Radiologically isolated syndrome

Lebrun-Frenay, Christine; Kantarci, Orhun; Siva, Aksel; Azevedo, Christina J; Makhani, Naila; Pelletier, Daniel; Okuda, Darin T

doi:10.1016/s1474-4422(23)00281-8

Cited by 9 publications

(2 citation statements)

References 88 publications

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“…Not all individuals with RIS will evolve to experience a first neurological symptom. 17,27,32,33 This is exemplified further by numerous post-mortem investigations revealing signs of incidental histopathological demyelination. 32 In addition, countervailing factors, including misclassifying MRI lesions as having an origin related to CNS demyelination, are palpable risks.…”

Section: Therapeutic Trials In Rismentioning

confidence: 84%

“…Despite the absence of established guidelines for medical work-up, clinical follow-up, and MRI surveillance, recent proposed guidance involved obtaining baseline cervical and thoracic imaging in the presence of an abnormal brain MRI study along with annual clinic and imaging surveillance. 17 Continued exploration for alternate explanations for the incidentally identified abnormal MRI findings should also persist.…”

Section: Rismentioning

confidence: 99%

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Radiologically isolated syndrome in the spectrum of multiple sclerosis

Okuda,

Lebrun-Frénay

2024

Mult Scler

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The radiologically isolated syndrome (RIS) currently represents the earliest detectable preclinical phase of multiple sclerosis (MS). Remarkable advancements have been recently made, including the identification of risk factors for disease evolution, revisions to the existing 2009 RIS criteria, and our understanding of the impact of early disease-modifying therapy use in the prevention/delay of symptomatic MS from two randomized clinical trials. Here, we discuss RIS in the context of the spectrum of MS, implications in the clinical management of individuals, and provide insights into future opportunities and challenges given the anticipated inclusion of asymptomatic MS in the formal definition of MS.

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