Radiology–Pathology Conference: incidental posterior mediastinal ganglioneuroma

Yam, Benjamin; Walczyk, Katherine; Mohanty, Sambit K.; Coren, Charles; Katz, Douglas S.

doi:10.1016/j.clinimag.2009.03.009

Cited by 12 publications

(14 citation statements)

References 20 publications

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“…6 The tail-like extension represents an extension of neoplasm to the adjacent extrapleural fat tissue and mimics a short tail of a dog. with 26, 7, and 3 years of clinical experience, respectively).…”

Section: Methodsmentioning

confidence: 99%

Computed Tomography and Magnetic Resonance Imaging Features of Posterior Mediastinal Ganglioneuroma

Kato

Hara

Ozawa

et al. 2012

Journal of Thoracic Imaging

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Section: Methodsmentioning

confidence: 99%

Computed Tomography and Magnetic Resonance Imaging Features of Posterior Mediastinal Ganglioneuroma

Kato

Hara

Ozawa

et al. 2012

Journal of Thoracic Imaging

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“…There are also some case reports describing GN in the spinal canal, trigeminal nerve, and jugular foramen [5–8]. GN most often manifest as an asymptomatic mass and are found incidentally [3,9,10]. It has also been reported that adrenal GN can secrete dopamine, vasoactive intestinal peptide, and cortisol, leading to hypertensive crisis, diarrhea, and male-like metabolic disorders in women [11–114].…”

Section: Introductionmentioning

confidence: 99%

Imaging Analysis of Ganglioneuroma and Quantitative Analysis of Paraspinal Ganglioneuroma

et al. 2019

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Background This study evaluated the imaging features of ganglioneuroma (GN) and assessed the diagnostic value of the enhancement rate (ER) of CT for GN. Material/Methods We retrospectively reviewed records of 49 patients with histopathologically confirmed GN who underwent preoperative contrast-enhanced CT or MRI between 2010 and 2018. The independent samples t test and chi-square test were used. Receiver operating characteristic (ROC) curves were generated to analyze the diagnostic sensitivity (SE) and specificity (SP). Positive predictive value (PPV) and negative predictive value (NPV) were calculated. Results The CT values were 32.59±3.61 Hounsfield units (HU) for plain scans, 38.87±5.09 HU for the arterial phase, and 54.26±8.14 HU for the venous phase, and the incidence of calcification and cysts was 32.6% and 10.2%, respectively. There was no significant difference in CT results and clinical parameters between mediastinal ganglioneuroma (MGN) and retroperitoneal ganglioneuroma (RGN) ( p >0.05). The area under the curves (AUCs) for the arterial enhancement rate (AER), venous enhancement rate (VER), and AER/VER combined index in diagnosing GN were 0.735, 0.980, and 0.990, respectively. The VER of 0.2819 exhibited the SE and SP at 92.9% and 92.9%, respectively, to characterize the GN, whereas the AER of 0.1779 had SE and SP of 52.4% and 90.5%, respectively. The SE and SP for the combined index were 88.1% and 100%, respectively. The GN showed hypointensity on T1WI, hyperintense, or slightly high signal on T2WI with the linear hypointensity, and hyperintense on DWI. Conclusions A hypodense mass was observed for GN on plain scan and presented delayed enhancement on contrast enhancement. VER or AER/VER combination is more accurate than AER for the diagnosis of paravertebral GN.

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“…The Schwannian stroma is identified by its elongated uniform nuclei and ill-defined cytoplasm [8] . Ganglioneuroma has no immature elements (neuroblasts), atypia, mitotic figures, intermediate cells, or necrosis; and the presence of these features precludes ganglioneuroma [6] , [7] , [9] , [11] .…”

Section: Discussionmentioning

confidence: 99%

“…Other less common locations include visceral ganglia, parapharyngeal region, cranial nerve ganglia, retropharyngeal region, or adrenal medulla [ 2 , 4 , 5 ]. Involvement of the central nervous system has been reported but it is rare [9] , [11] . Ganglioneuroma is often seen in older children or adults, however, it can occur in all age groups with no difference in distribution between males and females [ 3 , 7 , 9 ].…”

Section: Discussionmentioning

confidence: 99%