Radiologic Imaging Modalities for Colorectal Cancer

Liu, Wen; Zeng, Anrong; Tang, Hanzhou; Qiang, Jin Wei

doi:10.1007/s10620-021-07166-0

Cited by 1 publication

(1 citation statement)

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“…The diagnosis of CRC is based on an accurate anamnesis, followed by blood tests with the research of carcinoembryonic tumor marker (CEA), digital rectal examination and colonoscopy with biopsies. In addition, ultrasound, computed tomography (CT) and magnetic resonance imaging can be used to assess the extent of the tumor itself and the presence or absence of distant metastases [ 12 ]. More recently, clinicians are beginning to use the results of the molecular profile of CRC from biopsy, as it can serve to better define the prognosis and therapy of this neoplasia [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Natural essential oils as a new therapeutic tool in colorectal cancer

et al. 2022

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Colorectal cancer (CRC) is the third most revalent type of cancer in the world and the second most common cause of cancer death (about 1 million per year). Historically, natural compounds and their structural analogues have contributed to the development of new drugs useful in the treatment of various diseases, including cancer. Essential oils are natural odorous products made up of a complex mixture of low molecular weight compounds with recognized biological and pharmacological properties investigated also for the prevention and treatment of cancer. The aim of this paper is to highlight the possible role of essential oils in CRC, their composition and the preclinical studies involving them. It has been reviewed the preclinical pharmacological studies to determine the experimental models used and the anticancer potential mechanisms of action of natural essential oils in CRC. Searches were performed in the following databases PubMed/Medline, Web of science, TRIP database, Scopus, Google Scholar using appropriate MeSH terms. The results of analyzed studies showed that EOs exhibited a wide range of bioactive effects like cytotoxicity, antiproliferative, and antimetastatic effects on cancer cells through various mechanisms of action. This updated review provides a better quality of scientific evidence for the efficacy of EOs as chemotherapeutic/chemopreventive agents in CRC. Future translational clinical studies are needed to establish the effective dose in humans as well as the most suitable route of administration for maximum bioavailability and efficacy. Given the positive anticancer results obtained from preclinical pharmacological studies, EOs can be considered efficient complementary therapies in chemotherapy in CRC.

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Section: Introductionmentioning

confidence: 99%