Radiological Image Features of the Atypical Teratoid/Rhabdoid Tumor in Adults: A Systematic Review

Kanoto, Masafumi; Toyoguchi, Yuki; Hosoya, Takamitsu; Kuchiki, Megumi; Sugai, Yukio

doi:10.1007/s00062-013-0282-2

Cited by 27 publications

(25 citation statements)

References 34 publications

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“…Of note, our study and Torchia's series both focus on paediatric AT/RT, while a few AT/RT adult cases are reported 37 , challenging the proposed hypotheses of early embryonic progenitors as exclusive cells of origin. One explanation could be that a pool of embryonic neuron stem cells remains until adulthood.…”

Section: Discussioncontrasting

confidence: 60%

The occurrence of intracranial rhabdoid tumours in mice depends on temporal control of Smarcb1 inactivation

et al. 2016

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Rhabdoid tumours (RTs) are highly aggressive tumours of infancy, frequently localized in the central nervous system (CNS) where they are termed atypical teratoid/rhabdoid tumours (AT/RTs) and characterized by bi-allelic inactivation of the SMARCB1 tumour suppressor gene. In this study, by temporal control of tamoxifen injection in Smarcb1flox/flox;Rosa26-CreERT2 mice, we explore the phenotypes associated with Smarcb1 inactivation at different developmental stages. Injection before E6, at birth or at 2 months of age recapitulates previously described phenotypes including embryonic lethality, hepatic toxicity or development of T-cell lymphomas, respectively. Injection between E6 and E10 leads to high penetrance tumours, mainly intra-cranial, with short delays (median: 3 months). These tumours demonstrate anatomical, morphological and gene expression profiles consistent with those of human AT/RTs. Moreover, intra- and inter-species comparisons of tumours reveal that human and mouse RTs can be split into different entities that may underline the variety of RT cells of origin.

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Section: Discussioncontrasting

confidence: 60%

The occurrence of intracranial rhabdoid tumours in mice depends on temporal control of Smarcb1 inactivation

et al. 2016

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“…Radiological findings from our case report were similar to those previously reported in adult AT/RT [5,9]. In our case, the tumour was hyperattenuated with cystic/necrotic components seen on CT.…”

Section: Discussionsupporting

confidence: 89%

“…In one case study, cerebral angiography showed tumour stain and early venous filling suggestive of a hypervascular tumour [9]. These radiological findings of a vascular tumour were consistent with our intraoperative findings.…”

Section: A C Bsupporting

confidence: 85%

“…In our case, the tumour was hyperattenuated with cystic/necrotic components seen on CT. These features are seen in 91% of the cases of adult AT/ RT [9]. In a study by Kanoto et al, they reported 80% were hypointense on T1-weighted imaging, 72% were mixed-intensity on T2-weighted imaging, 100% had restricted diffusion, 70% had heterogeneous enhancement, 56% had cyst/necrosis, 42% had hemorrhage and 33% had calcifications [9].…”

Section: Discussionmentioning

confidence: 98%

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Intraventricular atypical teratoid rhabdoid tumour in an adult: a case report and literature review

Chan

Marro

Chainey

et al. 2019

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We report a case of atypical teratoid/rhabdoid tumour (AT/RT) in an adult patient in the deep grey matter with extension into the lateral ventricle. To our knowledge, this is the first example of AT/RT involving the lateral ventricle in an adult. The patient presented with headache and confusion, and subsequently required emergent surgery. His postoperative course was complicated by hemorrhage into the surgical site. The location and vascularity of the tumour affected the extent of resection achieved and likely contributed to postoperative complications. We discuss radiological features of AT/RT in adults and implications for investigations and management.

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“…In addition, the clinical manifestations and neuroimaging characteristics of patients often lacked specificity (19). Although mixed intensity in T2-weighted image, heterogeneous contrast enhancement, mild peritumoral edema, high density, and bone destruction on computed tomography have been reported frequently in adult-onset AT/RT (9,20), there are still great challenges in accurate diagnosis of AT/RT preoperatively. In clinical practice, AT/RT is easily misdiagnosed as other types of intracranial tumor before pathological confirmation.…”

Section: Discussionmentioning

confidence: 99%

Atypical Teratoid/Rhabdoid Tumor Originated From the Trigeminal Nerve in a Young Male Adult: Case Report and Review of the Literature

Chen

Mei

et al. 2020

Front. Neurol.

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Atypical teratoid/rhabdoid tumor (AT/RT) is a highly malignant central nervous system neoplasm predominantly found in children under the age of 3 years, and is extremely rare in adults. There is no specific clinical presentations or radiological features in reported cases of AT/RT. Diagnosis of brain AT/RT is mainly dependent on the classical pathological characteristics. We report a rare case of AT/RT arising from the trigeminal nerve and leading to progressively multiple cranial nerve palsies in a 25-year-old male patient. Microsurgical resection of the tumor has been performed and confirmed the diagnosis by postoperative pathology. To our knowledge, this is the second case of adult-onset AT/RT originating from the trigeminal nerve.

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Radiological Image Features of the Atypical Teratoid/Rhabdoid Tumor in Adults: A Systematic Review

Cited by 27 publications

References 34 publications

The occurrence of intracranial rhabdoid tumours in mice depends on temporal control of Smarcb1 inactivation

The occurrence of intracranial rhabdoid tumours in mice depends on temporal control of Smarcb1 inactivation

Intraventricular atypical teratoid rhabdoid tumour in an adult: a case report and literature review

Atypical Teratoid/Rhabdoid Tumor Originated From the Trigeminal Nerve in a Young Male Adult: Case Report and Review of the Literature

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