Radiologic Appearance and Complications of Percutaneous Computed Tomography???Guided Radiofrequency-Ablated Pulmonary Metastases from Colorectal Carcinoma

Steinke, Karin; King, Julie; Glenn, Derek; Morris, David L.

doi:10.1097/00004728-200309000-00012

Cited by 114 publications

(86 citation statements)

References 27 publications

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“…The opacity increases in size from baseline to 1-to 3-month follow-up CT scans and then remains stable or decreases in size [43]. Follow-up CT imaging shows that the treated area can evolve in five different patterns: fibrosis, cavitation, nodule, atelectasis, and disappearance.…”

Section: Pretreatment Assessment Procedural Features and Postprocedmentioning

confidence: 97%

“…Intratumoral contrast uptake, tumor growth at the periphery of the ablation, or a 20% increase in longest tumor diameter strongly correlated with incomplete ablation [31]. At follow-up CT, the opacity will start to decrease in size as early as 4 weeks and up to 6 months [43].…”

Section: Pretreatment Assessment Procedural Features and Postprocedmentioning

confidence: 98%

“…The extent of the GGO surrounding the treated lesion on immediate postablation CT imaging has been shown to predict the effectiveness of thermal ablation. The tumor tissue is considered to be incorporated in the ablation zone when the GGO completely surrounded the tumor [31,43]. The GGO should encounter the treated tumor with a circumferential margin of at least 5 mm for complete tumor ablation [44].…”

Section: Pretreatment Assessment Procedural Features and Postprocedmentioning

confidence: 99%

See 2 more Smart Citations

Standards of Practice: Guidelines for Thermal Ablation of Primary and Secondary Lung Tumors

Pereira

Salvatore²

2012

Cardiovasc Intervent Radiol

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Section: Pretreatment Assessment Procedural Features and Postprocedmentioning

confidence: 97%

Section: Pretreatment Assessment Procedural Features and Postprocedmentioning

confidence: 98%

Section: Pretreatment Assessment Procedural Features and Postprocedmentioning

confidence: 99%

See 1 more Smart Citation

Standards of Practice: Guidelines for Thermal Ablation of Primary and Secondary Lung Tumors

Pereira

Salvatore²

2012

Cardiovasc Intervent Radiol

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“…The ablation zone is characterized by an increased size compared with the initial tumor diameter because of an intended incorporation of a safety margin and edematous and hemorrhagic changes at the periphery. 10,18 The ablation zone typically slowly decreases in size; at 3 months, it is still slightly larger than at baseline, and at 6 months, it is at the same size or smaller than before RF ablation. 18 Subsequently, the ablation zone slowly shrinks or becomes evenly stable.…”

mentioning

confidence: 99%

“…10,18 The ablation zone typically slowly decreases in size; at 3 months, it is still slightly larger than at baseline, and at 6 months, it is at the same size or smaller than before RF ablation. 18 Subsequently, the ablation zone slowly shrinks or becomes evenly stable. 18 Therefore, conventional response evaluation criteria in solid tumors (RECIST) cannot be applied to assessment of treatment response of pulmonary RF ablation.…”

mentioning

confidence: 99%

Pathomorphologic evaluation of pulmonary radiofrequency ablation

Clasen

Kröber

Kosan

et al. 2008

Cancer

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BACKGROUND.Radiofrequency (RF) ablation is an increasingly applied technique. Promising results of hepatic RF ablation raised expectations of its capabilities for treatment of primary and secondary lung tumors. Because of different thermal and electrical properties of lung tissue, compared with liver tissue, a simple analogy of tissue response is not possible. The authors aimed to evaluate the effectiveness of image‐guided pulmonary RF ablation and to characterize pathomorphology of tissue response.METHODS.RF ablations of 11 pulmonary malignancies in 9 patients were performed under computed tomography (CT)‐guidance. Three days after RF ablation, surgical resection was performed followed by pathologic examination. Specimens were evaluated macroscopically, histologically by hematoxylin and eosin (H & E) staining, terminal deoxy‐nucleotidyl transferase‐mediated nick end‐labeling (TUNEL), and electron microscopy.RESULTS.Tumor tissues and adjacent lung tissues were characterized by double‐strand fragmentation as determined by TUNEL. Ultrastructurally apoptotic bodies were found, indicating apoptotic cells. Criteria for tissue necrosis were not fulfilled by standard histological staining (H & E), showing preserved tissue architecture and only few microscopic cellular details suggestive of tumor regression. Because of DNA fragmentation, as determined by TUNEL and results from electron microscopy, the authors confirmed the tumor tissue to be completely ablated in 10 (90.9%) cases. However, in 2 cases, a safety margin was absent.CONCLUSIONS.CT‐guided pulmonary RF ablation of pulmonary malignancies is a locally effective treatment. Three days after RF ablation, tumor tissue seemed to be thermally fixed still showing characteristics of vital tumor tissue in standard histological staining; however the tissue proved to be in regression toward coagulative necrosis verified ultrastructurally and by TUNEL. Cancer 2008. © 2008 American Cancer Society.

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Risk factors for local progression after percutaneous radiofrequency ablation of lung tumors

Hiraki

Sakùrai

Tsuda

et al. 2006

Cancer

136

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Objectives: The aim of this study was to determine the relationship between paternal age at birth and the risk of obesity in young adulthood. Methods: Data from the medical birth register of Norway were linked with register data from the Norwegian National Conscript Service and the national statistics agency, Statistics Norway. This study used the data on 346,609 registered males who were born at term in single birth without physical anomalies during 1967–1984 and who were examined at the time of the mandatory military conscription (age 18–20 years). The relationship between paternal age at birth and the occurrence of obesity (body mass index (BMI) ≥ 30.0 kg/m2) at conscription was examined using a multinomial logistic regression analysis with BMI < 25.0 kg/m2 as the reference outcome category. Results: The relative risk of obesity at conscription increased linearly with increasing paternal age at birth but did not increase (P = 0.52) with maternal age at birth. Men born when their fathers were 50 years or older had a 55% (95% confidence interval (CI): 14%, 110%) higher relative risk of obesity than men born when their fathers were younger than 20 years of age, after adjustment for age at conscription, birth order, birth year, maternal age at birth, the mother's total number of children, and maternal and paternal education levels. Conclusions: The risk of obesity in young Norwegian men increases with advancing paternal age at birth but does not increase with advancing maternal age at birth. Am. J. Hum. Biol., 2013. © 2012Wiley Periodicals, Inc.

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Radiologic Appearance and Complications of Percutaneous Computed Tomography???Guided Radiofrequency-Ablated Pulmonary Metastases from Colorectal Carcinoma

Abstract: Image-guided pulmonary RFA is a safe minimally invasive therapy modality with acceptable morbidity. Ablated lesion size usually exceeds the dimensions of the initial tumor for the first 3 months after ablation and continuously shrinks thereafter.

Cited by 114 publications

References 27 publications

Standards of Practice: Guidelines for Thermal Ablation of Primary and Secondary Lung Tumors

Standards of Practice: Guidelines for Thermal Ablation of Primary and Secondary Lung Tumors

Pathomorphologic evaluation of pulmonary radiofrequency ablation

Risk factors for local progression after percutaneous radiofrequency ablation of lung tumors

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