Radiological factors related to pre-operative hearing levels in patients with vestibular schwannomas

Gerganov, Venelin; Nouri, Mohsen; Stieglitz, Lennart; Giordano, Mario; Samii, M.; Samii, Amir

doi:10.1016/j.jocn.2008.08.029

Cited by 13 publications

(10 citation statements)

References 16 publications

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“…VS side and VS stage showed no significant correlation with audiologic deterioration, similar to findings in literature (8,9,17,18,36). Increasing age showed a significant relationship with worse hearing, both in the VS affected as in the unaffected group.…”

Section: Predictors Of Change In Audiologic Functionsupporting

confidence: 88%

Predictors of Volumetric Growth and Auditory Deterioration in Vestibular Schwannomas Followed in a Wait and Scan Policy

Langenberg¹,

Bondt²,

Nelemans³

et al. 2011

Otology &Amp; Neurotology

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Hypointensity on T2-weighted image of the affected labyrinth will result in a significant faster deterioration of hearing. Hearing loss was more profound, and hearing will deteriorate significantly faster in patients presenting with complaints of hearing loss. Significant growth during the first year of FU predicts further growth during FU. Sequential MRI cannot be substituted by audiologic examinations solely because increase in VS volume does not correlate with audiologic deterioration significantly.

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Section: Predictors Of Change In Audiologic Functionsupporting

confidence: 88%

Predictors of Volumetric Growth and Auditory Deterioration in Vestibular Schwannomas Followed in a Wait and Scan Policy

Langenberg¹,

Bondt²,

Nelemans³

et al. 2011

Otology &Amp; Neurotology

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“…In contrast, six studies supported the correlation between hearing loss and tumor size/volume (9,14,15,(24)(25)(26). In a pilot study with a small sample size (n = 44), Day et al reported a trend correlation between tumor size and audiometric configuration with small tumor (<1 cm) in normal and rising types, medium tumor (1.0-2.5 cm) in mid-and high-frequency hearing loss, and large tumor (>2.5 cm) in flat and deafness types (14).…”

Section: Tumor Size/volumementioning

confidence: 85%

“…), pathological alteration in the inner ear, aberrant inflammatory response, gene mutation, aberrant DNA methylation, etc. (9)(10)(11)(12)(13). But the existing data remains controversial.…”

Section: Introductionmentioning

confidence: 99%

Current Understanding of Hearing Loss in Sporadic Vestibular Schwannomas: A Systematic Review

Gan

Zhang

et al. 2021

Front. Oncol.

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ObjectiveHearing loss is the most common initial symptom in patients with sporadic vestibular schwannomas (SVS). Hearing preservation is an important goal of both conservative and surgical therapy. However, the mechanism of SVS-associated hearing loss remains unclear. Thus, we performed this systematic review to summarize the current understanding of hearing loss in the SVS and distill a testable hypothesis to further illuminate its underlying mechanism.MethodsA systematic review querying four databases (PubMed, Medline, Embase, and Web of Science) was performed to identify studies evaluating hearing loss in patients with SVS and exploring the potential mechanisms of hearing impairment.ResultsA total of 50 articles were eligible and included in this review. After analysis, the retrieved studies could be categorized into four types: (1) 29 studies explore the relationship between hearing loss and the growth pattern of the tumor (e.g., tumor size/volume, growth rate, tumor location, etc.); (2) ten studies investigate the potential role of cochlear dysfunction in hearing deterioration, including structural abnormality, protein elevation in perilymph, and cochlear malfunctioning; (3) two studies looked into SVS-induced impairment of auditory pathway and cortex; (4) in the rest nine studies, researchers explored the molecular mechanism underlying hearing loss in SVS, which involves molecular and genetic alterations, inflammatory response, growth factors, and other tumor-associated secretions.ConclusionsMultiple factors may contribute to the hearing impairment in SVS, including the growth pattern of tumor, cochlear dysfunction, impairment of auditory pathway and cortex, genetic and molecular changes. However, our current understanding is still limited, and future studies are needed to explore this multifactorial hypothesis and dig deeper into its underlying mechanism.

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“…. the shape of VS was classified as oval (the shortest axial diameter <90% of the longest diameter), round (the shortest axial diameter 90% of the longest diameter) or multi-lobulated; 6 . the surface of the lesion was classified as smooth or irregular; 7 .…”

Section: Methodsmentioning

confidence: 99%

“…The maximal diameter and volume of the VS were calculated. Further tumor characteristics that were gathered were: the shape of VS was classified as oval (the shortest axial diameter <90% of the longest diameter), round (the shortest axial diameter ≥90% of the longest diameter) or multi-lobulated; 6 the surface of the lesion was classified as smooth or irregular; 7 the internal structure of the lesion was classified as cystic or homogeneous; and the major axis of tumor growth was also described in order to analyse a correlation between the edema location and the potential tumor compressive effect. …”

Section: Methodsmentioning

confidence: 99%

Imaging features and classification of peritumoral edema in vestibular schwannoma

et al. 2019

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Background Peritumoral edema (PTE) is rarely present in patients with vestibular schwannomas (VS). We studied the correlation between radiological tumor characteristics and the presence of edema, describe its magnetic resonance imaging features and classify the different edema patterns. Methods We analysed 605 consecutive patients treated for VS at our Institute. PTE was found in 30 patients, studied on fluid attenuated inversion recovery sequences and categorised as involving the brachium pontis, cerebellum and/or brainstem. Tumor volume, shape, surface, internal structure and axis of growth were evaluated and compared to a matched series of 30 patients without PTE. Results In our population of patients, 5% showed PTE. Edema involved the brachium pontis in 22 cases (88%), cerebellum in 15 (60%) and brainstem in 3 (12%). PTE was classified as mild (one region involved), moderate (two regions) and severe (three regions). Edema was present not only perpendicular to the major tumor growth axis but also parallel to it (91%). The difference between the two groups in regards to tumor shape and surface was not significant. We found no correlation between tumor and edema volumes. Conclusions VS can cause PTE, but its incidence is less frequent than in skull base meningiomas. PTE involves most frequently the brachium pontis, followed by the cerebellum and brainstem. Its occurrence correlates with tumor size but not with other radiological VS features. PTE is not always located perpendicular to the major axis of tumor growth, which indicated that the compressive theory proposed for meningiomas is not plausible explanation for its manifestation.

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Radiological factors related to pre-operative hearing levels in patients with vestibular schwannomas

Cited by 13 publications

References 16 publications

Predictors of Volumetric Growth and Auditory Deterioration in Vestibular Schwannomas Followed in a Wait and Scan Policy

Predictors of Volumetric Growth and Auditory Deterioration in Vestibular Schwannomas Followed in a Wait and Scan Policy

Current Understanding of Hearing Loss in Sporadic Vestibular Schwannomas: A Systematic Review

Imaging features and classification of peritumoral edema in vestibular schwannoma

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