Radiological, histological, and hematological evaluation of hydroxyapatite‐coated resorbable magnesium alloy screws placed in rabbit tibia

Lim, Ho-Kyung; Byun, Soo-Hwan; Lee, Jin‐Yong; Lee, Jungwoo; Kim, Sae-Mi; Lee, Sung-Mi; Kim, Hyoun‐Ee; Lee, Jong-Ho

doi:10.1002/jbm.b.33703

Cited by 21 publications

(14 citation statements)

References 36 publications

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“…Lim et al [ 15 ], in 2016, reported that the blood magnesium level was found to be within the normal range when WE43 Mg alloy was inserted on the tibia of rabbits. Zhang et al [ 16 ] ran blood tests after inserting a Mg-Zn-Mn alloy on the femur of rats, and the result showed elevated BUN, serum creatinine, AST, and ALT above the norm.…”

Section: Discussionmentioning

confidence: 99%

Biocompatibility and Biocorrosion of Hydroxyapatite-Coated Magnesium Plate: Animal Experiment

et al. 2017

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Magnesium (Mg) has the advantage of being resorbed in vivo, but its resorption rate is difficult to control. With uncontrolled resorption, Magnesium as a bone fixation material has minimal clinical value. During resorption not only is the strength rapidly weakened, but rapid formation of metabolite also occurs. In order to overcome these disadvantages, hydroxyapatite (HA) surface coating of pure magnesium plate was attempted in this study. Magnesium plates were inserted above the frontal bone of Sprague-Dawley rats in both the control group (Bare-Mg group) and the experimental group (HA-Mg group). The presence of inflammation, infection, hydrogen gas formation, wound dehiscence, and/or plate exposure was observed, blood tests were performed, and the resorption rate and tensile strength of the retrieved metal plates were measured. The HA-Mg group showed no gas formation or plate exposure until week 12. However, the Bare-Mg group showed consistent gas formation and plate exposure beginning in week 2. WBC (White Blood Cell), BUN (Blood Urea Nitrogen), Creatinine, and serum magnesium concentration levels were within normal range in both groups. AST (Aspartate Aminotransferase) and ALT (Alanine Aminotransferase) values, however, were above normal range in some animals of both groups. The HA-Mg group showed statistically significant advantage in resistance to degradation compared to the Bare-Mg group in weeks 2, 4, 6, 8, and 12. Degradation of HA-Mg plates proceeded after week 12. Coating magnesium plates with hydroxyapatite may be a viable method to maintain their strength long enough to allow bony healing and to control the resorption rate during the initial period.

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Section: Discussionmentioning

confidence: 99%

Biocompatibility and Biocorrosion of Hydroxyapatite-Coated Magnesium Plate: Animal Experiment

et al. 2017

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“…Zhang et al 53 reported that blood tests like BUN, serum creatinine, AST, and ALT were elevated than the normal limit after inserting an Mg‐Zn‐Mn alloy in the femur of rats. The normal range of blood magnesium level was found by Lim et al 54 in the study when Mg alloy was inserted in the tibia of rabbits.…”

Section: Discussionmentioning

confidence: 61%

Biocompatibility and biodegradability evaluation of magnesium‐based intramedullary bone implants in avian model

Abhishek

Jaiswal

Dubey

et al. 2020

J Biomedical Materials Res

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At present days osteosynthesis modalities for avian fracture management are inadequate. External coaptation is the most practiced method however, specialized clinics have started introducing intramedullary pinning, external skeletal fixation with tie‐in‐fixation for fracture immobilization. Magnesium (Mg) based biomaterials are trustable developments in the field of orthopedics compared to their permanent stainless steel counterparts concerning long term adverse reaction. Mg implants are becoming promising for their use as intramedullary accessories because they are bioresorbable with high strength‐weight ratio and the similarities in density and elastic modulus to the natural bones. However, their severe biodegradation trait restricts frequent use as load‐bearing orthopedic implants. In this study, the biocompatibility and biodegradability of Mg based intramedullary cylindrical spacers (2.4 mm diameter × 8 mm height) reinforced with 0, 5, 15 wt% of hydroxyapatite (HA, Ca10(PO4)6(OH)2) were evaluated in 18 Uttara‐fowl birds. Clinical, radiological (from immediate postoperative days till 24th week), biochemical (first three postoperative weeks) and histopathological study of test bone were carried out to evaluate implant degradation and osteocompatibility. Biodegradation of Mg‐3Zn/0HA and Mg‐3Zn/15HA initiated a bit earlier at second week of implantation, while that of Mg‐3Zn/5HA at 3‐fourth week, and found biocompatible and biodegradable with no observable clinical and histopathological changes.

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“…be biocompatible with no toxicity as revealed by hema tological test following placement of HA-WE43 screws in rabbit's tibia[4]. The present study' s use of HA-WE43 indicated its benefit in providing a well-controlled degraded conduit without any observable accumulated gas.…”

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confidence: 52%

“…The WE43 fabrication and HA coating were made as described previously by Lim et al [4]. An WE43 In vivo evaluation of HA-WE43 nerve conduit…”

Section: Ha-coated Mg Disks Preparationmentioning

confidence: 99%

Hydroxyapatite coated magnesium alloy for peripheral nerve regeneration

Almansoori

Kim

et al. 2018

Oral Biol Res

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Magnesium (Mg) has been used as a neuroprotective agent and for orthopedic and cardiovascular stent applications for a long time. Mg is a promising material for neural regeneration own to its metallic nature, biodegradability, and biocompatibility. To evaluate the benefit of hydroxyapatite (HA) coated Mg alloy (WE43) nerve conduit in peripheral nerve injury regeneration. In vitro cell adhesion and proliferation of PC12 cells and Schwann cells over pure Mg, WE43, HA coated pure Mg (HA-Mg), and HA coated WE43 (HA-WE43) disks were assessed using scanning electron microscope and EZ-CYTOX assay. In vivo study was also performed for sham, silicone nerve conduits, and HA-WE43 nerve conduits to evaluate rat sciatic nerve regeneration over 10 mm gap. These rats were observed for three months with weekly functional assessment using sciatic functional index. Regeneration was evaluated through retrograde neuron labeling and histomorphometric analysis at the end of the experiment. Non-coated pure Mg and WE43 conduits showed fast resorption rate and high gas formation. Higher adhesion and proliferation of PC12 cells were found in HA-WE43 disks. At the end of three months, HA-WE43 nerve conduit showed mild resorption without detectable gas formation in the surrounding tissue. However, only scanty regenerated neural tissue was found within the conduit. HA-WE43 nerve conduit showed controlled degradation and absence of gas formation with scanty regenerated neural tissue.

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Radiological, histological, and hematological evaluation of hydroxyapatite‐coated resorbable magnesium alloy screws placed in rabbit tibia

Cited by 21 publications

References 36 publications

Biocompatibility and Biocorrosion of Hydroxyapatite-Coated Magnesium Plate: Animal Experiment

Biocompatibility and Biocorrosion of Hydroxyapatite-Coated Magnesium Plate: Animal Experiment

Biocompatibility and biodegradability evaluation of magnesium‐based intramedullary bone implants in avian model

Hydroxyapatite coated magnesium alloy for peripheral nerve regeneration

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