Radiolucent cage for cervical vertebral reconstruction: A prospective study of 17 cases with 2-year minimum follow-up

Soderlund, Christian; Pointillart, Vincent; Pedram, M.; Andrault, G.; Vital, Jean-Marc

doi:10.1007/s00586-004-0747-8

Cited by 12 publications

(8 citation statements)

References 25 publications

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“…18,19 Although cervical fusion cages that are made of PLA generally work very well, 15,17,20,21 the acidic degradation products of PLA can cause asepsis inflammation and osteolysis, [22][23][24] which will deteriorate the microenvironment of bone healing. In addition, PLA cannot offer the capacity to osteoconduct.…”

Section: Discussionmentioning

confidence: 99%

Bioabsorbable self-retaining PLA/nano-sized β-TCP cervical spine interbody fusion cage in goat models: an in vivo study

Cao¹,

Chen²,

Jiang³

et al. 2017

IJN

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Study design This is an experimental animal study. Objective The objective of this study was to compare an anterior cervical discectomy and interbody fusion of a novel polylactide/nano-sized β-tricalcium phosphate (PLA/nβ-TCP) bioabsorbable self-retaining cervical fusion cage (BCFC) with an autologous bone graft and polyetheretherketone (PEEK) cages. Background Although PLA cervical cages have potential advantages compared with traditional materials, they are not currently routinely used in spine surgery because of undesirable effects such as the lack of osteoconductivity and osteolysis around the implant. This study involved the manufacturing of a bioabsorbable cage from PLA/nβ-TCP that was then used as a device for anterior cervical discectomy and fusion (ACDF) on a goat cervical spine fusion model. Materials and methods Eighteen goats underwent C3/C4 discectomy and were randomly divided into three groups based on the following methods: Group A (n=6), an autologous bone graft; Group B (n=6), PEEK cage filled with an autologous graft; and Group C (n=6), BCFC filled with an autologous iliac bone. Radiography was performed preoperatively and postoperatively and at 1, 4, 8, and 12 weeks after the operation. Disc space height (DSH) was measured at the same time. After 12 weeks, the fused segments were harvested and evaluated with functional radiographic views, biomechanical testing, and histological analyses. Results Over a 12-week period, the BCFC and PEEK cage groups exhibited significantly higher DSH values than the bone graft group. Additionally, the BCFC group yielded a significantly lower range of motion in axial rotation than both the autologous bone graft and PEEK cage groups. A histologic evaluation revealed an increased intervertebral bone volume/total volume ratio and better interbody fusion in the BCFC group than in the other groups. Conclusion The BCFC device exhibited better results than the autologous bone graft and PEEK cages in single-level ACDF models in vivo. This device may be a potential alternative to the current PEEK cages.

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Section: Discussionmentioning

confidence: 99%

Bioabsorbable self-retaining PLA/nano-sized β-TCP cervical spine interbody fusion cage in goat models: an in vivo study

Cao¹,

Chen²,

Jiang³

et al. 2017

IJN

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“…The results of this FE analysis imply that the addition of titanium ACP to the caged segments has increased the stability of the targeted segments, which in turn would promise a high rate of successful fusion. Clinical studies showed that the supplementation of ACP after discectomy and cage implantation increased the spinal fusion and decreased symptomatic morbidity, and thus further proved the above conclusion (Majd et al 1999;Samandouras et al 2001;Thalgott et al 2003;Sevki et al 2004;Soderlund et al 2004). However, the optimal stability of the spine construct for a successful solid fusion is still not known.…”

Section: Resultssupporting

confidence: 56%

“…Higher fusion rate, excellent clinical outcome, lower complication occurrence and shorter hospital stay have been achieved with this technique. (Matge 1998;Majd et al 1999;Samandouras et al 2001;Matge 2002;Thalgott et al 2003;Sevki et al 2004;Soderlund et al 2004).…”

Section: Chaptermentioning

confidence: 99%

Optimization and biomechanical analysis of cervical ring cage using finite element method

Yang¹

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Upon the completion of writing this thesis, I would like to express my appreciation to my supervisors, colleagues and family for the guidance, support and love they have given me during these past years. I would offer special thanks to my supervisor A/P Teo Ee Chon and cosupervisor A/P Fuss Franz Konstantin for giving me the great opportunity to conduct a meaningful project bridging the gap between engineering and medicine, for providing me academic guidance and dedicated commitment throughout the course of my research, and for their constructive advice and continuous encouragement that make this thesis possible.

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“…4 The anterior cervical discectomy is considered the procedure of choice for the treatment of segmental degenerative disease of the cervical spine without spinal canal stenosis. 7 The advantages of cage placement have been reported to be restoration and maintenance of the disc height, increased fusion rate, prevention of subsidence, and restoration of lordosis. 21 There is no doubt that anterior discectomy with interbody fusion removes the source of compression and immediately relieves pain in most patients.…”

Section: Discussionmentioning

confidence: 99%

“…1 Currently, different types of fixation systems are available for use in the treatment of cervical disc pathologies. 7 Demonstration of the effects of intervertebral cage placement on intervertebral height and foraminal area may aid in understanding its clinical usefulness. Another advantage, in comparison with autografting, is that there is no need for bone harvesting from the iliac crest.…”

mentioning

confidence: 99%

Efficacy of Anterior Cervical Discectomy and Fusion on Adjacent Disc Height

Lotfinia

Sayyahmelli

Gavam

2011

Neurosurgery Quarterly

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Aim: Disc height has been described as indicator of disc degeneration and regeneration. This study reviews a single surgeon's series of anterior cervical discectomy and interbody cage implantation. The aim of this study was to examine the disc height of the adjacent segment before surgery and at follow-up and to determine the influence on clinical outcome. Methods and Materials:Lateral radiographs were used to evaluate postoperative intervertebral height. The disc height was measured with a ruler. Only 1 cranial adjacent segment was studied. On each radiograph, the posterior height of the body and the height of the operated disc space were measured. The ratio between these 2 measurements was taken.Results: The preoperative posterior height of the body to the height of the adjacent disc space ratio was 0.31 ± 0.11, which postoperatively decreases to 0.30 ± 0.008. The difference from preoperative to postoperative adjacent disc height was statistically significant (P = 0.000).Conclusion: A longer period of evaluation is needed, to see if all these radiographic changes will translate to symptomatic adjacentlevel disease.

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Radiolucent cage for cervical vertebral reconstruction: A prospective study of 17 cases with 2-year minimum follow-up

Cited by 12 publications

References 25 publications

Bioabsorbable self-retaining PLA/nano-sized β-TCP cervical spine interbody fusion cage in goat models: an in vivo study

Bioabsorbable self-retaining PLA/nano-sized β-TCP cervical spine interbody fusion cage in goat models: an in vivo study

Optimization and biomechanical analysis of cervical ring cage using finite element method

Efficacy of Anterior Cervical Discectomy and Fusion on Adjacent Disc Height

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Radiolucent cage for cervical vertebral reconstruction: A prospective study of 17 cases with 2-year minimum follow-up

Cited by 12 publications

References 25 publications

Bioabsorbable self-retaining PLA/nano-sized &beta;-TCP cervical spine interbody fusion cage in goat models: an in vivo study

Bioabsorbable self-retaining PLA/nano-sized &beta;-TCP cervical spine interbody fusion cage in goat models: an in vivo study

Optimization and biomechanical analysis of cervical ring cage using finite element method

Efficacy of Anterior Cervical Discectomy and Fusion on Adjacent Disc Height

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Bioabsorbable self-retaining PLA/nano-sized β-TCP cervical spine interbody fusion cage in goat models: an in vivo study

Bioabsorbable self-retaining PLA/nano-sized β-TCP cervical spine interbody fusion cage in goat models: an in vivo study