Radiology and biomarkers in assessing disease activity in Takayasu arteritis

Sun, Ying; Huang, Qingrong; Jiang, Lindi

doi:10.1111/1756-185x.13286

Cited by 13 publications

(13 citation statements)

References 56 publications

(67 reference statements)

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“…Type V and type IV are unequivocally the most frequently reported angiographic involvement patterns in previously published studies regarding childhood‐onset Takayasu arteritis . Similar to other case series, in our study the most common type of involvement pattern was type IV followed by type V with respect to Numano's angiographic classification.…”

Section: Discussionsupporting

confidence: 88%

“…Childhood‐onset Takayasu arteritis is reported to be a more refractory disease with lower rates of remissions compared to adult counterparts . Assessment of disease activity and treatment response is still the most difficult challenge for clinicians . There are limited data on clinical features, assessment of disease activity and long‐term outcome of Takayasu arteritis in children.…”

Section: Introductionmentioning

confidence: 99%

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Childhood‐onset Takayasu arteritis: A 15‐year experience from a tertiary referral center

et al. 2018

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Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Childhood‐onset Takayasu arteritis: A 15‐year experience from a tertiary referral center

et al. 2018

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“…Longitudinal analysis demonstrated that a significant increase in sIL-6R levels was only apparent at baseline (47). Consequently, sIL-6R is suggested to mirror disease activity in TA (48). Additional research on cytokines and chemokines in TA showed that serum/plasma levels of IL-8, and chemokine (C-C motif) ligands (CCL) 2 and (CCL) 5, cytokines which guide immune cells to the site of inflammation by means of chemotaxis, were increased in TA patients in comparison with healthy controls, and were also elevated when comparing individuals with active TA to those in remission.…”

Section: Large Vessel Vasculitismentioning

confidence: 99%

“…The concentration of PTX-3 but not that of CRP was, according to Tombetti et al, significantly increased in TA patients who suffered from worsening arterial lesions detected by conventional and computed tomography (CT) angiography. Consequently, plasma PTX-3 levels could serve as a surrogate parameter of disease activity in arteries (48, 52, 54, 55). The reasons for an increase in PTX-3 in TA are similar to those mentioned in the context of GCA.…”

Section: Large Vessel Vasculitismentioning

confidence: 99%

Biomarkers in Vasculitides of the Nervous System

et al. 2019

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Besides being affected by the rare and severe primary angiitis of the central nervous system (PACNS) the nervous system is also affected by primary systemic vasculitides (PSV). In contrast to PACNS, PSV affect not only the central but also the peripheral nervous system, resulting in a large array of potential symptoms. Given the high burden of disease, difficulties in distinguishing between differential diagnoses, and incomplete pathophysiological insights, there is an urgent need for additional precise diagnostic tools to enable an earlier diagnosis and initiation of effective treatments. Methods available to date, such as inflammatory markers, antibodies, cerebrospinal fluid (CSF) analysis, imaging, and biopsy, turn out to be insufficient to meet all current challenges. We highlight the use of biomarkers as an approach to extend current knowledge and, ultimately, improve patient management. Biomarkers are considered to be useful for disease diagnosis and monitoring, for predicting response to treatment, and for prognosis in clinical practice, as well as for establishing outcome parameters in clinical trials. In this article, we review the recent literature on biomarkers which have been applied in the context of different types of nervous system vasculitides including PACNS, giant-cell arteritis, Takayasu's arteritis, polyarteritis nodosa, ANCA (anti-neutrophil cytoplasm antibody)-associated vasculitides, cryoglobulinemic vasculitis, IgA vasculitis, and Behçet's disease. Overall, the majority of biomarkers is not specific for vasculitides of the nervous system.

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“…However, the geographical differences, association with different major histocompatibility complex classes and differential treatment responses to same biological agents suggest that these may not be same. Then there is a detailed write‐up by Jiang's group on the role of radiology and biomarkers in assessing disease activity in TAK . The precise assessment of TAK disease activity has been a challenge in clinical practice.…”

mentioning

confidence: 99%

Vasculitis research: Moving east

Sharma

2019

Int J of Rheum Dis

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It gives me immense pleasure to present this special issue of the International Journal of Rheumatic Diseases on "Vasculitis." I thank the editor-in-chief Professor Danda for asking me to be the guest editor with a brief that this issue should give an overview of the recent advances in various vasculitic disorders from all over the world, with a focus on contributions from the APLAR region. The topics for this supplement have been chosen keeping in mind their relevance both to avid researchers in the field and practicing rheumatologists. The supplement starts with a tribute to Professor Paul Bacon, whom unfortunately we recently lost. He was a stalwart of the field, a champion of collaborative research and was a great support to the Indian Rheumatology Association vasculitis (IRAVAS) research group. He was the guiding force behind the development and validation of Indian Takayasu Clinical Activity Score (ITAS2010). 1 There have been significant advancements in the field of various vasculitides in recent times. The first write-up by Durga et al is on current trends and future directions in vasculitis research. 2 This is an exhaustive review, which summarizes the research published in the field of large vessel vasculitis (LVV), and antineutrophil cytoplasmic antibody-associated vasculitis (AAV) in the last 3 years and also details the studies that are in the pipeline and would be looked up to in the coming years. The write-up ends with a perspective of vasculitis research from a viewpoint of developing countries and resource-poor settings. There have been significant developments in nomenclature and classification of various vasculitic disorders. The draft classification criteria of AAV, which are an outcome of the data-driven multi-center Diagnostic and Classification Criteria for Vasculitis study (DCVAS), were presented at the American College of Rheumatology 2017 meeting in San Diego, USA in November, 2017. The next write-up is by Richard Watts on evolving concepts in classification of systemic vasculitis, the stage at which the various new criteria are and what is the way forward?. 3 The next section is on LVV. The first write-up by Tanaz Kermani discusses the similarities and differences in giant cell arteritis (GCA) and Takayasu arteritis (TAK) and whether they are a spectrum of the same disease. 4 The shared clinical, histopathologic and radiographic features of GCA and TAK suggest that the two conditions may be a spectrum of the same disease. However, the geographical differences, association with different major histocompatibility complex classes and differential treatment responses to same biological agents suggest that these may not be same. Then there is a detailed write-up by Jiang's group on the role of radiology and biomarkers in assessing disease activity in TAK. 5 The precise assessment of TAK disease activity has been a challenge in clinical practice. The role of positron emission tomography/computed tomography, magnetic resonance imaging, CT angiography and contrast ultrasound in assessing diseas...

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Radiology and biomarkers in assessing disease activity in Takayasu arteritis

Cited by 13 publications

References 56 publications

Childhood‐onset Takayasu arteritis: A 15‐year experience from a tertiary referral center

Childhood‐onset Takayasu arteritis: A 15‐year experience from a tertiary referral center

Biomarkers in Vasculitides of the Nervous System

Vasculitis research: Moving east

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