Radionuclide angiographic evaluation of left ventricular function by resting ejection rate during the first third of systole in patients with chronic aortic regurgitation

The influence of left ventricular volume variations and regurgitant fraction variations upon left ventricular ejection fraction during exercise was examined using equilibrium radionuclide angiography in patients suffering from aortic regurgitation. Ejection fraction (EF), regurgitant fraction (RF), end diastolic volume (EDV) and end systolic volume (ESV) variations from rest to peak exercise were determined in 44 patients suffering from chronic aortic regurgitation (AR) and in 8 healthy volunteers (C). In C, EF increased (+0.10 +/- 0.03, P less than 0.01) and ESV decreased significantly (-23% +/- 12%, P less than 0.01), RF and EDV did not vary significantly. In AR patients, EF, EDV and ESV did not vary significantly because of important scattering of individual values. Changes in EF and ESV were inversely correlated (r = -0.79, P less than 0.01) and RF decreased significantly (-0.12 +/- 0.10, P less than 0.01). Volumes and EF changes during exercise occurred in three different ways. In a 1st subgroup of 7 patients, EF increased (+0.09 +/- 0.03, P less than 0.05) in conjunction with a reduction of ESV (-24% +/- 12%, P less than 0.05) without a significant change in EDV. In a 2nd group of 22 patients, EF decreased (-0.04 +/- 0.07, P less than 0.01) in association with an increase in ESV (+17% +/- 16%, P less than 0.01) and no change in EDV. In a 2nd group of 22 patients, EF decreased (-0.04 +/- 0.07, P less than 0.01) in association with an increase in ESV (+17% +/- 16%, P less than 0.01) and no change in EDV. In a 3rd subgroup of 15 patients, EF decreased (-0.02 +/- 0.06, P less than 0.01) despite a reduction in ESV (-7% +/- 6%, P less than 0.01) because of a dramatic EDV decrease (-10% +/- 6%, P less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)

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Factors influencing the variations of ejection fraction during exercise in chronic aortic regurgitation

Bassand

Faivre

Berthout

et al. 1987

Eur J Nucl Med

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Use of left ventricular filling and ejection patterns in assessing severity of chronic mitral and aortic regurgitation

Osbakken

Bové

1984

The American Journal of Cardiology

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Part II: Radionuclide evaluation of aortic regurgitation

Miller¹

1990

Current Problems in Cardiology

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Radionuclide angiographic evaluation of left ventricular function by resting ejection rate during the first third of systole in patients with chronic aortic regurgitation

Cited by 4 publications

References 16 publications

Factors influencing the variations of ejection fraction during exercise in chronic aortic regurgitation

Factors influencing the variations of ejection fraction during exercise in chronic aortic regurgitation

Use of left ventricular filling and ejection patterns in assessing severity of chronic mitral and aortic regurgitation

Part II: Radionuclide evaluation of aortic regurgitation

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