Radiologic Contrast-Induced Nephropathy

Radiocontrast-associated renal dysfunction: incidence and risk factors.

“…Older retrospective studies and more recent prospective studies do not agree on the association of previous volume depletion with contrast-induced nephropathy [1]. When we used a scatter plot and the analysis of variance model, no correlation is present.…”

“…This group was chosen for its large proportion of elderly and/or diabetic patients, many of whom had underlying renal insufficiency and were presumably at increased risk for contrast-induced nephropathy [1]. Additional analyses were conducted by using analysis of variance models on 381 patients (patients were excluded if they had no creatinine data on day 1 through day 3).…”

Acute Renal Failure in Rats

“…Contrast media cannot be excluded as one of several etiologic factors in about 10 per cent of the cases of acute renal failure. Such cases are described as contrast medium induced renal failure even if the patient has received a number of different nephrotoxic drugs (3,9). The larger the contrast medium dose and the lower the glomerular filtration rate before contrast medium injection, the greater the risk that acute renal failure will occur (3,9).…”

“…Such cases are described as contrast medium induced renal failure even if the patient has received a number of different nephrotoxic drugs (3,9). The larger the contrast medium dose and the lower the glomerular filtration rate before contrast medium injection, the greater the risk that acute renal failure will occur (3,9). Our present investigations in rats do not cover interactions between contrast media and the abovementioned etiologic factors in acute renal failure.…”

Intravascular Radiographic Contrast Media: Issues for Family Physicians

“…45 ,55,57,59 Advanced heart failure with low cardiac output is a risk factor for CAN.56 Dehydration has been implicated but has not been proved to be a risk factor in prospective studies. 52 Multiple myeloma, once thought to be a strong risk factor for CAN, does not appear to be a risk factor alone unless renal involvement from the disease is present. 47 ,49,52 Advanced age does not appear to be an independent risk factor.…”