Radiopharmaceuticals labelled with bromine isotopes

Mazièré, B.; Loc’h, Christian

doi:10.1016/0883-2889(86)90264-9

Cited by 45 publications

(21 citation statements)

References 89 publications

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“…The neutron deficient radioisotopes of bromine have found some use in nuclear medicine, mainly due to a chemical behavior which is conducive to the synthesis of radiopharmacuticals [1][2][3][4][5][6]. Of all bromine radioisotopes the properties of 77 Br (T 1/2 = 56 h) are very suitable for in vivo studies.…”

Section: Introductionmentioning

confidence: 98%

A critical survey of experimental cross section data, comparison with nuclear model calculations and estimation of production yields of 77Br and 77Kr in no-carrier-added form via various nuclear processes

Hassan

Qaim

2011

Nuclear Instruments and Methods in Physics Research Section B:

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Section: Introductionmentioning

confidence: 98%

A critical survey of experimental cross section data, comparison with nuclear model calculations and estimation of production yields of 77Br and 77Kr in no-carrier-added form via various nuclear processes

Hassan

Qaim

2011

Nuclear Instruments and Methods in Physics Research Section B:

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“…The high nucleophilicity of bromide bears advantages in synthesis of radiolabelled compounds, and n.c.a. products via interhalogen-exchange can be obtained easily [2][3][4]. Further, it can rather easily be oxidised in situ, thus facilitating n.c.a.…”

Section: Introductionmentioning

confidence: 97%

“…There is a longstanding interest in the radioisotopes of bromine for application in nuclear medicine [1][2][3][4][5]. This is based on their versatile decay properties and covalent chemical bonding.…”

Section: Introductionmentioning

confidence: 99%

New cross section measurements for production of the positron emitters 75Br and 76Br via intermediate energy proton induced reactions

et al. 2009

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75 Br / 76 Br / Intermediate energy / Proton induced reactions / Excitation function / Integral yield Summary. The radionuclides 75 Br and 76 Br are of considerable interest for application in Positron Emission Tomography (PET). For their production so far mostly low-energy or low-yield production processes have been employed. In this work the production of both isotopes was investigated using intermediate energy proton induced reactions and enriched target materials. Cross section data of the 77,78,80 Se( p, xn) 75 Br processes were measured up to 66 MeV and those of the 77,78,80 Se( p, xn) 76 Br processes up to 85 MeV. The measured excitation functions were compared with calculated results of the nuclear model code ALICE-IPPE. From the experimental excitation curves, thick target yields were calculated. They are fairly high over the investigated intermediate energy ranges. The production possibilities of 75 Br and 76 Br via various routes and the radionuclidic impurities associated with them are discussed.

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“…Several radioisotopes of bromine have found applications in labeling biomolecules [4,5,6]. 75 Br with its convenient half-life of 99 min together with its high β + emission rate (76%) and a * Author for· correspondence.…”

Section: Introductionmentioning

confidence: 99%

Production and Purification of ⁷⁷Br Suitable for Labeling Monoclonal Antibodies Used in Tumor Imaging

Lambert

Slegers

Hermanne³

et al. 1994

Radiochimica Acta

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The irradiation of 400 mg As 2 0 3 with 30 MeV α-particles yields nearly pure "Br resulting from the 75 As (a,2n) 77 Br reaction.y-ray spectroscopy of the irradiated material at EOB + 20 h showed that the radionuclidic purity was >99%. The purification of 77Br from the As 2 0 3 target material is discussed. The irradiated powder is dissolved in boiling water. Anion-exchange column chromatography using Dowex AG 1X8 is performed. The 77 Br is eluted with 1 M NaHSO". The latter is removed by precipitation with methanol. After drying and redissolving the residue in 100 μΐ of water, a 77 Br solution with pH 6-8 is obtained suitable for the labeling of monoclonal antibodies. Recovery experiments with [ 76 As]As 2 0 3 have shown that after anionexchange chromatography less than 10" 5 % of the amount of arsenic is present in the NaHS0 4 aliquot of interest. The chemical state of the radiobromine is checked by 2 methods: HPLC anionchromatography and TLC. Both techniques proved the 77 Br to exist only in the bromide form.

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Radiopharmaceuticals labelled with bromine isotopes

Cited by 45 publications

References 89 publications

A critical survey of experimental cross section data, comparison with nuclear model calculations and estimation of production yields of 77Br and 77Kr in no-carrier-added form via various nuclear processes

A critical survey of experimental cross section data, comparison with nuclear model calculations and estimation of production yields of 77Br and 77Kr in no-carrier-added form via various nuclear processes

New cross section measurements for production of the positron emitters 75Br and 76Br via intermediate energy proton induced reactions

Production and Purification of ⁷⁷Br Suitable for Labeling Monoclonal Antibodies Used in Tumor Imaging

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Radiopharmaceuticals labelled with bromine isotopes

Cited by 45 publications

References 89 publications

A critical survey of experimental cross section data, comparison with nuclear model calculations and estimation of production yields of 77Br and 77Kr in no-carrier-added form via various nuclear processes

A critical survey of experimental cross section data, comparison with nuclear model calculations and estimation of production yields of 77Br and 77Kr in no-carrier-added form via various nuclear processes

New cross section measurements for production of the positron emitters 75Br and 76Br via intermediate energy proton induced reactions

Production and Purification of 77Br Suitable for Labeling Monoclonal Antibodies Used in Tumor Imaging

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Production and Purification of ⁷⁷Br Suitable for Labeling Monoclonal Antibodies Used in Tumor Imaging