Radiologic Assessment of Intranodal Vascularity in Head and Neck Squamous Cell Carcinoma

Lamer, S; Sigal, R.; Lassau, Nathalie; Bosq, Jacques; Frouin, F.; Paola, M. Di; Mamelle, G.; Leclère, J.; Bittoun, J.; Paola, R. Di

doi:10.1097/00004424-199611000-00001

Cited by 19 publications

(5 citation statements)

References 22 publications

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“…The previously demonstrated correlation between the number of blood flows visualized with DUS and the number of vascular structures visualized on standard HES stained tissue section was confirmed. 30 At day 17, the histological numbering of blood vessels in SFV-IL12 treated tumor was significantly lower than in control and SFV-LacZ-treated mice, where, in contrast, hypervascular development could be observed ( Figure 6). Histological analysis further revealed that, 3 days after SFV injection (day 13), tumor necrosis in SFV-LacZ and SFV-IL12-treated tumor was slightly higher (20-30%) than in control tumors (10-20%), probably as a consequence of cell death induced by SFV injection.…”

Section: Sfv-il12 Inhibited Tumor Neovascularization In Vivo As Monimentioning

confidence: 91%

“…Several studies have shown that color DUS is able to detect in situ neovascularization in solid human tumors. [28][29][30][31][32] Recently, we have shown that color DUS was able to visualize vessels of diameter greater than 100 m, and thus appropriate for the evaluation of angiogenesis in human malignant melanoma. Indeed, the color DUS results correlated with immunohistochemical staining, as regards vascular density and number of vessels of diameter above 100 m.…”

Section: Introductionmentioning

confidence: 99%

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Transfer of the murine interleukin-12 gene in vivo by a Semliki Forest virus vector induces B16 tumor regression through inhibition of tumor blood vessel formation monitored by Doppler ultrasonography

Asselin‐Paturel

Lassau

et al. 1999

Gene Ther

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To elucidate further the potential of a Semliki Forest virus IL-12 genes induced tumor regression, the antiangiogenic-(SFV) vector in vivo for gene therapy, we constructed a activity of SFV-IL12 was investigated using Doppler ultravector, SFV-IL12, to transfer murine IL-12 genes into sonography (DUS). SFV-IL12 inhibited in situ neovascutumors. A single intratumoral injection of established B16 larization within the tumor, without affecting the resistance murine melanoma with SFV-IL12 resulted in a significant index of pre-existing intratumoral blood flows. In addition, inhibition of tumor growth, while injection with SFV-LacZ histological analysis of SFV-IL12-treated tumors showed had no effect. This antitumoral activity correlated with an massive tumor necrosis induced by SFV-IL12 treatment. increase of IFN␥ production, MIG and IP-10 mRNA These data indicate that SFV-IL12 inhibits tumor growth expression, both at the tumor site and at the periphery. In through its antiangiogenic activity, demonstrated for the contrast, no increase in CTL-or NK cell-mediated cytotoxic first time in vivo by DUS, and suggest that the SFV vector response could be detected, ruling out the involvement of may be a novel valuable tool in tumor gene transfer. T and NK cell cytotoxicity. To determine how the transfer of

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Section: Sfv-il12 Inhibited Tumor Neovascularization In Vivo As Monimentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Transfer of the murine interleukin-12 gene in vivo by a Semliki Forest virus vector induces B16 tumor regression through inhibition of tumor blood vessel formation monitored by Doppler ultrasonography

Asselin‐Paturel

Lassau

et al. 1999

Gene Ther

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“…This became an established and measureable quantity with the advent of dynamic contrast enhanced magnetic resonance imaging (DCE-MRI), which measures time-dependent distribution of contrast agents 61, 62 . The heterogeneity can be quantified and has been shown to be a powerfully negative prognostic factor 63, 64 . Perfusion heterogeneity causes periodic and chronic deficits in metabolic substrates, particularly oxygen 65, 66 , and pH 48 .…”

Section: Introductionmentioning

confidence: 99%

Evolutionary dynamics of carcinogenesis and why targeted therapy does not work

2012

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“…[9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] Pharmacokinetically deˆned permeability provides a high sensitivity in classifying benign and malignant breast lesions. 10 Most head and neck tumors and uterine cervical tumors are squamous cell carcinomas, and radiation therapy is useful in the treatment of these tumors.…”

Section: Introductionmentioning

confidence: 99%

Dynamic MR Imaging and Radiotherapy

2002

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Dynamic MRI has been used to improve the detection of tumors and to make diŠerential diagnosis. Most malignant lesions show early enhancement and early washout of contrast media on dynamic MRI, but the characterization of the tumor remains unclear. Pharmacokinetic analysis of dynamic MRI can provide information about the permeability of contrast media in the tumor that may re‰ect the oxygen concentration of the tumor. This information may be useful in the prediction of a tumor's response to radiation therapy.

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Radiologic Assessment of Intranodal Vascularity in Head and Neck Squamous Cell Carcinoma

Abstract: Only one model of vascularization was extracted by FAMIS, with no difference between neoplastic and spared lymphoid areas. The presence of color-flow signals could help predict the response of metastatic lymph nodes to chemotherapy.

Cited by 19 publications

References 22 publications

Transfer of the murine interleukin-12 gene in vivo by a Semliki Forest virus vector induces B16 tumor regression through inhibition of tumor blood vessel formation monitored by Doppler ultrasonography

Transfer of the murine interleukin-12 gene in vivo by a Semliki Forest virus vector induces B16 tumor regression through inhibition of tumor blood vessel formation monitored by Doppler ultrasonography

Evolutionary dynamics of carcinogenesis and why targeted therapy does not work

Dynamic MR Imaging and Radiotherapy

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