Radioisotope bone scanning for the detection of occult bony metastases in invasive cervical carcinoma

Toit, J. P. Du; Med, M.; Grové, D.

doi:10.1016/0090-8258(87)90216-2

Cited by 7 publications

(6 citation statements)

References 6 publications

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“…There is a uniformly low incidence of true-positives, particularly in stage I and II disease. False-positives were more frequent [4,5,8]. The 2.5% incidence of skeletal metastases reported by one author [6] in stage I disease is explained by the fact that scans were performed up to 42 months after the initial diagnosis.…”

Section: Discussionmentioning

confidence: 71%

“…This is the same order of magnitude as is found in our own material (1/8). In up to 39.5% cases [8], no pathological changes were found by X-ray examination of scan-positive bones. Among 1,252 patients with cervical cancer, 55 developed bone metastases, but only in one case was this diagnosis made at the time of initial staging [1].…”

Section: Discussionmentioning

confidence: 85%

“…A relatively high incidence of bone metastases is found only in patients with recurrent disease, and about 10% of scans for bone metastases are positive in this group [4,8]. Such patients should always have a body scan.…”

Section: Discussionmentioning

confidence: 92%

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Indications for radioisotope bone scanning in staging of cervical cancer

Hirnle

Mittmann

Schmidt

et al. 1990

Arch Gynecol Obstet

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The total of 160 patients with newly diagnosed invasive cancer of the cervix had whole body radioisotope bone scanning during staging of their disease. 51 patients had cancer of the cervix stage I, 63 had stage II, 34 stage III and 12 stage IV (FIGO). Only in 8 of 160 patients did the bone scans indicate possible metastases and this was confirmed by X-ray examination in only one patient with stage IV disease and liver metastases. We conclude that patients with stage I and stage II carcinoma of the cervix do not need to have bone scans.

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Section: Discussionmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 85%

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Indications for radioisotope bone scanning in staging of cervical cancer

Hirnle

Mittmann

Schmidt

et al. 1990

Arch Gynecol Obstet

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“…There were fewer patients with bone involvement at diagnosis (1.56%; 10/642 patients) than previously reported at Tygerberg Hospital (2.03%) or at Johannesburg General Hospital (4.6%). 4,5 These are both historical studies published prior to the implementation of routine 10-yearly Papanicolaou smears in South Africa and this could partly be the reason why women in these earlier studies presented with more advanced disease.…”

Section: Discussionmentioning

confidence: 99%

“…3 Two South African studies, the first of radiographic findings on 1 347 women at cervical cancer diagnosis at Johannesburg General Hospital and the second at Tygerberg Hospital, investigating the detection of bone metastases by bone scan in 540 patients, gave prevalences of bony involvement at diagnosis of 4.6% and 2.03% respectively. 4,5 A higher rate of bone involvement was reported at an autopsy study in all gynaecological cancers. 6 Of the 112 cervical cancer patients who were autopsied, 20 (17.9%) were found to have bony involvement.…”

Section: Introductionmentioning

confidence: 93%

Bone involvement in patients with cervical carcinoma: a single-institution cohort study

Butt

Botha

2019

Southern African Journal of Gynaecological Oncology

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Bony metastases in cervical carcinoma are rare; however, autopsy studies indicate that they are underdiagnosed. A retrospective study was undertaken to describe the risk factors and tumour characteristics and estimate the prevalence of bone involvement in women with cervical cancer at a tertiary institution in South Africa. Methods: A retrospective cohort analysis of women with cervical cancer diagnosed between 2014 and 2015 was undertaken. Demographic, treatment and follow-up data were collected for all women with bone metastases confirmed by imaging. Descriptive statistics were generated. Results: The study identified 642 patients with cervical carcinoma, of whom 25 (3.89%) were diagnosed with bone involvement. Ten women had bone involvement at diagnosis and 15 women at recurrence, occurring a median of 286 days after primary treatment. Survival after the diagnosis of bone metastases was short, with 88% of patients dying within six months. The WHO performance status score at diagnosis was a significant predictor of survival (p = 0.024). A prognostic score was utilised and those with a high score had a significantly shorter survival (median 61 days) than those with a low score (median 158 days) (p = 0.0065). Conclusions: Although bone metastases are rare in women with cervical cancer, they are important to recognise. Healthcare workers should be vigilant regarding increased analgesic use and chronic pain, as these may indicate bone involvement. As survival is short, a prognostic score is valuable in tailoring treatment. A patient's quality of life may be greatly improved by an appropriate radiotherapy and palliative care plan.

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The Bone Scan in Metastatic Disease

Fogelman¹,

McKillop²

1991

Bone Metastases

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Radioisotope bone scanning for the detection of occult bony metastases in invasive cervical carcinoma

Cited by 7 publications

References 6 publications

Indications for radioisotope bone scanning in staging of cervical cancer

Indications for radioisotope bone scanning in staging of cervical cancer

Bone involvement in patients with cervical carcinoma: a single-institution cohort study

The Bone Scan in Metastatic Disease

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