Radiomics Approach Outperforms Diameter Criteria for Predicting Pathological Lateral Lymph Node Metastasis After Neoadjuvant (Chemo)Radiotherapy in Advanced Low Rectal Cancer

Nakanishi, Ryota; Akiyoshi, Takashi; Toda, Shigeo; Murakami, Yu; Taguchi, Senzo; Oba, Koji; Hanaoka, Yutaka; Nagasaki, Toshiya; Yamaguchi, Takahiro; Konishi, Tsuyoshi; Matoba, Shuichiro; Ueno, Masashi; Fukunaga, Yosuke; Kuroyanagi, Hiroya

doi:10.1245/s10434-020-08974-w

Cited by 47 publications

(35 citation statements)

References 39 publications

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“…For colorectal liver metastasis, radiomics showed promising performance in predicting overall survival [ 29 ], disease-free survival [ 30 ], response to targeted therapies [ 31 ], the outcome for patients with unresectable hepatic metastases [ 32 ], or recurrence after liver resection [ 33 ]. In rectal cancer, radiomics were shown to be correlated with tumor regression [ 34 ], lymph node metastasis [ 35 , 36 ] or response after chemoradiation therapy [ 37 , 38 ].…”

Section: Radiomicsmentioning

confidence: 99%

Radiogenomics in Colorectal Cancer

Badic

Tixier

Rest

et al. 2021

Cancers

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The steady improvement of high-throughput technologies greatly facilitates the implementation of personalized precision medicine. Characterization of tumor heterogeneity through image-derived features—radiomics and genetic profile modifications—genomics, is a rapidly evolving field known as radiogenomics. Various radiogenomics studies have been dedicated to colorectal cancer so far, highlighting the potential of these approaches to enhance clinical decision-making. In this review, a general outline of colorectal radiogenomics literature is provided, discussing the current limitations and suggested further developments.

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Section: Radiomicsmentioning

confidence: 99%

Radiogenomics in Colorectal Cancer

Badic

Tixier

Rest

et al. 2021

Cancers

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“…Ryota et al. evaluated 247 patients with enlarged LPLNs who received (chemo)radiotherapy and LPLD, and found that the pretreatment short axis had good discrimination for LPLN metastasis ( 23 ). Atsushi et al.…”

Section: Discussionmentioning

confidence: 99%

Simultaneous Integrated Boost Intensity-Modulated Radiation Therapy Can Benefit the Locally Advanced Rectal Cancer Patients With Clinically Positive Lateral Pelvic Lymph Node

Zhang

et al. 2021

Front. Oncol.

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Background and PurposeThe optimal treatment modality for clinically positive lateral pelvic lymph node (LPLN) from locally advanced rectal cancer (LARC) is unknown. Thus, we aimed to analyze the optimal radiotherapy dose for clinically positive LPLN from LARC.Materials and MethodsWe retrospectively evaluated distal LARC (i.e., within 8 cm from the anal verge) patients with clinically positive LPLN (i.e., ≥7 mm in the short axis). They were divided into two groups based on whether or not they received simultaneous integrated boost intensity-modulated radiation therapy (SIB-IMRT)–based chemoradiotherapy. The total radiotherapy dose on LPLN were 56-60Gy for SIB-IMRT group and 41.8Gy for non-SIB-IMRT group. The clinical parameters and regrowth rate of LPLN were then compared between the two groups.ResultsA total of 151 patients were evaluated, and 83 and 68 patients were classified to the SIB-IMRT and non-SIB-IMRT group, respectively. The median follow-up period was 22.6 months, and the 2-year LPLN regrowth rate was significantly different between the SIB-IMRT group and the non-SIB-IMRT group (0% vs 10.8%, P=0.024). Further, SIB-IMRT yielded a significantly lower 2-year LPLN regrowth rate in patients whose LPLN measured ≥8 mm in the short axis (0% vs. 15.9%, P=0.019) or ≥10 mm in the long axis (0% vs. 17.6%, P=0.024) compared to patients who were in non-SIB-IMRT group. Meanwhile, there was no significant difference in grade II radiation-related toxicity (30.1% vs. 39.1%, P=0.217) and surgical complications (21.8% vs. 12.2%, P=0.198) between the two groups.ConclusionSIB-IMRT–based neoadjuvant chemoradiotherapy is beneficial for eliminating clinically positive LPLN from LARC without increasing the incidence of radiotherapy-related toxicity and surgical complications, and patients with larger LPLN may gain benefit from this technique.

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“…According to the principle of con rmatory analysis, independent data sets are needed to verify the results of the training set [108]. Only 51 articles (75%) used independent dataset validation, including 5 [22][23][24][25][26] articles using dual-center validation sets and 7 [12,[16][17][18][19][20][21] articles using multicenter validation sets.…”

Section: Discussionmentioning

confidence: 99%

“…Multicenter research can fully re ect the overall situation and evaluate the generalization ability of the model. Of all the studies, only 7 [12,[16][17][18][19][20][21] (10%) conducted multicenter studies and 5 [22][23][24][25][26] (7%) were dual-center studies.…”

Section: Review Strategymentioning

confidence: 99%

Repeatability of Radiomics Studies in Colorectal Cancer: A Systematic Review

Liu

Wei

et al. 2022

Preprint

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Purpose: Recently, radiomics has been widely used in colorectal cancer, but many variable factors affect the repeatability of radiomics research. This review aims to analyze the repeatability of radiomics studies in colorectal cancer and to evaluate the current status of radiomics in the field of colorectal cancer.Methods: A total of 68 eligible studies was included in this review by searching from the PubMed and EmBase databases. Then each study in our review was evaluated using the Radiomics Quality Score (RQS). We analyzed the factors that may affect the repeatability in the radiomics workflow and discussed the repeatability of the included researches.Results: A total of 68 articles was included in this review, of which only 2 (3%) articles controlled the influence of individual factors, just 2 (3%) articles considered the variability between scanners. In addition, the median score of RQS was 12(out of 36), range −7 to + 28. Conclusions: The RQS score was moderately low, and most studies did not consider the repeatability of radiomics features, especially in terms of Intra-individual, scanners, and scanning parameters. In order to improve the generalization of the radiomics model, it is necessary to further control the variable factors of repeatability.

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Radiomics Approach Outperforms Diameter Criteria for Predicting Pathological Lateral Lymph Node Metastasis After Neoadjuvant (Chemo)Radiotherapy in Advanced Low Rectal Cancer

Cited by 47 publications

References 39 publications

Radiogenomics in Colorectal Cancer

Radiogenomics in Colorectal Cancer

Simultaneous Integrated Boost Intensity-Modulated Radiation Therapy Can Benefit the Locally Advanced Rectal Cancer Patients With Clinically Positive Lateral Pelvic Lymph Node

Repeatability of Radiomics Studies in Colorectal Cancer: A Systematic Review

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