Radiolabeled multi-layered coated gold nanoparticles as potential biocompatible PET/SPECT tracers

Uritu, Cristina M.; Al-Matarneh, Cristina M.; Bostiog, Denisse I.; Coroaba, Adina; Ghizdovat, Vlad; Filipiuc, Silviu I.; Simionescu, Natalia; Stefanescu, Cipriana; Jalloul, Wael; Nastasa, Valentin; Tamba, Bogdan I.; Maier, Stelian S.; Pinteala, Mariana

doi:10.1039/d3tb02654j

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2024

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Cited by 3 publications

References 75 publications

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Recent advances in the detection and quantification of manufactured nanoparticles (MNPs) in complex environmental and biological matrices

Abbas,

Zia-ur-Rehman,

Ullah

et al. 2024

Journal of Cleaner Production

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Recent advances in the detection and quantification of manufactured nanoparticles (MNPs) in complex environmental and biological matrices

Abbas,

Zia-ur-Rehman,

Ullah

et al. 2024

Journal of Cleaner Production

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Multi-shell gold nanoparticles functionalized with methotrexate: a novel nanotherapeutic approach for improved antitumoral and antioxidant activity and enhanced biocompatibility

Bostiog,

Simionescu,

Coroaba

et al. 2024

Drug Delivery

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Methotrexate (MTX) is a folic acid antagonist routinely used in cancer treatment, characterized by poor water solubility and low skin permeability. These issues could be mitigated by using drug delivery systems, such as functionalized gold nanoparticles (AuNPs), known for their versatility and unique properties. This study aimed to develop multi-shell AuNPs functionalized with MTX for the improvement of MTX antitumoral, antioxidant, and biocompatibility features. Stable phosphine-coated AuNPs were synthesized and functionalized with tailored polyethylene glycol (PEG) and short-branched polyethyleneimine (PEI) moieties, followed by MTX covalent binding. Physicochemical characterization by UV–vis and Fourier-transform infrared spectroscopy (FTIR) spectroscopy, dynamic light scattering (DLS), scanning transmission electron microscopy (STEM), and X-ray photoelectron spectroscopy (XPS) confirmed the synthesis at each step. The antioxidant activity of functionalized AuNPs was determined using DPPH radical scavenging assay, ferric ions’ reducing antioxidant power (FRAP), and cupric reducing antioxidant capacity (CUPRAC) assays. Biocompatibility and cytotoxicity were assessed using MTT and LDH assays on HaCaT human keratinocytes and CAL27 squamous cell carcinoma. MTX functionalized AuNPs demonstrated enhanced antioxidant activity and a pronounced cytotoxic effect on the tumoral cells compared to their individual components, highlighting their potential for improving cancer therapy.

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In-vivo demonstration of activation imaging of gold nanoparticles

Koshikawa,

Kikuchi,

Tanaka

et al. 2024

2024 IEEE Nuclear Science Symposium (NSS), Medical Imaging Conference (MIC) and Room Temperature Semiconductor Detector Confere

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Radiolabeled multi-layered coated gold nanoparticles as potential biocompatible PET/SPECT tracers

Abstract: The demand for tailored, disease-adapted, and easily accessible radiopharmaceuticals is one of the most persistent in nuclear imaging precision medicine. The aim of this work was to develop two multimodal...

Cited by 3 publications

References 75 publications

Recent advances in the detection and quantification of manufactured nanoparticles (MNPs) in complex environmental and biological matrices

Recent advances in the detection and quantification of manufactured nanoparticles (MNPs) in complex environmental and biological matrices

Multi-shell gold nanoparticles functionalized with methotrexate: a novel nanotherapeutic approach for improved antitumoral and antioxidant activity and enhanced biocompatibility

In-vivo demonstration of activation imaging of gold nanoparticles

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