Radiological evidence of progression of bronchiectasis

Munro, N. C.; Han, Lizhi; Currie, D C; Strickland, Basil; Cole, P J

doi:10.1016/s0954-6111(06)80006-5

Cited by 16 publications

(6 citation statements)

References 10 publications

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“…Symptom-free progression of pulmonary changes detected by HRCT in patients with primary hypogammaglobulinemia has been recently suggested in two studies [12,13]. However, this feature has also been observed in immunocompetent hosts with bronchiectasis and chronic obstructive pulmonary disease (COPD) if inflammation or chronic bronchial infection was associated [27]. For this reason, it is difficult to attribute all progression of lung disease to inadequate treatment with IVIG in patients with primary antibody deficiency syndromes.…”

Section: Discussionmentioning

confidence: 99%

Immunoglobulin therapy to control lung damage in patients with common variable immunodeficiency

Gracia¹,

Vendrell

Álvarez³

et al. 2004

International Immunopharmacology

139

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Section: Discussionmentioning

confidence: 99%

Immunoglobulin therapy to control lung damage in patients with common variable immunodeficiency

Gracia¹,

Vendrell

Álvarez³

et al. 2004

International Immunopharmacology

139

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“…Although historically the serial evaluation of chest radiographs has been reported as being suitable to document progression of CF [42] and non-CF bronchiectasis [43], it has been well established that HRCT of the chest provides more detailed information [44][45][46]. Utilising HRCT scans and a validated CT score in this study is a major strength in comparison with other work that uses chest radiograph assessment to compare with exercise.…”

Section: Discussionmentioning

confidence: 99%

HRCT lung abnormalities are not a surrogate for exercise limitation in bronchiectasis

Edwards

Narang²,

Li³

et al. 2004

European Respiratory Journal

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In paediatric bronchiectasis, there has been limited work on the relationship between disease severity as assessed by exercise limitation and high resolution computed tomography (HRCT).An observational study was performed on 36 children who completed a questionnaire, physical examination, spirometry and sputum analysis, followed by a low dose of radiation protocol chest computed tomography (CT) scan and cycle ergometry incremental exercise test. A modified Bhalla score was used to score the HRCT abnormalities. The exercise variables used to assess functional status were heart rate, oxygen consumption, oxygen saturations and time of exercise. The results were compared with established normal paediatric values.The median (range) age of the children was 13 yrs (10.6-17.1). Age, sex, height, weight or pubertal status were equally distributed between the children with cystic fibrosis (CF) or non-CF bronchiectasis. The children with non-CF bronchiectasis had a lower median forced expiratory volume in one second % predicted than the children with CF (69% versus 76%, respectively). The distribution of lung disease differed between the two groups. The children with CF bronchiectasis had predominantly right upper lobe disease, and scored higher for the presence and extent of bronchiectasis. Otherwise, there was no statistical difference in the overall CT score or the individual CT parameters between the groups. There was evidence of exercise limitation in both CF and non-CF bronchiectasis compared to normal children. No consistent relationships were identified between the lung function parameters, HRCT findings or exercise parameters in either disease group.In this study, high resolution computed tomography features were not found to be markers of exercise capacity. As spirometry, high resolution computed tomography features and exercise testing give different information in children with cystic fibrosis and non-cystic fibrosis bronchiectasis, the current authors suggest all three may be required for the comprehensive assessment of respiratory status.

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“…The baseline Bhalla score was 9.52 ± 3.14 (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19), and the mean Bhalla score significantly increased over the follow-up period (10.06 ± 3.40, p < 0.001). The Bhalla score increased in 56 patients (36.1%) but did not change in 87 (56.1%) and decreased in 12 (7.7%).…”

Section: Radiologic Progressionmentioning

confidence: 93%

“…Several studies investigated the CT score in non-CF bronchiectasis; however, they had an inadequate number of study participants or follow-up time. 8,9 The aims of this study were to assess the radiologic progression by comparing serial CT scans using the Bhalla scoring system and to determine the factors that affect CT score change in non-CF bronchiectasis.…”

Section: Introductionmentioning

confidence: 99%

Factors associated with radiologic progression of non‐cystic fibrosis bronchiectasis during long‐term follow‐up

et al. 2016

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Background and objective: Non-cystic fibrosis (CF) bronchiectasis is a chronic airway inflammatory disease, exhibiting a diverse array of clinical courses. The purpose of this study was to determine the factors that predict radiologic progression of non-CF bronchiectasis during a long-term follow-up. Methods: We reviewed the electronic medical records that included pulmonary function test data from non-CF bronchiectasis patients, who were older than 18 years of age with a follow-up of computerized tomography for more than 5 years. The original Bhalla score was used to determine the radiologic severity of non-CF bronchiectasis. Results: A total of 155 patients (mean age, 59.6 years; male, 45.2%) were included for the final analysis. The mean follow up time was 7.11 ± 1.42 (5-10) years. The baseline Bhalla score was 9.52 ± 3.14 (4-19), and the change of Bhalla score was 0.55 ± 1.14 (À2 to 5). The Bhalla score was increased in 56 patients (36.1%) but not in 99 patients (63.9%). The Bhalla score change was significantly associated with the age at diagnosis (p = 0.037), body mass index (BMI, p = 0.012), chronic infection of Pseudomonas aeruginosa (p = 0.005) or isolation of nontuberculous mycobacterium (p = 0.042) in respiratory specimens. In a multivariate analysis, BMI and isolation of P. aeruginosa were significantly related with the Bhalla score change. Conclusion: The radiologic progression of non-CF bronchiectasis was associated with lower BMI and isolation of P. aeruginosa in respiratory specimens.

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Radiological evidence of progression of bronchiectasis

Cited by 16 publications

References 10 publications

Immunoglobulin therapy to control lung damage in patients with common variable immunodeficiency

Immunoglobulin therapy to control lung damage in patients with common variable immunodeficiency

HRCT lung abnormalities are not a surrogate for exercise limitation in bronchiectasis

Factors associated with radiologic progression of non‐cystic fibrosis bronchiectasis during long‐term follow‐up

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