Radiologic manifestations of small-bowel toxicity due to floxuridine therapy

Kelvin, FM; Gramm, H F; Gluck, WL; Lokich, J

doi:10.2214/ajr.146.1.39

Cited by 27 publications

(8 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Barium studies may reveal thickened or effaced folds and tubular narrowing of the duodenum and proximal jejunum, producing a classic "pipe stem" appearance (41). Other causes.-Other causes of focally thickened irregular folds include 5-FUDR (floxuridine) toxicity involving the terminal ileum or neo-terminal ileum (42), opportunistic infection of the ileum by cytomegalovirus in patients with AIDS (43), and malignant cecal tumors (including cecal carcinoma and lymphoma) directly invading the terminal ileum via the ileocecal valve.…”

Section: Irregular-segmental Thickeningmentioning

confidence: 99%

Pattern Approach for Diseases of Mesenteric Small Bowel on Barium Studies

Levine¹,

Rubesin²,

Laufer³

2008

Radiology

View full text Add to dashboard Cite

Despite an array of sophisticated imaging techniques, the barium examination remains a valuable diagnostic test for evaluating structural abnormalities of the small bowel. Most patients can be examined with conventional small-bowel follow-through studies, in which periodic imaging of the entire small bowel is performed by using fluoroscopic guidance; however, some patients may benefit from enteroclysis, in which contrast agents are instilled into the small bowel via a catheter placed in the proximal jejunum for optimal distention and better depiction of individual small-bowel loops. This review for residents discusses the major diseases involving the mesenteric small bowel and presents a pattern approach for the wide spectrum of abnormalities found on barium studies, including polypoid lesions, cavitated lesions, annular lesions, outpouchings, separation of loops, abnormal folds, nodules without abnormal folds, and dilated small bowel.

show abstract

Section: Irregular-segmental Thickeningmentioning

confidence: 99%

Pattern Approach for Diseases of Mesenteric Small Bowel on Barium Studies

Levine¹,

Rubesin²,

Laufer³

2008

Radiology

View full text Add to dashboard Cite

show abstract

“…The mural thickening and effacement of the mucosa are reversible [3,36,37]. A similar pattern of ischemic or ulcerative enterocolitis can be observed during treatment of rheumatoid arthritis with gold injections (Fig.…”

Section: Intestinal Ischemia and Mesenteric Vein Thrombosismentioning

confidence: 82%

Drug-induced disorders of the small bowel

Neitlich

Burrell

1999

Abdominal Imaging

View full text Add to dashboard Cite

“…Floxuridine has been associated with ileal strictures on the basis of an early small case series of patients studied with small bowel fluoroscopy (18). Given that the symptoms and radiographic changes were found to be reversible, it is likely that the radiographic findings were a manifestation of enteritis rather than fibrosis manifesting in the ileum.…”

Section: *Ardsmentioning

confidence: 99%

Unintended Consequences of Systemic and Ablative Oncologic Therapy in the Abdomen and Pelvis

et al. 2018

View full text Add to dashboard Cite

Human cancers are genetically complex and diverse. Although advances in oncologic therapy aim to define and target unique steps in carcinogenesis, oncologists often rely on less discriminate anticancer therapies that have consequences for normal tissues. Even many of the so-called targeted therapies currently employed can adversely affect normal cells, leading to complications that necessitate dose reductions or cessation of specific therapies. This article explores the unintended consequences of currently employed systemic and ablative anticancer therapies that might manifest at imaging examinations of the abdomen and pelvis, including cytotoxic, molecular targeted, and immunologic agents; ablation; and hematopoietic stem cell transplant. Each of these treatments can have both major and minor unintended effects in the targeted organ(s), in local or adjacent structures, or at distant sites. Timely detection and reporting of adverse consequences of anticancer therapies by the astute imager can result in critical treatment modifications and/or lifesaving interventions; therefore, knowledge of these unintended effects is paramount for radiologists interpreting the results of imaging examinations in cancer patients. RSNA, 2018.

show abstract

Radiologic manifestations of small-bowel toxicity due to floxuridine therapy

Cited by 27 publications

References 11 publications

Pattern Approach for Diseases of Mesenteric Small Bowel on Barium Studies

Pattern Approach for Diseases of Mesenteric Small Bowel on Barium Studies

Drug-induced disorders of the small bowel

Unintended Consequences of Systemic and Ablative Oncologic Therapy in the Abdomen and Pelvis

Contact Info

Product

Resources

About