Radiopharmaceuticals for studying cardiac metabolism

Antar, Mohamed A.

doi:10.1016/0883-2897(90)90014-r

Cited by 8 publications

(3 citation statements)

References 97 publications

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“…To this end radioisotopes are commonly used tools, yielding quantitative measures of the organ distribution of a drug (Antar, 1990;Kung, 1990; Stocklin, 1992). Noninvasive imaging permits the time sequence monitoring of the distribution of a drug (Antar, 1990;Kung, 1990;Reba, 1993;Stocklin, 1992). However, radio nuclear images may suffer from limited spatial resolution, making it difficult to apply to laboratory animal models such as mice.…”

Section: Introductionmentioning

confidence: 99%

In vivo spin-label murine pharmacodynamics using low-frequency electron paramagnetic resonance imaging

Halpern¹,

Perić²,

Yu³

et al. 1996

Biophysical Journal

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A novel, very-low-frequency electron paramagnetic resonance (EPR) technique is used to image the distribution of several nitroxides with distinct pharmacologic compartment affinities in the abdomens of living mice. Image acquisition is sufficiently rapid to allow a time sequence of the distribution for each compound. The spectra and concentrations of these nitroxides are imaged with the use of spectral-spatial imaging to distinguish a single spatial dimension. Liver and bladder of the mouse anatomy are distinguished by this technique. After an intraperitoneal injection of the spin-label probes, a shift in the distribution of the compounds from the upper abdomen (primarily liver) to the lower abdomen (primarily bladder) is observed. The time dependence of the shift in regional distribution depends on the structural properties of the side chain attached to the spin label. These results indicate that this application of in vivo electron paramagnetic resonance imaging will provide a new method of magnetic resonance imaging for determination of pharmacodynamics in the body of an intact animal.

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Section: Introductionmentioning

confidence: 99%

In vivo spin-label murine pharmacodynamics using low-frequency electron paramagnetic resonance imaging

Halpern¹,

Perić²,

Yu³

et al. 1996

Biophysical Journal

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“…However, the present basic study suggests that myocardial scintigraphy with 123 I-BMIPP can be useful in evaluating myocardial energy metabolism, since myocardial 123 I-BMIPP uptake correlates with concentrations of triglyceride and ATP in myocardial cells, 10 as well as reflecting mitochondrial dysfunction in myocardial cells. 23 Dynamic studies are affected by regional blood flow, triglyceride pool, and back diffusion. Since abnormalities caused by IFN therapy were also observed in a dynamic study, the involvement of certain disorders caused by BMIPP, other than metabolic abnormalities of fatty acids, cannot be ruled out.…”

Section: Discussionmentioning

confidence: 99%

Early diagnosis of interferon-induced myocardial disorder in patients with chronic hepatitis C: evaluation by myocardial imaging with 123 I-BMIPP

Kondo

Yukinaka

Nomura

et al. 2000

Journal of Gastroenterology

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Interferon (IFN) therapy for chronic hepatitis C is sometimes associated with cardiac complications. In the present study, we performed myocardial imaging with 123I-labeled beta-methyl-p-iodophenylpentadecanoic acid (123I-BMIPP) in order to evaluate myocardial disorders caused by IFN. We studied 40 healthy subjects (H group) and 25 patients with chronic hepatitis C who had been treated with IFN (IFN group). A Holter electrocardiogram (ECG) was performed and the autonomic nervous function was assessed by analyzing the spectral variability and 1/f fluctuation of heart rate. Myocardial planner imaging with 123I-BMIPP was performed to obtain the time activity curve for 20min immediately after administration of 123I-BMIPP (dynamic study). Early and delayed myocardial single photon emission computed tomography (SPECT) images were expressed as Bull's eyes and the myocardium was divided into four segments to calculate the washout rate for each segment on early and late SPECT images (early and late SPECT study). No significant differences in autonomic nervous function were observed between the two groups in heart rate variability. In a dynamic study, the reduction rate from the time activity curve was significantly higher in the IFN group compared with the H group (reduction rate, IFN group, 5.3 +/- 3.7% vs H group, 1.2 +/- 3.3%; P < 0.05). In the early and delayed myocardial SPECT study, the washout rate for the IFN group was significantly increased in all myocardial areas compared to that in the H group. However, the metabolic disorder of fatty acids caused by IFN was reversed on the second 123I-BMIPP myocardial scintigraphy examination several months after IFN therapy. These results indicate that metabolic disorders of fatty acids caused by IFN therapy can be detected before abnormalities are observed by Holter-ECG or echocardiography.

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“…A great variety of fatty acids has been prepared and evaluated both for PET and SPET (for reviews, see Schelbert and Schwaiger 1986;Antar 1990, cf. also Second workshop on radiolabelled free fatty acids 1990).…”

Section: Fatty Acidsmentioning

confidence: 99%