Radionuclide regurgitant index: Value and limitations

Lam, Wilfred; Pavel, Dan G.; Byrom, Ernest; Sheikh, Amjad I.; Best, David; Rosen, Kenneth M.

doi:10.1016/0002-9149(81)90400-8

Cited by 67 publications

(8 citation statements)

References 8 publications

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“…Rigo et al li] introduced the concept of calculating the regurgitant fraction by comparing the stroke counts of the two ventricles. Our results and data from the literature' 7 " 131 contribute to demonstrate the clinical usefulness of this simple principle.…”

Section: Discussionsupporting

confidence: 54%

Quantification of valvular regurgitation by cardiac blood pool scintigraphy: correlation with catheterization

Melchior

Chevigné

Righetti

et al. 1987

European Heart Journal

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The diagnosis of valvular regurgitation (R) is usually based on clinical signs. Quantification conventionally requires catheterization (C). We have quantified R with cardiac blood pool scintigraphy (CBPS) and compared the results with those obtained by C. Regurgitant fraction (RF) determined by C was calculated with the technique of Dodge. Forward output was measured by thermodilution or cardiogreen dilution. The RF at CBPS was obtained by the stroke index ratio (SIR) minus 1-2 divided by SIR, where SIR is the ratio of the stroke counts of left venticle over those of the right ventricle. Stroke counts are calculated directly from the timeactivity curves. Each time-activity curve was obtained by drawing one region of interest around each diastolic image. The correction factor (1-2) was calculated from a large normal population. 22 patients had aortic R, 7 mitral R, 12 both, 8 patients had no evidence of regurgitation. RF of the patients with R varied from 27 to 71% (x = 42%) at C and from 26 to 74% (y = 41%) at CBPS. Linear regression shows a good correlation coefficient (r = 0-82). The regression equation is y = 0-93x + 1-8. No correlation was found between RF (CBPS or C)and the severity of R assessed visually from angiography. In conclusion: CBPS, a non-invasive method, allows easy and repeatable determination of RF and correlates well with data obtained at catheterization.

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Section: Discussionsupporting

confidence: 54%

Quantification of valvular regurgitation by cardiac blood pool scintigraphy: correlation with catheterization

Melchior

Chevigné

Righetti

et al. 1987

European Heart Journal

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“…10 Moreover, since the ratio of RNA right to left ventricular stroke counts accurately estimates contrast cineangiographic regurgitant fraction in patients with mitral or aortic regurgitation, it is reasonable to assume that RNA count data can provide estimates of right ventricular size. [11][12][13][14] Furthermore, RNA right and left ventricular ejection fraction (EF) measures have correlated closely with those obtained from other noninvasive and invasive techniques. [15][16][17][18][19] Recently, Bommer and co-investigators20 reported that two-dimensional (2-D) echocardiographic crosssectional area measurements of right ventricular cast preparations correlated highly with actual cast volume measurements determined by water displacement.…”

mentioning

confidence: 74%

A new two-dimensional echocardiographic technique for evaluating right ventricular size and performance in patients with obstructive lung disease.

Starling¹,

Crawford²,

Sorensen³

et al. 1982

Circulation

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SUMMARY To compare two-dimensional (2-D) echocardiographic estimates of right ventricular size and performance to similar determinations from equilibrium radionuclide angiography (RNA) before and after isosorbide dinitrate, we evaluated 19 patients with severe chronic obstructive pulmonary disease. The enddiastolic and end-systolic volumes estimated from subcostal 2-D echocardiographic views of the right ventricle correlated with the RNA end-diastolic and end-systolic counts (r = 0.76 and 0.82, respectively). The 2-D echocardiographic and RNA right ventricular ejection fraction (EF)

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“…Due to some limitations based mainly in the overlap of right atrium and right ventricle, the significance of this technique is not yet clearly defined (Kress et al 1981;Lam et al 1981 ;Sorensen et al 1980; Thompson et al 1981;Urquhart et al 1981). In order to overcome these difficulties, some authors introduced modifications by using a slant hole collimator (Gandsman et al 1981), calculating left to right ventricular stroke count ratios directly from functional images (Gerson et al 1984;Makler et al 1983 ;Nicod et al 1982), correcting for right atrial overlap (Berthout et al 1984;Henze et al 1982) or combining first pass and equilibrium radionuclide ventriculography (Klepzig et al 1985 a).…”

Section: Offprint Requests To E Vothmentioning

confidence: 99%

Significance of gated equilibrium radionuclide ventriculography in quantification and follow up of valvular regurgitation

et al. 1988

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Abstract. In order to evaluate the significance of gated equilibrium radionuclide ventriculography (RNV) for non invasive quantification of valvular regurgitation and follow up, various approaches were tested concerning accuracy and reproducibility.By using in vitro labeling of red blood cells and extending the acquisition time, a clear reduction of dispersion was obtained in patients without valvular insufficiency. Quantification of regurgitation directly from functional images (ventricular amplitude or stroke volume image) was clearly superior compared to the variable region of interest method. Employing functional images, reproducibility between two observers and between two independent measurements was excellent. Correlation to regurgitation values determined by cardiac catheterization was only moderate with all RNV approaches tested.RNV is limited in the absolute quantification of valvular regurgitation due to the variable overlap of right atrium and right ventricle. However, because of its high reproducibility, RNV is a non invasive technique suitable for intraindividual follow up of patients with valvular insufficiency.

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Radionuclide regurgitant index: Value and limitations

Cited by 67 publications

References 8 publications

Quantification of valvular regurgitation by cardiac blood pool scintigraphy: correlation with catheterization

Quantification of valvular regurgitation by cardiac blood pool scintigraphy: correlation with catheterization

A new two-dimensional echocardiographic technique for evaluating right ventricular size and performance in patients with obstructive lung disease.

Significance of gated equilibrium radionuclide ventriculography in quantification and follow up of valvular regurgitation

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