Radiological findings of alveolar hydatid disease of the lung caused by <i>Echinococcus multilocularis</i>

Ohsaki, Yoshinobu; Sasaki, Tatsuya; Shibukawa, Kiyoko; Takahashi, Toru; Osanai, Shinobu

doi:10.1111/j.1440-1843.2007.01055.x

Cited by 10 publications

(4 citation statements)

References 8 publications

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“…1,23,24 Therefore, it is important to accumulate clinical imaging data such as those from CT and ultrasound, which are non-invasive and performed at a relatively early stage of clinical course to arrive at a method to distinguish AE from confusing factors such as malignant tumors, pseudocysts, and pseudomyxomas. Moreover, the differential diagnosis of AE from other parasitic disease is also difficult 25 ; thus, a worldwide database should be created 26 for the differential diagnosis of AE from other parasitic diseases such as fascioliasis, toxocariasis, trichinosis, strongyloidiasis, and cysticercosis. However, the human imaging features of AE have not been fully accumulated.…”

Section: Discussionmentioning

confidence: 99%

Significance of Imaging Features of Alveolar Echinococcosis in Studies on Nonhuman Primates

Kishimoto

Yamada²,

Yamano³

et al. 2009

Am J Trop Med Hyg

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In this study, we report the imaging findings in two Japanese monkeys (Macaca fuscata) diagnosed with alveolar echinococcosis. Both monkeys were treated with albendazole for 10 years, without surgery. Radiography, computed tomography, and contrast-enhanced ultrasonography were performed under general anesthesia. This is the first report on contrast-enhanced ultrasonographic imaging for alveolar echinococcosis wherein perflubutane was used as the contrast medium. The findings of the imaging analyses were similar to those reported for alveolar echinococcosis in humans, such as snowflake sign and worm-eaten sign. In addition, the serology correlated well with the imaging data in these two monkeys. Therefore, we propose that the imaging findings of alveolar echinococcosis in nonhuman primates may be used to accumulate data on this condition in human alveolar echinococcosis.

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Section: Discussionmentioning

confidence: 99%

Significance of Imaging Features of Alveolar Echinococcosis in Studies on Nonhuman Primates

Kishimoto

Yamada²,

Yamano³

et al. 2009

Am J Trop Med Hyg

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“…Pathological diagnosis requires a large bulk of pathological tissue and experienced pathologists. Moreover, histopathological biopsy may fail to detect hydatid tissue for diagnosing the disease, which mainly relies on serology and imaging systems [ 15 ]. Therefore, conventional diagnostic methods make it extremely challenging to detect and diagnose AE in non-endemic areas.…”

Section: Discussionmentioning

confidence: 99%

Rapid diagnosis of alveolar echinococcosis from lung puncture sample using metagenomic next-generation sequencing: a case report

Zhou,

Li,

Deng

et al. 2024

BMC Infect Dis

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Introduction Alveolar echinococcosis (AE), caused by the larval forms of Echinococcus multilocularis, is a zoonotic disease affecting the liver, lungs, lymph nodes, kidneys, brain, bones, thyroid, and other organs. Diagnosing AE in a non-endemic area is usually challenging. With the rapid development and increasing application of sequencing techniques in recent years, metagenomic next-generation sequencing (mNGS) has become a powerful tool for diagnosing rare infectious diseases. Case Presentation A 45-year-old woman was admitted to the hospital for the presence of pulmonary shadows for more than 3 months. The lung computed tomography (CT) at a local hospital revealed scattered solid and quasi-circular nodules in the left upper lobe, left lower lobe, right middle lobe, and right lower lobe. The largest nodule was located in the dorsal part of the right lung, measuring 2.0 × 1.7 × 1.5 cm. Moreover, abdominal CT revealed one space-occupying lesion each in the left and right lobes. The pathological analysis of the lung biopsy specimen revealed infiltration of lymphocytes, plasma cells, and eosinophils in the alveolar wall and interstitial area. No pathogenic bacteria were observed in the sputum smear and culture tests. There were no parasite eggs in the stool. The mNGS of the lung puncture tissue revealed 6156 sequence reads matching E. multilocularis; thus, the condition was diagnosed as AE. Albendazole 400 mg was administered twice daily, and the patient was stable during follow-up. Conclusion This case emphasizes the role of mNGS in diagnosing AE. As a novel, sensitive, and accurate diagnostic method, mNGS could be an attractive approach for facilitating early diagnosis and prompt treatment of infectious diseases, especially when the infection was caused by rare pathogens.

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“…After a long period of latent and asymptomatic stage, HAE can progress into a cirrhotic stage [6], or it can metastasize to other organs (e.g. the lungs and brain) [7–9] and cause local organ-function impairment and metastatic infiltration [10].…”

Section: Introductionmentioning

confidence: 99%

Deciphering the metabolic perturbation in hepatic alveolar echinococcosis: a 1H NMR-based metabolomics study

et al. 2019

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Background Hepatic alveolar echinococcosis (HAE) is caused by the growth of Echinococcus multilocularis larvae in the liver. It is a chronic and potentially lethal parasitic disease. Early stage diagnosis for this disease is currently not available due to its long asymptomatic incubation period. In this study, a proton nuclear magnetic resonance ( 1 H NMR)-based metabolomics approach was applied in conjunction with multivariate statistical analysis to investigate the altered metabolic profiles in blood serum and urine samples obtained from HAE patients. The aim of the study was to identify the metabolic signatures associated with HAE. Results A total of 21 distinct metabolic differences between HAE patients and healthy individuals were identified, and they are associated with perturbations in amino acid metabolism, energy metabolism, glyoxylate and dicarboxylate metabolism. Furthermore, the present results showed that the Fischer ratio, which is the molar ratio of branched-chain amino acids to aromatic amino acids, was significantly lower ( P < 0.001) in the blood serum obtained from the HAE patients than it was in the healthy patient group. Conclusions The altered Fischer ratio, together with perturbations in metabolic pathways identified in the present study, may provide new insights into the mechanistic understanding of HAE pathogenesis and potential therapeutic interventions. Electronic supplementary material The online version of this article (10.1186/s13071-019-3554-0) contains supplementary material, which is available to authorized users.

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Radiological findings of alveolar hydatid disease of the lung caused by Echinococcus multilocularis

Cited by 10 publications

References 8 publications

Significance of Imaging Features of Alveolar Echinococcosis in Studies on Nonhuman Primates

Significance of Imaging Features of Alveolar Echinococcosis in Studies on Nonhuman Primates

Rapid diagnosis of alveolar echinococcosis from lung puncture sample using metagenomic next-generation sequencing: a case report

Deciphering the metabolic perturbation in hepatic alveolar echinococcosis: a 1H NMR-based metabolomics study

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