Radioprotection by caffeine pre- and post-treatment in the bone marrow chromosomes of mice given whole-body γ-irradiation

Farooqi, Zeba; Kesavan, P.C.

doi:10.1016/0027-5107(92)90203-e

Cited by 30 publications

(15 citation statements)

References 28 publications

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“…Finally, other beneficial effects elicited by caffeine in the context of cancer treatments may occur by modulation of their toxic side effects. In fact, chronic pretreatment with caffeine was reported to produce a significant degree of radioprotection (Farooqi and Kesavan 1992), and topical or intratumoral application was shown to decrease toxic side-effects in animal models, without changes in efficacy (Hebbar et al 2002). These studies reinforce the evidences that methylxanthines do in fact display a meaningful pharmacological potential to be used either directly used or as co-adjuvants in cancer treatments.…”

Section: Cancersupporting

confidence: 52%

Pharmacological potential of methylxanthines: Retrospective analysis and future expectations

Monteiro

Alves

Oliveira

et al. 2018

Critical Reviews in Food Science and Nutrition

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Methylated xanthines (methylxanthines) are available from a significant number of different botanical species. They are ordinarily included in daily diet, in many extremely common beverages and foods. Caffeine, theophylline and theobromine are the main methylxanthines available from natural sources. The supposedly relatively low toxicity of methylxanthines, combined with the many beneficial effects that have been attributed to these compounds through time, generated a justified attention and a very prolific ground for dedicated scientific reports. Methylxanthines have been widely used as therapeutical tools, in an intriguing range of medicinal scopes. In fact, methylxanthines have been/were medically used as Central Nervous System stimulants, bronchodilators, coronary dilators, diuretics and anti-cancer adjuvant treatments. Other than these applications, methylxanthines have also been hinted to hold other beneficial health effects, namely regarding neurodegenerative diseases, cardioprotection, diabetes and fertility. However, it seems now consensual that toxicity concerns related to methylxanthine consumption and/or therapeutic use should not be dismissed. Taking all the knowledge and expectations on the potential of methylxanthines into account, we propose a systematic look at the past and future of methylxanthine pharmacologic applications, discussing all the promise and anticipating possible constraints. Anyways, methylxanthines will still substantiate considerable meaningful research and discussion for years to come.

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Section: Cancersupporting

confidence: 52%

Pharmacological potential of methylxanthines: Retrospective analysis and future expectations

Monteiro

Alves

Oliveira

et al. 2018

Critical Reviews in Food Science and Nutrition

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“…The radioprotective property of caffeine was evaluated in mice with acute and chronic dosing as well as caffeine treatment given before or after irradiation. 52 It has been reported that acute doses of caffeine before or after irradiation were responsible for a reduction in the number of chromosomal aberrations. The different doses of caffeine were also studied for cytogenetic biomarkers in Chinese hamster V79 cells.…”

Section: Modulation Of Radiation-induced Cytogenetic Damage By Varioumentioning

confidence: 99%

Utilization of cytogenetic biomarkers as a tool for assessment of radiation injury and evaluation of radiomodulatory effects of various medicinal plants – a review

Samarth¹,

Samarth²,

Matsumoto³

2015

DDDT

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Systematic biological measurement of “cytogenetic endpoints” has helped phenomenally in assessment of risks associated with radiation exposure. There has been a surge in recent times for the usage of radioactive materials in health care, agriculture, industrial, and nuclear power sectors. The likelihood of radiation exposure from accidental or occupational means is always higher in an overburdened ecosystem that is continuously challenged to meet the population demands. Risks associated with radiation exposure in this era of modern industrial growth are minimal as international regulations for maintaining the safety standards are stringent and strictly adhered to, however, a recent disaster like “Fukushima” impels us to think beyond. The major objective of radiobiology is the development of an orally effective radio-modifier that provides protection from radiation exposure. Once available for mass usage, these compounds will not only be useful for providing selective protection against accidental and occupational radiation exposure but also help to permit use of higher doses of radiation during treatment of various malignancies curtailing unwarranted adverse effects imposed on normal tissues. Bio-active compounds isolated from natural sources enriched with antioxidants possess unique immune-modulating properties, thus providing a double edged benefit over synthetic radioprotectors. We aim to provide here a comprehensive overview of the various agents originating from plant sources that portrayed promising radioprotection in various experimental models with special emphasis on studies that used cytogenetic biomarkers. The agents will include crude extracts of various medicinal plants, purified fractions, and herbal preparations.

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“…or in drinking water, reduced radiationinduced frequency of chromosomal aberrations. Farooqi and Kesavan, had shown that administration immediately after radiation exposure also significantly reduced chromosome aberrations (Farooqi and Kesavan 1992). In our other study, George et al showed that when caffeine (80 mg/kg) was administered i.p.…”

Section: Caffeinementioning

confidence: 86%

Role of Radioprotectors in the Inhibition of DNA Damage and Modulation of DNA Repair After Exposure to Gamma-Radiation

Devasagayam¹

2011

Selected Topics in DNA Repair

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Radioprotection by caffeine pre- and post-treatment in the bone marrow chromosomes of mice given whole-body γ-irradiation

Cited by 30 publications

References 28 publications

Pharmacological potential of methylxanthines: Retrospective analysis and future expectations

Pharmacological potential of methylxanthines: Retrospective analysis and future expectations

Utilization of cytogenetic biomarkers as a tool for assessment of radiation injury and evaluation of radiomodulatory effects of various medicinal plants – a review

Role of Radioprotectors in the Inhibition of DNA Damage and Modulation of DNA Repair After Exposure to Gamma-Radiation

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Radioprotection by caffeine pre- and post-treatment in the bone marrow chromosomes of mice given whole-body γ-irradiation

Cited by 30 publications

References 28 publications

Pharmacological potential of methylxanthines: Retrospective analysis and future expectations

Pharmacological potential of methylxanthines: Retrospective analysis and future expectations

Utilization of cytogenetic biomarkers as a tool for assessment of radiation injury and evaluation of radiomodulatory effects of various medicinal plants &ndash; a review

Role of Radioprotectors in the Inhibition of DNA Damage and Modulation of DNA Repair After Exposure to Gamma-Radiation

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Utilization of cytogenetic biomarkers as a tool for assessment of radiation injury and evaluation of radiomodulatory effects of various medicinal plants – a review