Radiological-pathological correlation of pleomorphic liposarcoma of the anterior mediastinum in a 17-year-old girl

Saeed, Maysa; Plett, Sara; Kim, Grace; Daldrup-Link, Heike E.; Courtier, Jesse

doi:10.1007/s00247-010-1797-1

Cited by 15 publications

(5 citation statements)

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“…However, some cases have been reported in younger patients, and the youngest recorded was 8 years old. [ 5 – 7 ] In our study, there were 4 men and 2 women, and the mean age was 65.40 ± 13.48 years (range, 46–82 years).…”

Section: Discussionmentioning

confidence: 81%

Pleomorphic liposarcoma

et al. 2018

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Rationale:Pleomorphic liposarcoma (PLS), is a rare subtype of liposarcoma, and is considered to be of the highest malignancy grade.Patient concerns:We aimed to analyze the clinical features, diagnosis, treatment, and recurrence of the 6 cases of PLS.Diagnoses:Six cases with confirmed pathological PLS presented at out hospital from January 2003 to January 2017. The postoperative pathology of 5 cases confirmed PLS, and the other was confirmed as PLS with well-differentiated liposarcoma.Interventions:All 6 patients underwent complete tumor resection at the time of the first definite diagnosis, and one of them had underwent 3 cycles of chemotherapy treatment.Outcomes:There were 4 cases with local recurrence and surgery was repeated after the first radical excision. One case was not recurrent after 27 months post-operation, and the other was lost. The shortest recurrence time of all of these cases was 4 months, and the longest was 29 months after the first radical surgery.Lessons:PLS is a rare and high-grade malignancy with high recurrence, poor prognosis, and its treatment is still highly controversial. More studies are required to determine the appropriate treatment and therapeutic strategies to improve the survival rate of patients with PLS, as the disease is associated with frequent relapse.

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Section: Discussionmentioning

confidence: 81%

Pleomorphic liposarcoma

et al. 2018

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“…The histological types are correlated with the potential for metastasis, this subtype being the least aggressive and the pleomorphic one having the worst prognosis. 4,8 Depending on the degree of differentiation, in the tomography, a mass of fatty tissue with a variable soft tissue component may be evidenced, however these characteristics are not sufficient for diagnosis and a histological study is always required. Various techniques have been used for biopsy of mediastinal masses, ultrasound or tomographyguided biopsy, mediastinoscopy, mediastinotomy and open surgery.…”

Section: Discussionmentioning

confidence: 99%

Liposarcoma mediastinal en una adolescente

Molina-Valencia¹,

Romero-Espitia²,

Loockhart³

2022

NCT Neumología Y Cirugía De Tórax

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Sarcomas of the mediastinum are rare. The incidence in pediatric age is unknown. Its symptoms are caused by the compression of structures in the mediastinum. We present a case of a 15-year-old adolescent, she had dyspnea and chest pain, an anterior mediastinal mass was identified, in imaging studies the mass had various areas of soft tissue density and fatty tissue with histology reporting liposarcoma. She was managed with surgical resection and postoperative radiotherapy. Less than 25 cases have been reported in children under 18 years of age, surgical management is the mainstay in treatment and the prognosis is given by complete resection of the lesion.

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“…Saeed et al [10] performed the surgery on a 17-year-old girl with pleomorphic liposarcoma of the anterior mediastinum, followed by adjuvant chemotherapy with doxorubicin (total dose 375 mg/m2) combined with ifosfomide (total dose 54 mg/m2) and radiation therapy (total dose 55.8 Gy) on the anterior mediastinum. However, reports on adjuvant treatment of liposarcoma are of mostly case reports and clinical trial conclusions, and no clear evidence can prove the exact effect of radiotherapy and chemotherapy in liposarcoma.…”

Section: Discussionmentioning

confidence: 99%

Giant Atypical Lipomatous Tumor of Posterior Mediastinum In Adolescent ：A Case Study and the Literature Review

Zhang

Chen

et al. 2020

Preprint

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Background: It is usually common for liposarcoma as one of the soft tissue sarcomas to be found in adults, and the disease in children is the rare case. Case presentation: This article involves in a 14-year-old boy with a primary posterior mediastinal atypical lipomatous tumor. It also provides a literature review and summary for the disease with the aim of making the disease well learned, because of the absence of the uniform standards for the clinical features, diagnostic methods, best treatment methods, and clinical efficacy of the atypical lipomatous tumor.Conclusion: Complete surgical resection is the best method for the eradication of tumors. However, mediastinal liposarcoma can not be completely removed by surgery in some cases. For the treatment of residual tumor tissue, molecular inhibitors will be an important supplementary method for the treatment of liposarcoma in the future.

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Radiological-pathological correlation of pleomorphic liposarcoma of the anterior mediastinum in a 17-year-old girl

Cited by 15 publications

References 5 publications

Pleomorphic liposarcoma

Pleomorphic liposarcoma

Liposarcoma mediastinal en una adolescente

Giant Atypical Lipomatous Tumor of Posterior Mediastinum In Adolescent ：A Case Study and the Literature Review

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Radiological-pathological correlation of pleomorphic liposarcoma of the anterior mediastinum in a 17-year-old girl

Cited by 15 publications

References 5 publications

Pleomorphic liposarcoma

Pleomorphic liposarcoma

Liposarcoma mediastinal en una adolescente

Giant Atypical Lipomatous Tumor of Posterior Mediastinum In Adolescent ：A Case Study and the Literature Review​

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Giant Atypical Lipomatous Tumor of Posterior Mediastinum In Adolescent ：A Case Study and the Literature Review