Radiolabeled Silicon-Rhodamines as Bimodal PET/SPECT-NIR Imaging Agents

Kanagasundaram, Thines; Laube, Markus; Wodtke, Johanna; Kramer, Carsten S.; Stadlbauer, Sven; Pietzsch, Jens; Kopka, Klaus

doi:10.3390/ph14111155

Cited by 4 publications

(2 citation statements)

References 91 publications

(150 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The combination of FI and NMI can overcome the obstacles of single modality imaging, allowing imaging with little radiation burden and unlimited penetration depth. For the construction of the bimodal probes in FI/NMI, however, the direct use of radiolabeled fluorescent dyes lack clear targeting sites ( Kanagasundaram et al, 2021 ; Peng et al, 2021 ). In this context, modified molecular probes and passively accumulated nanoparticles have been attributed to implement specific tumor uptake.…”

Section: Bimodal Imaging Of Tumor Based On Near-infrared-i Fluorescencementioning

confidence: 99%

NIR-I Dye-Based Probe: A New Window for Bimodal Tumor Theranostics

et al. 2022

View full text Add to dashboard Cite

Near-infrared (NIR, 650–1700 nm) bioimaging has emerged as a powerful strategy in tumor diagnosis. In particular, NIR-I fluorescence imaging (650–950 nm) has drawn more attention, benefiting from the high quantum yield and good biocompatibility. Since their biomedical applications are slightly limited by their relatively low penetration depth, NIR-I fluorescence imaging probes have been under extensive development in recent years. This review summarizes the particular application of the NIR-I fluorescent dye-contained bimodal probes, with emphasis on related nanoprobes. These probes have enabled us to overcome the drawbacks of individual imaging modalities as well as achieve synergistic imaging. Meanwhile, the application of these NIR-I fluorescence-based bimodal probes for cancer theranostics is highlighted.

show abstract

Section: Bimodal Imaging Of Tumor Based On Near-infrared-i Fluorescencementioning

confidence: 99%

NIR-I Dye-Based Probe: A New Window for Bimodal Tumor Theranostics

et al. 2022

View full text Add to dashboard Cite

show abstract

“…= 648 nm, λ em. = 667 nm) with lower masses compared to other NIR BODIPY-derived dyes [ 14 ]. Other work proved that triazole-fused SiR is capable of chelating technetium-99m, resulting in a SPECT-activable NIR dye [ 99m Tc] 6 [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Efforts toward PET-Activatable Red-Shifted Silicon Rhodamines and Silicon Pyronine Dyes

et al. 2023

Self Cite

View full text Add to dashboard Cite

Tracers for bimodal optical imaging and positron emission tomography unite multiple advantages in a single molecule. Their tumor-specific uptake can be visualized after their PET activation by radiofluorination via PET/CT or PET/MRI allowing for staging or therapy planning, while their non-radioactive moiety additionally facilitates the visualization of malignant tissue during intraoperative fluorescence-guided surgery or in histological assessments. The silicon-bridged xanthene core offers the opportunity for radiofluorination with SiFA isotope exchange to obtain a small-molecule, PET-activatable NIR dye that can be linked to different target vectors. Herein, we demonstrate for the first time the PET-activation of a fluorinated silicon pyronine, belonging to a class of low-molecular-weight fluorescence dyes with a large Stokes shift (up to 129 nm) and solvent-dependent NIR dye properties, with a successful radiochemical conversion of 70%. The non-fluorinated pyronine precursor is easily accessible by a three-step sequence from commercially starting material with a 12% overall yield. Moreover, a library of seven unusually functionalized (by approximately 15 nm), red-shifted silicon rhodamines were synthesized in three- to four-step sequences and the optical properties of the novel dyes were characterized. It was also shown that the synthesized silicon rhodamine dyes can be easily conjugated by amide bond formation or ‘click-reaction’ approaches.

show abstract