Radiological Demonstration of Variations in the Fluid Content of the Small Intestine during Dumping Attacks

Amdrup, E; Hjorth, P; Jb, Jørgensen

doi:10.1259/0007-1285-31-370-542

Cited by 11 publications

(3 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The third patient also had dumping symptoms preoperatively, but they intensified after PCV. In this patient dumping could not be provoked by oral intake of hypertonic glucose, and radiologic signs [12] of dumping were not observed. However, symptoms were well described and disturbing to the patient, who was given a Visick grade of IV [13].…”

Section: Sequelaementioning

confidence: 56%

Follow‐up of 100 patients five to eight years after parietal cell vagotomy

Jensen¹,

Amdrup²

1978

World j. surg.

View full text Add to dashboard Cite

Recurrent ulcer developed in 9 out of 100 patients followed up for 5 to 8 years after parietal cell vagotomy (PCV) for duodenal ulcer. The time of recurrence was often surprisingly late, the latest occurring in the 6th year. Patients with recurrence did not differ significantly from the total group of patients with respect to sex, preoperative age, weight, or gastric acid secretion. Patients with recurrent ulcer were evenly distributed among the surgeons who performed the operations, and showed no obvious difference in reduction in spontaneous or in pentagastrin‐ and insulin‐stimulated acid secretion, compared to the symptom‐free patients. In 3 patients recurrence might have been related to abuse of salicylates and tobacco, and possibly to mental stress. These ulcers healed in response to nonsurgical treatment and the patients have remained symptom free for several years. In 6 patients, antrectomy was required. Sequelae occurred very infrequently, but in 1 patient dumping complaints were severe. An overall clinical assessment by Visick grading placed 72 patients in grade I, 14 in grade II, 4 in grade III, and 10 in grade IV. The failures included 6 patients who required reoperation for recurrent ulcer, 2 who required reoperation for gastric stasis, and the patient with severe dumping.

show abstract

Section: Sequelaementioning

confidence: 56%

Follow‐up of 100 patients five to eight years after parietal cell vagotomy

Jensen¹,

Amdrup²

1978

World j. surg.

View full text Add to dashboard Cite

show abstract

“…Early symptoms consist of neurovascular and gastrointestinal symptoms appearing within 30 min after eating, while the late symptoms (sweating, paleness, fatigue, muscular weakness, blurred consciousness, anxiety, tremor, tachycardia) appear after 2 h or later and are related to hypoglycaemia. After test meals or oral glucose tolerance tests, gastrectomised patients show rapid gastric emptying and increased intestinal motility [4,5,6,7] which are thought to be responsible for the quick and steep rise in plasma glucose concentration. At first, the abnormal hyperglycaemic response itself was thought to be responsible for the pronounced concomitant hyperinsulinaemia seen in these patients [1] but similar plasma glucose concentrations obtained by i. v. glucose infusion do not induce equally high insulin and Diabetologia (1998) Summary The plasma concentrations of the insulinotropic incretin hormone, glucagon-like peptide-1 (GLP-1) are abnormally high after oral glucose in partially gastrectomised subjects with reactive hypoglycaemia, suggesting a causal relationship.…”

mentioning

confidence: 99%

Exaggerated secretion of glucagon-like peptide-1 (GLP-1) could cause reactive hypoglycaemia

1998

View full text Add to dashboard Cite

Postprandial symptoms, known as the dumping syndrome, often complicate total or partial gastrectomy and can be classified as ªearlyº or ªlateº dumping [1,2,3] according to the temporal relation to the preceding meal. Early symptoms consist of neurovascular and gastrointestinal symptoms appearing within 30 min after eating, while the late symptoms (sweating, paleness, fatigue, muscular weakness, blurred consciousness, anxiety, tremor, tachycardia) appear after 2 h or later and are related to hypoglycaemia. After test meals or oral glucose tolerance tests, gastrectomised patients show rapid gastric emptying and increased intestinal motility [4,5,6,7] which are thought to be responsible for the quick and steep rise in plasma glucose concentration. At first, the abnormal hyperglycaemic response itself was thought to be responsible for the pronounced concomitant hyperinsulinaemia seen in these patients [1] but similar plasma glucose concentrations obtained by i. v. glucose infusion do not induce equally high insulin and Diabetologia (1998) Summary The plasma concentrations of the insulinotropic incretin hormone, glucagon-like peptide-1 (GLP-1) are abnormally high after oral glucose in partially gastrectomised subjects with reactive hypoglycaemia, suggesting a causal relationship. Because of the glucose-dependency of its effects, it is impossible to induce hypoglycaemia in normal subjects in the basal state by exogenous GLP-1, regardless of dose. To further assess the role of the incretin hormones in reactive hypoglycaemia, we reproduced the glucose and hormone profiles of the patients with reactive hypoglycaemia in 8 healthy volunteers in 4 separate protocols: 1) i. v. infusion of glucose (25 g) alone, 2) glucose together with i. v. GLP-1 infusion, and 3) and 4) glucose together with i. v. infusion of the other incretin hormone, glucose-dependent insulinotropic polypeptide (GIP), at two different infusion rates. The plasma glucose, GLP-1 and GIP concentrations (low dose) obtained were comparable with those of the patients. With GLP-1, infusion of a total of 33.4 ± 1.3 g glucose was required to obtain plasma glucose concentrations similar to those obtained by glucose infusion alone; with low GIP, 28.0 ± 1.2 g and with high GIP 38.4 ± 3.5 g. Insulin concentrations increased 10-fold with GLP-1 compared with i. v. glucose alone, but less with high and low GIP. In contrast, C-peptide concentrations were similar after GLP-1 and high GIP. After termination of i. v. glucose the lowest glucose concentrations were 4.5 (3.7±4.9) (median, range) for glucose alone; 2.4 (1.9±2.8) mmol/l with GLP-1; 3.7 (2.6±4.0) with low GIP and 3.3 (2.1±4.2 ) with high GIP. Thus, the exaggerated GLP-1 response to nutrients in patients with accelerated gastric emptying could be responsible for their high incidence of postprandial reactive hypoglycaemia. [Diabetologia (1998)

show abstract

“…Goligher and Riley [8] among others could not find any correlation between the stomal size and em ptying time using ordinary barium contrast medium. Later, how ever, it has been shown after addition of hypertonic glucose solution to the contrast medium, that a small stoma gives rise to prolonged em ptying tim e, decreased reaction of the small intestine and less postcibal sym ptom s as compared with a larger stoma [1,3,13]. In many clinical series it has been shown, that there are rem arkably few postcibal sym ptom s, when the stoma has a diam eter smaller than th at of the jejunum [2,4,10,14,19,21,22].…”

mentioning

confidence: 99%

Influence of a Small Stoma on Late Results after Billroth II Resection

Almersjoe¹

1964

Digestion

View full text Add to dashboard Cite

Radiological Demonstration of Variations in the Fluid Content of the Small Intestine during Dumping Attacks

Cited by 11 publications

References 2 publications

Follow‐up of 100 patients five to eight years after parietal cell vagotomy

Follow‐up of 100 patients five to eight years after parietal cell vagotomy

Exaggerated secretion of glucagon-like peptide-1 (GLP-1) could cause reactive hypoglycaemia

Influence of a Small Stoma on Late Results after Billroth II Resection

Contact Info

Product

Resources

About