Radiopharmaceutical-related pitfalls and artifacts

Hung, Joseph C.; Ponto, James A.; Hammes, Richard J.

doi:10.1016/s0001-2998(96)80002-x

Cited by 51 publications

(39 citation statements)

References 115 publications

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“…If unknown, such factors may lead to poor visualization, a requirement to repeat the procedure resulting in unnecessary irradiation of organs or even misdiagnosis (Hojelse et al, 1994;Hung et al, 1996;Saha, 1998). Knowledge of altered bioavailability of the radiopharmaceuticals due to drug interaction definitely helps the physician to avoid misinterpretation of the scintigraphic images and, thus, an incorrect diagnosis and helps to prevent or treat adequately possible adverse reactions to the radiopharmaceuticals (Hladik et al, 1987;Sampson, 1993).…”

Section: Discussionmentioning

confidence: 99%

“…Many authors have been studying the drug interaction as an important factor that can alter the behavior of the radiopharmaceuticals in different organs and tissues of the animal models (Owunwanne et al, 1998;Mattos et al, 1999;Xavier Holanda et al, 2002;Amorim et al, 2003;Britto et al 2004;. Frequently, this phenomenon is responsible for modification of the bioavailability of the radiopharmaceutical (Owunwanne et al, 1995;Hung et al, 1996;Xavier Holanda et al, 2002;Gomes et al, 2002). Thus, the nuclear medicine practices have increased continually in recent decades.…”

Section: Introductionmentioning

confidence: 99%

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Effect of antimalarial drugs on the bioavailability of the methylenediphosphonic acid labeled with technetium99m (99mTc-MDP) in Wistar rats

Holanda

Leite

Nunes

et al. 2006

Braz. arch. biol. technol.

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%ATI occurred in MQ group:bladder (0.75±0.07to0.26±0.05), stout bowel (2.13±0.34to0.66±0.19), pancreas (0.87±0.24to0.28±0.18), kidneys (7.00±1.52to3.46±0.62), brain (0.27±0.08to 0.05±0.01) and also in AM group:bladder (0.75±0.07to0.30±0.05), stout bowel (2.13±0.34to0.36±0.08), muscle (2.04±0.39to0.26±0.06), pancreas (0.87±0.24to0.46±0.12) and kidneys (7.00±1.52to4.35±0.28). These results could be associated to biological effects of antimalarial drugs.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of antimalarial drugs on the bioavailability of the methylenediphosphonic acid labeled with technetium99m (99mTc-MDP) in Wistar rats

Holanda

Leite

Nunes

et al. 2006

Braz. arch. biol. technol.

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“…The significant difference in RCP values between the Cardiolite preparations and its generic medicine, the Stamicis preparation, is not easy to explain. However, the use of highdissolved-oxygen standard saline has been described as an artifact in the stability of radiopharmaceuticals because dissolved oxygen promotes formation of peroxide and hydroperoxy radicals (23). Thus, a greater dilution volume with standard saline for the Stamicis preparations compared with Cardiolite might be an explanation for the higher RCP failure rate observed with Stamicis.…”

Section: Discussionmentioning

confidence: 99%

The Presence of Sodium Nitrate in Generator Eluate Decreases the Radiochemical Purity of 99mTc-Sestamibi

Métayé¹,

Rosenberg²,

Guilhot

et al. 2012

Journal of Nuclear Medicine Technology

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A high radiochemical purity (RCP) is recommended for radiopharmaceutical compounds used in the clinical practice of nuclear medicine. However, some preparations of 99m Tc-sestamibi contain excess impurities (.6%). To understand the origin of these impurities, we investigated the effect of sodium nitrate on the RCP of sestamibi preparations by testing eluates from 3 commercially available 99m Tc generators. Methods: The sestamibi kits (Stamicis) were reconstituted with 99m Tc eluate from nitrate-containing wet-column (NCWC), nitrate-free wet-column (NFWC), and nitrate-free dry-column (NFDC) generators. Sodium nitrate was 0.05 mg/mL in eluates from the NCWC generators. The RCP was determined using aluminum oxide sheets as the stationary phase and absolute ethanol as the mobile phase. Succimer, tetrofosmin, oxidronate, exametazine, albumin nanocolloid, and soluble albumin were also tested for their RCP values with eluates from the 3 different 99m Tc generators. Results: The RCP assessment of 99m Tc-sestamibi was performed on 127 Stamicis preparations. Significantly lower RCP values were found for Stamicis kits prepared with the NCWC generator than for Stamicis prepared with the NFWC (P , 0.0001) and NFDC (P , 0.0001) generators. The number of Stamicis preparations with an RCP under 94% was greater with the NCWC generator (32 of 53 kits) than with the NFDC (2 of 51 kits) or NFWC (0 of 23 kits) generator. Furthermore, the addition of a 0.05 mg/mL concentration of nitrate in NFWC generator eluates significantly decreased the RCP of the Stamicis preparation. In the absence of nitrate in 99m Tc eluate, no difference was observed between the RCP values of Stamicis kits prepared with the NFWC and NFDC generators. The 99m Tc impurities generated by nitrates did not modify the quality of myocardial imaging (normal heart-to-lung ratio, 2.2), probably because these impurities are not in the heart field of view. No other tested 99m Tcradiopharmaceutical interfered with nitrates. Conclusion: We recommend using nitrate-free generator eluates in 99m Tc-sestamibi preparations to improve the product quality and prevent unnecessary exposure of the patient to radiation. Sest amibi labeled with 99m Tc ( 99m Tc-2-methoxyisobutylisonitril, or MIBI) is a lipophilic cationic complex originally developed as a myocardial perfusion imaging agent (1-4) and subsequently used for parathyroid (5) and tumor (6) imaging. Ninety-five percent of intracellular 99m Tc-sestamibi is retained in the mitochondria. Its uptake involves a passive distribution across plasma and mitochondrial membranes, but its retention depends mainly on the large negative transmembrane potential of mitochondria (7). 99m Tc-sestamibi is also a transport substance recognized by the multidrug resistance-related P glycoprotein, and its tumor cell accumulation is enhanced by inhibition of the efflux transport function. This property provided the basis for clinical studies that investigated the role of 99m Tc-sestamibi in predicting the response to chemotherapy in patients with ca...

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“…1 Over the years, their review has proved to be an extremely useful reference in nuclear medicine practice. The present review does not seek to cover the same ground, as much of the material remains relevant and the main points are summarized in Table 1.…”

Section: N 1996 Joseph Hung James Ponto and Richardmentioning

confidence: 99%