Radionuclide Infection Imaging: Conventional to Hybrid

Gallium-67 Scintigraphy in the Era of Positron Emission Tomography and Computed Tomography: Tertiary centre experience

“…4,5 67 Ga citrate was used extensively in the past for several pathological conditions, particularly when the presence of tumours, infection or inflammation was in question. 3 In past decades, the role of 67 Ga scintigraphy in nuclear oncology mainly focused on assessing the response of lymphoma to therapy. However, it was also used as a baseline for staging and to assess gallium avidity, patient response to treatment and residual disease activity post-therapy.…”

“…In addition, 67 Ga has been successfully utilised in the evaluation of spinal discitis and vertebral osteomyelitis, mainly to assess disease activity. 3 Technetium-99m ( 99m Tc) sulesomab is another modality for evaluating infection and can be used instead of 67 Ga in most indications. 15 This antigranulocyte antigen-binding fragment has been…”

“…One of the most commonly used radioisotopes in tumour imaging, as well as in the imaging of infection and inflammation, is gallium-67 citrate ( 67 Ga). 3 This group IIIA metal has been used for decades for the imaging of various solid neoplasms, particularly lymphomas, and in the investigation of acute inflammatory conditions. It is also used to assess infections and to identify the site of disease in patients with pyrexia of unknown origin (PUO).…”

“…For medical radiology purposes, 67 Ga is provided in the form of a sterile solution of gallium citrate. 3,5,6 The human body reacts to 67 Ga similarly to the way that it handles ferric iron. Gallium III ions bind to transferrin glycoproteins, leukocyte lactoferrin, bacterial siderophores, inflammatory proteins and cell membranes in neutrophils and become concentrated in areas of inflammation and rapid cell division.…”

“…Gallium III ions bind to transferrin glycoproteins, leukocyte lactoferrin, bacterial siderophores, inflammatory proteins and cell membranes in neutrophils and become concentrated in areas of inflammation and rapid cell division. 3,7 This retrospective study aimed to evaluate the use of 67 Ga in a tertiary care hospital over a period of five years and compare outcomes with available clinical and radiological follow-up data, including CT and PET/CT scans and biopsies.…”