Radiology and imaging for cavernous malformations

Wang, Kevin Y.; Idowu, Oluwatoyin R.; Lin, Doris

doi:10.1016/b978-0-444-63640-9.00024-2

Cited by 42 publications

(26 citation statements)

References 74 publications

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“…MRI sequences with highest sensitivity to hemosiderin susceptibility effect are more accurate in depicting hemosiderin deposits in the lesions. The most used ones are gradient-echo imaging (GE) and susceptibility-weighted imaging (SWI) sequences [4] .…”

Section: Discussionmentioning

confidence: 99%

“…In addition, radiation-based treatments may also induce vascular malformations such as radiation-induced Cavernous malformations (RICM) and capillary telangiectasias. Cavernous malformations are low-flow vascular malformations, characterized by the lack of mural elements of mature vascular structures and intervening parenchymal neural tissue [4] . Radiation induced capillary telangiectasias (RIT), thin-walled ectatic capillaries with intervening normal brain parenchyma, usually occur 3–9 months after irradiation.…”

Section: Introductionmentioning

confidence: 99%

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Radiation-induced vascular malformations in the brain, mimicking tumor in MRI-based treatment response assessment maps (TRAMs)

Guez

Daniels

Sharabi

et al. 2019

Clinical and Translational Radiation Oncology

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Radiation-induced vascular malformations in the brain, mimicking tumor in MRI-based treatment response assessment maps (TRAMs)

Guez

Daniels

Sharabi

et al. 2019

Clinical and Translational Radiation Oncology

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“…MRI has a high specificity and sensitivity for CCMs, which can be clearly diagnosed and characterized due to their nodular or circular appearance. There is generally no edema or placeholder effect around the lesion except when it is accompanied by bleeding (69). The mechanism of CCM-induced epilepsy is still not fully understood.…”

Section: Discussionmentioning

confidence: 99%

Treatment of Cerebral Cavernous Malformations Presenting With Seizures: A Systematic Review and Meta-Analysis

et al. 2020

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Background: Cerebral cavernous malformations (CCMs) presenting with seizures can be treated with neurosurgery or radiosurgery, but the ideal treatment remains unclear. Currently, there is no adequate randomized controlled trial comparing surgical treatment and radiotherapy for epileptogenic CCMs. Therefore, we conducted a systematic review and meta-analysis of available data from published literature to compare the efficacy and safety of neurosurgery and radiosurgery for epileptogenic CCMs. Methods: We performed a comprehensive search of the Ovid MEDLINE, Web of Science, PubMed, China Biological Medicine and China National Knowledge Infrastructure databases for studies published between January 1994 and October 2019. The search terms were as follows: "epilepsy," "seizures," "brain cavernous hemangioma," "cerebral cavernous malformation," "cerebral cavernous hemangioma," "hemangioma, cavernous, central nervous system." Two researchers independently extracted the data and reviewed all the articles. We compared the advantages and disadvantages of the two treatments. Results: A total of 45 studies were included in our analysis. Overall, the seizure control rate was 79% (95% CI: 75-83%) for neurosurgery and 49% (95% CI: 38-59%) for radiosurgery. In the neurosurgery studies, 4.4% of patients experienced permanent morbidity, while no patients in the radiotherapy studies had permanent morbidity. In addition, the results of subgroup analysis showed that ethnicity, CCMs location and average lesion number are likely significant factors influencing the seizure outcome following treatment. Conclusions: The epilepsy control rate after neurosurgery was higher than that after radiosurgery, but neurosurgery also had a relatively higher rate of permanent morbidity.

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“…We believe that the unique points of the present case are the imaging findings and the clinical course of epilepsy. Preoperatively, we initially considered the lesion as oligodendroglioma [61], ganglioglioma [61] or cavernous malformation [62]. That was because these are known to be calcified and cause seizures [63] [64].…”

Section: Discussionmentioning

confidence: 99%

Surgically treated intracranial supratentorial calcifying pseudoneoplasms of the neuraxis (CAPNON) with drug-resistant left temporal lobe epilepsy: A case report and review of the literature

Tanoue

Uda

Nakajo

et al. 2019

Epilepsy & Behavior Case Reports

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Calcifying pseudoneoplasms of the neuraxis (CAPNON) are rare pathological lesions that can present anywhere in the central nervous system. Symptoms vary depending on the location, though they often include seizures, especially in intracranial and supratentorial lesions. A case of intracranial supratentorial CAPNON presenting with drug-resistant left temporal lobe epilepsy is reported. The patient had a history of drug-resistant focal seizures for over 36 years. The lesion was located in the left mesial temporal lobe, but hippocampal sclerosis and hippocampal invasion were not apparent. The lesion was removed without hippocampectomy, and the patient has been seizure-free for one year.

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Radiology and imaging for cavernous malformations

Cited by 42 publications

References 74 publications

Radiation-induced vascular malformations in the brain, mimicking tumor in MRI-based treatment response assessment maps (TRAMs)

Radiation-induced vascular malformations in the brain, mimicking tumor in MRI-based treatment response assessment maps (TRAMs)

Treatment of Cerebral Cavernous Malformations Presenting With Seizures: A Systematic Review and Meta-Analysis

Surgically treated intracranial supratentorial calcifying pseudoneoplasms of the neuraxis (CAPNON) with drug-resistant left temporal lobe epilepsy: A case report and review of the literature

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