Radiological pulmonary findings after breast cancer irradiation: A prospective study

Järvenpää, Ritva; Holli, Kaija; Pitkänen, Maunu; Hyödynmaa, Simo; Rajala, Juha; Lahtela, Sirpa-Liisa; Ojala, A

doi:10.1080/02841860500334921

Cited by 30 publications

(19 citation statements)

References 31 publications

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“…Besides, no significant correlation between pulmonary function and total radiation dose was found, which is in accordance with the profile of the studied patient 23 . Imaging tests can also be useful 5,6,12 , because at an acute phase, radiation can lead to the appearance of attenuation or consolidation areas in lung x-rays, while at a late stage, bronchiectasis areas and loss of volume can be observed 10,12 . However, it was not possible to demonstrate radiological changes in this study, because only tests of pulmonary function and fatigue assessment were conducted.…”

Section: Discussionmentioning

confidence: 99%

“…RT: radiotherapy; FACT-F: Functional Assessment of Cancer Therapy Fatigue; FVC: forced vital capacity; FEV1: forced expiratory volume; PEF: peak expiratory flow; EPmax: maximal expiratory pressure; IPmax: maximal inspiratory pressure; r: Spearman's correlation with longer follow-up and higher number of reassessments after RT 4,5,[23][24][25] . Ooi et al 24 , in a prospective study performed 1, 3, 6 and 12 months after the conclusion of RT, showed that RT can be associated with an irreversible reduction of FCV, FEV1 and the carbon monoxide diffusing capacity.…”

Section: Discussionmentioning

confidence: 99%

“…Despite the evolution in diagnosis and treatment, the surgical procedures and complementary therapies, such as radiotherapy, chemotherapy and hormone therapy are still prevalent [2][3][4] . Radiotherapy (RT) is capable of destroying tumor cells, reducing the risk of local recurrence and increasing survival rates 5,6 . The most common application technique is the external RT (teletherapy), in which ionizing radiation goes through different tissues before reaching the tumor area; therefore, organs and normal tissues are subjected to the toxic effects of the emitted rays 7 .…”

Section: Introductionmentioning

confidence: 99%

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Efeito da radioterapia na função pulmonar e na fadiga de mulheres em tratamento para o câncer de mama

Santos¹,

Rett²,

Mendonça³

et al. 2013

Fisioter. Pesqui.

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O presente estudo comparou a função pulmonar e a fadiga de mulheres antes e após a radioterapia (RT) adjuvante para tratamento do câncer de mama, e correlacionou a função pulmonar com a dose de radiação e fadiga. Foi conduzido um estudo observacional longitudinal envolvendo 20 mulheres. A função pulmonar foi avaliada pela espirometria (ClementClarke®) e manovacuometria (GlobalMed®, modelo MVD 300), e a fadiga pelo Functional Assessment of Cancer Therapy Fatigue (FACT-F). Todas as avaliações foram realizadas antes da primeira sessão e uma semana após o término da RT adjuvante. Para a análise estatística foram utilizados os testes Wilcoxon Signed Rank Test e correlação de Spearman, adotando-se nível de significância p<0,05. Na espirometria, encontrou-se redução significativa da capacidade vital forçada (23,52%), do volume expiratório forçado no primeiro segundo (26,23%) e do pico de fluxo expiratório (10,12%) (p=0,001). As pressões expiratórias e inspiratórias máximas também diminuíram significativamente (25,45 e 32,92%, respectivamente). Observou-se diminuição significativa do bem-estar físico e do bem-estar funcional, e um aumento significativo da fadiga no FACT-F (p=0,001). Não foram observadas correlações entre as variáveis da função pulmonar com a dose de radiação e fadiga. Em curto prazo, a RT promoveu redução na função pulmonar, mas a mesma permaneceu próxima à normalidade para a amostra estudada. Observou-se aumento significativo da fadiga e diminuição dos escores dos domínios bem-estar físico e funcional.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Efeito da radioterapia na função pulmonar e na fadiga de mulheres em tratamento para o câncer de mama

Santos¹,

Rett²,

Mendonça³

et al. 2013

Fisioter. Pesqui.

View full text Add to dashboard Cite

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“…4,8 Chest x-ray may be normal in 80% of patients. 10 As part of the treatment for breast cancer, radiation therapy has been shown to lead to CEP, especially in those who have underlying allergies such as asthma or atopic manifestations. 1,11 Usually the areas that are irradiated are the ones that may develop CEP.…”

Section: Case Reportmentioning

confidence: 99%

“…1 High-resolution CT is highly sensitive in the detection of lung injury post-radiation. 10 Radiation therapy may predispose for CEP; however, a trigger such as an environmental exposure, drugs, and Aspergillus is usually needed. 1 The proposed mechanism is priming followed by an antigenic stimulation.…”

Section: Case Reportmentioning

confidence: 99%

Chronic Eosinophilic Pneumonia in a Breast Cancer Patient Post-Radiation Therapy: A Case Report

Chaaban

Salloum

2013

Respir Care

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Occurrence of pneumonitis following radiotherapy of breast cancer – A prospective study

et al. 2018

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Aimof this study is to determine the temporal resolution of therapy-induced pneumonitis, and to assess promoting factors in adjuvant treated patients with unilateral mammacarcinoma.Patients and methodsA total of 100 post-surgery patients were recruited. The cohort was treated by 2 field radiotherapy (2FRT; breast and chest wall, N = 75), 3 field radiotherapy (3FRT; + supraclavicular lymphatic region, N = 8), or with 4 field radiotherapy (4FRT; + parasternal lymphatic region, N = 17). Ninety-one patients received various systemic treatments prior to irradiation. Following an initial screening visit post-RT, two additional visits after 12 and 25 weeks were conducted including radiographic examination. In addition, general anamnesis and the co-medication were recorded. The endpoint was reached as soon as a pneumonitis was developed or at maximum of six months post-treatment.ResultsA pneumonitis incidence of 13% was determined. Of 91 patients with prior systemic therapy, 11 patients developed pneumonitis. Smoking history and chronic obstructive pulmonary disease (COPD) appeared to be positive predictors, whereas past pneumonia clearly promoted pneumonitis. Further pneumonitis-promoting predictors are represented by the applied field extensions (2 field radiotherapy [2FRT] < 3 field radiotherapy [3FRT] < 4 field radiotherapy [4FRT]) and the type of combined initial systemic therapies. As a consequence, all of the three patients in the study cohort treated with 4FRT and initial chemotherapy combined with anti-hormone and antibody protocols developed pneumonitis. A combination of the hormone antagonists tamoxifen and goserelin might enhance the risk for pneumonitis. Remarkably, none of the 11 patients co-medicated with statins suffered from pneumonitis.ConclusionsThe rapidly increasing use of novel systemic therapy schedules combined with radiotherapy (RT) needs more prospective studies with larger cohorts. Our results indicate that contribution to pneumonitis occurrence of various (neo)adjuvant therapy approaches followed by RT is of minor relevance, whereas mean total lung doses of >10 Gy escalate the risk of lung tissue complications. The validity of potential inhibitors of therapy-induced pneumonitis as observed for statin co-medication should further be investigated in future trials.

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Radiological pulmonary findings after breast cancer irradiation: A prospective study

Cited by 30 publications

References 31 publications

Efeito da radioterapia na função pulmonar e na fadiga de mulheres em tratamento para o câncer de mama

Efeito da radioterapia na função pulmonar e na fadiga de mulheres em tratamento para o câncer de mama

Chronic Eosinophilic Pneumonia in a Breast Cancer Patient Post-Radiation Therapy: A Case Report

Occurrence of pneumonitis following radiotherapy of breast cancer – A prospective study

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