Radiolabelled nanoparticles: novel classification of radiopharmaceuticals for molecular imaging of cancer

Abstract

Nanotechnology has been used for every single modality in the molecular imaging arena for imaging purposes. Synergic advantages can be explored when multiple molecular imaging modalities are combined with respect to single imaging modalities. Multifunctional nanoparticles have large surface areas, where multiple functional moieties can be incorporated, including ligands for site-specific targeting and radionuclides, which can be detected to create 3D images. Recently, radiolabeled nanoparticles with individual properties have attracted great interest regarding their use in multimodality tumor imaging. Multifunctional nanoparticles can combine diagnostic and therapeutic capabilities for both target-specific diagnosis and the treatment of a given disease. The future of nanomedicine lies in multifunctional nanoplatforms that combine the diagnostic ability and therapeutic effects using appropriate ligands, drugs, responses and technological devices, which together are collectively called theranostic drugs. Co-delivery of radiolabeled nanoparticles is useful in multifunctional molecular imaging areas because it comprises several advantages based on nanoparticles architecture, pharmacokinetics and pharmacodynamic properties.

68 Ga-Radiolabeled AGuIX Nanoparticles as Dual-Modality Imaging Agents for PET/MRI-Guided Radiation Therapy

“…In general, for successful translation of a radiolabeled imaging agent to the clinical, it is very important to evaluate the degree to which the association between the radioactive label and the core molecule remains intact in vivo [25,32]. In our case, it is critical to assess the stability of radiolabeled NPs, once administered into systemic circulation.…”

Hydroxyapatite and Titanium Dioxide Nanoparticles: Radiolabelling and In Vitro Stability of Prospective Theranostic Nanocarriers for 223Ra and 99mTc

“…The progress in the development of nanomaterial technology has a significant influence on all scientific and everyday life applications [ 1 , 2 ]. The massive expansion of nanomaterials is also seen in medicine, such as in bandages with antimicrobial nanosilver or with antibiotic capsules and nanoparticles (NPs), which are applicable for delivering drugs, light, heat, etc.…”

Synthesis, characterization and radiolabeling of polymeric nano-micelles as a platform for tumor delivering

“…PMs might exhibit high payloads of therapeutic and diagnostic agents. Additionally, their surface can be functionalized with different varieties of ligands, such as chelating agents for 99m Tc [27,28], making possible the early diagnosis, evaluation of the tumor burden and monitoring antitumor treatment progression [7,29]. Our group has previously described the use of DTPA onto the surface of silica nanoparticles as a means to achieve high radiolabeling yields 2 .…”