Radiomercury-Labelled Chlormerodrin for in Vivo Uptake Studies and Scintillation Scanning of Unilateral Renal Lesions Associated With Hypertension

Rc, Reba; Jg, McAfee; Hn, Wagner

doi:10.1097/00005792-196307000-00002

Cited by 42 publications

(16 citation statements)

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“…Mercury ( 197 Hg and 203 Hg)-labeled chlormerodrin, introduced by Reba et al (1962a, 1962b), was the main radiopharmaceutical for renal imaging in the 1960s. The key informants reported a wide use of 131 I-iodohippurate for renal imaging in the mid-1960s to mid-1980s.…”

Section: Resultsmentioning

confidence: 99%

Use of Radiopharmaceuticals in Diagnostic Nuclear Medicine in the United States

Drozdovitch¹,

Brill²,

Callahan³

et al. 2015

Health Physics

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To reconstruct reliable nuclear medicine-related occupational radiation doses or doses received as patients from radiopharmaceuticals over the last five decades, we assessed which radiopharmaceuticals were used in different time periods, their relative frequency of use, and typical values of the administered activity. This paper presents data on the changing patterns of clinical use of radiopharmaceuticals and documents the range of activity administered to adult patients undergoing diagnostic nuclear medicine procedures in the U.S. between 1960 and 2010. Data are presented for 15 diagnostic imaging procedures that include thyroid scan and thyroid uptake, brain scan, brain blood flow, lung perfusion and ventilation, bone, liver, hepatobiliary, bone marrow, pancreas, and kidney scans, cardiac imaging procedures, tumor localization studies, localization of gastrointestinal bleeding, and non-imaging studies of blood volume and iron metabolism. Data on the relative use of radiopharmaceuticals were collected using key informant interviews and comprehensive literature reviews of typical administered activities of these diagnostic nuclear medicine studies. Responses of key informants on relative use of radiopharmaceuticals are in agreement with published literature. Results of this study will be used for retrospective reconstruction of occupational and personal medical radiation doses from diagnostic radiopharmaceuticals to members of the U.S. radiologic technologist’s cohort and in reconstructing radiation doses from occupational or patient radiation exposures to other U.S. workers or patient populations.

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Section: Resultsmentioning

confidence: 99%

Use of Radiopharmaceuticals in Diagnostic Nuclear Medicine in the United States

Drozdovitch¹,

Brill²,

Callahan³

et al. 2015

Health Physics

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“…As yet the most reliable screening procedure used in our patients has been carried out with radioactive mercurial compounds, the scintiscan and speed of uptake being the criteria. 22 And this procedure is useful only when negative, for many patients who did not have renal ischemia causing their hypertension have shown abnormalities; but so far all but three of our proved 32 cases since the test has been available (operation performed and normotension resulting) have had an abnormal test with this procedure, an error of 10 per cent. The test is not disagreeable to the patient, offers no halzard, and is not time-consuming.…”

Section: Studies Of Differential Renal Functionmentioning

confidence: 83%

Hypertension as Related to Renal Ischemia

Howard

1964

Circulation

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“…The chlormerodrin uptake curve Immediately following the administration of '97Hg chlormerodrin there is an immediate rise in count rate over both kidneys followed by a more gradual rise over the next 2-3 hr due to accumulation and retention of the radiopharmaceutical by the tubular cells (Reba, McAfee & Wagner, 1963;McAfee, Reba & Chodos, 1967). The rate of uptake is dependent on effective renal blood flow.…”

Section: Clinical Utilization Renographymentioning

confidence: 99%

The investigation of renal disease using radionuclides

Atkins

Freeman

1973

Postgraduate Medical Journal

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Summary The use of radioactive labels for tracers is an important part of the investigation of renal disease. These techniques seldom replace, but often complement radiographic techniques. Generally, the radionuclide methods provide functional and dynamic information in a non-invasive, non-traumatic type of examination. The examinations usually are relatively simple to perform and carry a very low risk of untoward reaction. The past decade has seen significant advances in radiopharmaceutical design and instrumentation. It is expected that the next decade will produce an even greater advance in this field.

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Radiomercury-Labelled Chlormerodrin for in Vivo Uptake Studies and Scintillation Scanning of Unilateral Renal Lesions Associated With Hypertension

Cited by 42 publications

References 0 publications

Use of Radiopharmaceuticals in Diagnostic Nuclear Medicine in the United States

Use of Radiopharmaceuticals in Diagnostic Nuclear Medicine in the United States

Hypertension as Related to Renal Ischemia

The investigation of renal disease using radionuclides

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