Radiological features of childhood giant cavernous malformations

Özgen, Burçe; Senocak, Efsun; Oğuz, Kader K.; Söylemezoğlu, Figen; Akalan, Nejat

doi:10.1007/s00234-010-0783-5

Cited by 21 publications

(15 citation statements)

References 37 publications

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“…The reported MRI features of GCMs include non-enhancing multi-cystic lesions with mixed intensity and a surrounding hemosiderin ring, large masses with a "salt and pepper" appearance, and spherical lesions consisting of acute and subacute hematomas. 24 The presentation after contrast injection is highly inconsistent, ranging from nonexistent to intense enhancement. 9,14 GCMs can also appear as complete solid masses and be misdiagnosed as neoplasms.…”

Section: Discussionmentioning

confidence: 99%

Rare asymptomatic giant cerebral cavernous malformation in adults: two case reports and a literature review

Zhen

Wang

2020

J Int Med Res

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Cavernous malformations are benign vascular malformations. Giant cavernous malformations are very rare. All reported cases have been symptomatic because of the large size and compression of the surrounding brain tissue. We report two asymptomatic cases of giant cavernous malformation that were both misdiagnosed as neoplasms because of their atypical presentations. The first case was a 54-year-old man whose computed tomography and magnetic resonance imaging scans revealed an inhomogeneous lesion of 6 cm diameter and mild enhancement in the left frontal lobe. A left lateral supraorbital and transcortical approach was applied and the lesion was completely removed. The second case was a 36-year-old man with an irregular large mass in the parasellar region. Craniopharyngioma was suspected and gross total resection was performed. Post-surgical pathological analyses confirmed the diagnoses as cavernous malformations. Both patients recovered uneventfully. The rare asymptomatic giant cavernous malformations reported here in adults had benign behavior for this specific disease entity. The different clinical characteristics of ordinary cavernous malformation and adult and pediatric giant cavernous malformation imply complex and distinct genetic backgrounds. Concerns should be raised when considering giant cavernous malformation as a differential diagnosis for atypical large lesions. Surgical resection is recommended as the primary treatment option.

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Section: Discussionmentioning

confidence: 99%

Rare asymptomatic giant cerebral cavernous malformation in adults: two case reports and a literature review

Zhen

Wang

2020

J Int Med Res

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“…Their clinical presentation depends on size and location, and is affected by recent episodes of bleeding. GCM occur more often in children and adolescents (12). In children they are frequently associated with intractable epilepsy (13,14).…”

Section: Discussionmentioning

confidence: 99%

Giant Cavernous Malformations in Young Adults: Report of two cases, Radiological Findings and Surgical Consequences

Parizel

Menovsky

Lammens

et al. 2014

Journal of the Belgian Society of Radiology

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Cerebral cavernous malformations, also known as cavernous angioma or cavernoma, are a type of vascular disorder. they consist of abnormally large vascular cavities or sinusoid channels of varying size. the majority of cavernous malformations in the brain are small and do not always present with symptoms. a minority of large cavernous malformations, known as giant cavernous malformations (GCm), can cause neurological symptoms (such as headaches, focal neurologic deficits and seizures), which are probably related to hemorrhage and mass effect. GCm grow steadily in size over time, due to repetitive episodes of bleeding. the purpose of this paper is to document two case reports of patients with GCm, illustrate the radiological appearance, discuss the neurosurgical consequences, and to provide a literature analysis.

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“…Histologically, large CM do not differ from the smaller ones, and only the diameter and radiological characteristics differentiate them 2,3,11 . Although they are much more common in the supratentorial portion, they can occur in any region of the neuroaxis.…”

Section: Introduction Case Presentationmentioning

confidence: 95%

“…Radiological findings that can raise the diagnosis of a large cavernoma include the presence of a large intra-axial hemorrhagic mass, with multicystic appearance, surrounding hemosiderin ring, fluid-fluid levels with edema and mass effect 3 . These characteristics are quite variable, making it initially misdiagnosed as brain tumors or other vascular malformations.…”

Section: Introduction Case Presentationmentioning

confidence: 99%

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Large cavernous malformations in infant

Britz¹,

Sonda²,

Calloni³

et al. 2021

jbnc

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Cavernous malformations are rare vascular malformations in the central nervous system. We present the case of a 2-month-old female patient who presented tonic-clonic seizures, with no previous history of seizures. Magnetic resonance imaging showed a 5.6 cm tumor in the left parieto-occipital region. The radiological aspect of the tumor initially suggested an anaplastic meningioma. After surgical treatment and anatomopathological analysis, it was found to be a cavernous malformation. Cavernous malformations, or cavernomas, are rare lesions and even more rare is the occurrence of large cavernomas. In the pediatric population, although still quite rare, they usually are presented as larger cavernomas. Surgical resection is considered the most effective treatment.

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Radiological features of childhood giant cavernous malformations

Abstract: In children, a GCM should be considered in case of very large hemorrhagic intra-axial mass with "bubbles of blood" multicystic appearance, surrounding hemosiderin ring, fluid-fluid levels, and accompanying edema-mass effect, especially in the periatrial location.

Cited by 21 publications

References 37 publications

Rare asymptomatic giant cerebral cavernous malformation in adults: two case reports and a literature review

Rare asymptomatic giant cerebral cavernous malformation in adults: two case reports and a literature review

Giant Cavernous Malformations in Young Adults: Report of two cases, Radiological Findings and Surgical Consequences

Large cavernous malformations in infant

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