Radiological and Clinical Pneumonitis After Stereotactic Lung Radiotherapy: A Matched Analysis of Three-Dimensional Conformal and Volumetric-modulated Arc Therapy Techniques

Pulmonary function and quality of life after VMAT-based stereotactic ablative radiotherapy for early stage inoperable NSCLC: a prospective study

“…However, as previously mentioned, in the present study we did not find any correlation between normal lung dose-volume parameters and the occurrence of lung toxicity (clinical and radiological). With regards to the possible negative impact of the use of VMAT, a previous publication showed no difference in the incidence of radiation pneumonitis between 3D-CRT and VMAT [17].…”

“…Lung toxicity was graded according to RTOG acute radiation toxicity score (for events occurring within 6 months from the start of radiation treatment) or RTOG late radiation toxicity score (for events occurring after 6 months) (http://www.rtog.org/members/toxicity). Acute radiological toxicity was scored using a five-point scoring system developed by Vrije University, modified from Kimura et al [16] (1 = diffuse consolidation, 2 = patchy consolidation, 3 = diffuse "ground glass opacity", 4 = patchy "ground glass opacity", 5 = no changes) [17]. Late radiological toxicity was scored according to the Koenig's Scale (0 = absence of changes, 1 = modified conventional pattern, 2 = mass like pattern, 3 = scar like pattern) [18].…”

Synergy of radiotherapy and PD-1 blockade in Kras-mutant lung cancer

“…These patients are likely to have poor lung reserve function due to smoking, chronic obstructive pulmonary disease, advanced disease, and prior cancer therapy, and cumulative toxicity of pneumonitis would be of particular concern. RT of lung malignancies almost always inevitably involves normal lung parenchyma, which could potentially lead to variable extents of pulmonary inflammation and radiation pneumonitis (59). Although clinical pneumonitis rates for the αPD-1 antibody nivolumab are similar to or lower than those of other drugs commonly used in NSCLC (docetaxel: 4.6%, ref.…”

A comparison of three different VMAT techniques for the delivery of lung stereotactic ablative radiation therapy

“…Furthermore, dose is being deposited through non‐coplanar angles with the NCA technique, further reducing the MLD. In a matched analysis study, Palma et al investigated radiobiological and clinical pneumonitis after both VMAT (RapidArc) and 3DCRT and concluded that there was no difference in the severity of clinical or radiobiological sequelae after treatment 10. Figure 2 displays the reduced dose wash to the contralateral lung with both the PA and NCA techniques when compared to the FA technique.…”