmentioning

confidence: 99%

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Radioprotective effect of X‐ray abdominal FLASH irradiation: Adaptation to oxidative damage and inflammatory response may be benefiting factors

et al. 2022

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Background Ultrahigh dose‐rate irradiation (FLASH‐IR) was reported to be efficient in tumor control while reducing normal tissue radiotoxicity. However, the mechanism of such phenomenon is still unclear. Besides, the FLASH experiments using high energy X‐ray, the most common modality in clinical radiotherapy, are rarely reported. This study aims to investigate the radiobiological response using 6 MV X‐ray FLASH‐IR or conventional dose‐rate IR (CONV‐IR). Methods The superconducting linac of Chengdu THz Free Electron Laser (CTFEL) facility was used for FLASH‐IR, a diamond radiation detector and a CeBr3 scintillation detector were used to monitor the time structure and dose rate of FLASH pulses. BALB/c nude mice received whole abdominal 6 MV X‐ray FLASH‐IR or CONV‐IR, the prescribed dose was 15 Gy or 10 Gy and the delivered absolute dose was monitored with EBT3 films. The mice were either euthanized 24 h post‐IR to evaluate acute tissue responses or followed up for 6 weeks to observe late‐stage responses and survival probability. Complete blood count, histological analyses, and measurement of cytokine expression and redox status were performed. Results The mean dose rate of >150 Gy/s and instantaneous dose rate of >5.5 × 105 Gy/s was reached in FLASH‐IR at the center of mice body. After 6 weeks’ follow‐up of mice that received 15 Gy IR, the FLASH group showed faster body weight recovery and higher survival probability than the CONV group. Histological analysis showed that FLASH‐IR induced less acute intestinal damage than CONV‐IR. Complete blood count and cytokine concentration measurement found that the inflammatory blood cell counts and pro‐inflammatory cytokine concentrations were elevated at the acute stage after both FLASH‐IR and CONV‐IR. However, FLASH irradiated mice had significantly fewer inflammatory blood cells and diminished pro‐inflammatory cytokine at the late stage. Moreover, higher reactive oxygen species (ROS) signal intensities but significantly reduced lipid peroxidation were found in the FLASH group than in the CONV group in the acute stage. Conclusions The radioprotective effect of 6 MV X‐ray FLASH‐IR was observed. The differences in inflammatory responses and redox status between the two groups may be the factors responsible for reduced radiotoxicities following FLASH‐IR. Further studies are required to thoroughly evaluate the impact of ROS on FLASH effect.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Radioprotective effect of X‐ray abdominal FLASH irradiation: Adaptation to oxidative damage and inflammatory response may be benefiting factors

et al. 2022

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“…Acute lung injury, a primary cause of trauma hemorrhagic shock (THS), could develop into acute respiratory distress syndrome (ARDS) [ 1 , 2 ]. Acute lung injury can also cause dyspnea, endothelium damage, and gas exchange deterioration [ 3 , 4 ]. Previous studies have reported that severe THS may result in inflammatory response in multiple organ and high mortality [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Role and Mechanism of Maresin-1 in Acute Lung Injury Induced by Trauma-Hemorrhagic Shock

et al. 2020

Med Sci Monit

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“…69 Surfaxin, a synthetic peptide-containing surfactant used to treat respiratory distress syndrome, and diethylcarbamazine citrate, used to treat filariasis, have been investigated to treat IR-induced lung injury. 70,71 The initial indication for ciprofloxacin was the treatment of gram-negative bacterial infection, although it has been used to treat combined IR injury. 72 Captopril, perindopril, ramipril, and other angiotensin-converting enzyme inhibitors have been evaluated as radiomitigators in various IR-related injuries, including those involving damage to the lungs and skin.…”

Section: The Mechanism Of Ir-induced Injurymentioning

confidence: 99%

Development of radiation countermeasure agents for acute radiation syndromes

Guan,

Li,

Meng

2023

Anim Models and Exp Med

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The risk of internal and external exposure to ionizing radiation (IR) has increased alongside the development and implementation of nuclear technology. Therefore, serious security issues have emerged globally, and there has been an increase in the number of studies focusing on radiological prevention and medical countermeasures. Radioprotective drugs are particularly important components of emergency medical preparedness strategies for the clinical management of IR‐induced injuries. However, a few drugs have been approved to date to treat such injuries, and the related mechanisms are not entirely understood. Thus, the aim of the present review was to provide a brief overview of the World Health Organization's updated list of essential medicines for 2023 for the proper management of national stockpiles and the treatment of radiological emergencies. This review also discusses the types of radiation‐induced health injuries and the related mechanisms, as well as the development of various radioprotective agents, including Chinese herbal medicines, for which significant survival benefits have been demonstrated in animal models of acute radiation syndrome.

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Radioprotective effect of diethylcarbamazine on radiation-induced acute lung injury and oxidative stress in mice

Cited by 14 publications

References 44 publications

Radioprotective effect of X‐ray abdominal FLASH irradiation: Adaptation to oxidative damage and inflammatory response may be benefiting factors

Radioprotective effect of X‐ray abdominal FLASH irradiation: Adaptation to oxidative damage and inflammatory response may be benefiting factors

Role and Mechanism of Maresin-1 in Acute Lung Injury Induced by Trauma-Hemorrhagic Shock

Development of radiation countermeasure agents for acute radiation syndromes

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