Radiopathology of Americium 241: I. Distribution of Americium in Adult Mice

Hammarström, Lars; Nilsson, A.

doi:10.3109/02841867009129119

Cited by 7 publications

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“…041 ± These concentrations of 241 Am are lower by a factor of 6 and 10 than those of liver and skeleton, respectively . Taking into account, however, the apparent long residence time, the possibility of non-uniform distribution (Hammarstrom and Nilsson 1970) and, thus, of radiation dose and the toxicological data mentioned at the outset, the 241 Am-deposition in the endocrine organs might possibly be of some importance . This is particularly true of the ovaries : owing to the relatively poor response to treatment, the 241 Am-concentration in that organ (about 0 .…”

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“…skeleton and/or liver . Recently, pathological lesions and neoplasms of some endocrine organs as well as an influence of 241 Am on the reproductive ability have been reported (Hammarstrom and Nilsson 1970, Ovcharenko 1972a, b, Rudnitskaya and Moskalev 1970, Taylor and Bensted 1969 ; there are, however, only few and inconsistent observations relating to the retention of 241 Am by endocrine organs of rodents (McKay, Brooks and McClellan 1972, Seidel and Volf 1972b, Zalikin, Moskalev and Petrovich 1968 . Data on the effect of DTPA (diethylenetriaminepentaacetate) are also limited (Johnson, Watters, Level, Lagerquist andHammond 1971, Seidel andVolf 1972 b) .…”

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Retention of²⁴¹Am by Some Endocrine Organs of the Rat and Its Response to DPTA-treatment

Seidel

1973

International Journal of Radiation Biology and Related Studies

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Studies in the metabolism of 241 Am are usually concerned with its retention by the alleged critical organ(s), i .e . skeleton and/or liver . Recently, pathological lesions and neoplasms of some endocrine organs as well as an influence of 241 Am on the reproductive ability have been reported (Hammarstrom and Nilsson 1970, Ovcharenko 1972 a, b, Rudnitskaya and Moskalev 1970, Taylor and Bensted 1969 ; there are, however, only few and inconsistent observations relating to the retention of 241 Am by endocrine organs of rodents (McKay, Brooks and McClellan 1972, Seidel and Volf 1972 b, Zalikin, Moskalev and Petrovich 1968 . Data on the effect of DTPA (diethylenetriaminepentaacetate) are also limited (Johnson, Watters, Level, Lagerquist and Hammond 1971, Seidel and Volf 1972 b) . The present study deals with the retention of 241 Am by some endocrine organs of the rat as influenced by treatment with Ca-DTPA and (for reasons to be discussed elsewhere (Seidel and Volf 1972 b)) with Zn-DTPA.Female albino rats (175-205 g) were injected intravenously with 0 . 3-0 . 6 µCi 241 Am-citrate (pH 7 . 5-8 . 5) . Treated animals received 12 intraperitoneal injections of Ca-or Zn-DTPA (30 µmol . kg-1 ) as indicated in the table . The animals were killed 7 days after the last DTPA-dose . Details of the assay of a-activity of the organs are described elsewhere (Seidel and Volf 1972 a) .Influence of DTPA-treatment on the 241 Am-content of thyroid and ovaries of the rat (percentage of the control) . Arithmetic means ± S .E. (calculated according to. Parrat (1961)) ; three to six rats per group . Treatment schedule I : DTPA (30 µmol . kg -') after 1 . 5 min, 24 hours, 8, 15, 22, 29, 36, 43, 50, 57, 64, and 71 days . Treatment schedule II : DTPA (30 µmol . kg-1 . d-1 ) after 4, 11, 18, 25, 32, 39, 46, 53, 60, 67, 74, and 81 days .As can be seen from the figure, no significant elimination from the organs of control animals is observed after the 15th day . Owing to the small mass of the organs, the concentrations (per cent of the 241 Am-dose . g-1 fresh weight) are higher and amount, on the 78th day, for instance, to 0 . 029 ± 0 . 003, 0. 041 ± Thyroid Ovaries Treatment I II I II Ca-DTPA 8±3 23±4 17±0 40±6 Zn-DTPA 8+2 23 ± 3 21+4 38 ± 5 Int J Radiat Biol Downloaded from informahealthcare.com by UB Mainz on 11/05/14For personal use only.

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Retention of²⁴¹Am by Some Endocrine Organs of the Rat and Its Response to DPTA-treatment

Seidel

1973

International Journal of Radiation Biology and Related Studies

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Effects of Metals on Male Reproduction

Berlin

Lee

Russell

1983

Reproductive and Developmental Toxicity of Metals

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Microdistribution and Localized Dosimetry of²⁴¹Am in Bones of Beagle Dogs

Polig¹,

Smith²,

Jee³

1984

International Journal of Radiation Biology and Related Studies

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The microdistribution of 241Am in selected bones of seven beagle dogs was analysed using a computer controlled microscope photometer. Four of the animals receiving between 102.5 and 165 kBq/kg were killed between 7 and 20 days after injection, and three animals receiving 32.9-34.0 kBq/kg were killed between 1300 and 1569 days. Using the photometric scanning technique, the concentrations of 241Am in several anatomical regions, as well as the specific surface activities and their variations, dose rates, accumulated radiation doses, burial depths and morphometric parameters, were derived. Dose rates to the 0-10 micron marrow band adjacent to surfaces were found to be between 8.6 and 15.7 times higher than the average skeletal dose. Accumulated radiation doses from initial deposits to lining cells were estimated to be between 87 and 252 Gy. The average burial depth in the animals killed at later times was around 8 micron. Morphometric parameters showed that radiation damage occurred in these animals, resulting in abnormal trabecular architecture. A positive correlation between specific surface activity and local turnover rates was established.

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Radiopathology of Americium 241: I. Distribution of Americium in Adult Mice

Cited by 7 publications

References 7 publications

Retention of²⁴¹Am by Some Endocrine Organs of the Rat and Its Response to DPTA-treatment

Retention of²⁴¹Am by Some Endocrine Organs of the Rat and Its Response to DPTA-treatment

Effects of Metals on Male Reproduction

Microdistribution and Localized Dosimetry of²⁴¹Am in Bones of Beagle Dogs

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Radiopathology of Americium 241: I. Distribution of Americium in Adult Mice

Cited by 7 publications

References 7 publications

Retention of241Am by Some Endocrine Organs of the Rat and Its Response to DPTA-treatment

Retention of241Am by Some Endocrine Organs of the Rat and Its Response to DPTA-treatment

Effects of Metals on Male Reproduction

Microdistribution and Localized Dosimetry of241Am in Bones of Beagle Dogs

Contact Info

Product

Resources

About

Retention of²⁴¹Am by Some Endocrine Organs of the Rat and Its Response to DPTA-treatment

Retention of²⁴¹Am by Some Endocrine Organs of the Rat and Its Response to DPTA-treatment

Microdistribution and Localized Dosimetry of²⁴¹Am in Bones of Beagle Dogs