Radioiodine Treatment of Basedow's Disease: Interference and Influence Factors, Risk Estimation

Reiners, Chr.

doi:10.1055/s-0029-1211078

Cited by 12 publications

(2 citation statements)

References 18 publications

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“…The authors suggested that hypometabolism, due to the hypothyroidism induced by PTU, could be the mechanism of such radioprotection (24). Some authors reported a radioprotective effect of antithyroid compounds in patients undergoing radioiodine treatment, although the effect could be related to a reduction of intrathyroid iodine half life due to a direct inhibition of thyroperoxidase (25)(26)(27). Also, a possible interaction of MMI with the sodium iodide symporter may not be ruled out.…”

Section: Discussionmentioning

confidence: 99%

Protection against Radiation-Induced Damage of 6-Propyl-2-thiouracil (PTU) in Thyroid Cells

et al. 2013

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Many epidemiologic studies have shown that the exposure to high external radiation doses increases thyroid neoplastic frequency, especially when given during childhood or adolescence. The use of radioprotective drugs may decrease the damage caused by radiation therapy and therefore could be useful to prevent the development of thyroid tumors. The aim of this study was to investigate the possible application of 6-propyl-2-thiouracil (PTU) as a radioprotector in the thyroid gland. Rat thyroid epithelial cells (FRTL-5) were exposed to different doses of γ irradiation with or without the addition of PTU, methimazole (MMI), reduced glutathione (GSH) and perchlorate (KClO4). Radiation response was analyzed by clonogenic survival assay. Cyclic AMP (cAMP) levels were measured by radioimmunoassay (RIA). Apoptosis was quantified by nuclear cell morphology and caspase 3 activity assays. Intracellular reactive oxygen species (ROS) levels were measured using the fluorescent dye 2',7'-dichlorofluorescein-diacetate. Catalase, superoxide dismutase and glutathione peroxidase activities were also determined. Pretreatment with PTU, MMI and GSH prior to irradiation significantly increased the surviving cell fraction (SF) at 2 Gy (P < 0.05), while no effect was observed with KClO4. An increase in extracellular levels of cAMP was found only in PTU treated cells in a dose and time-dependent manner. Cells incubated with agents that stimulate cAMP (forskolin and dibutyril cAMP) mimicked the effect of PTU on SF. Moreover, pretreatment with the inhibitor of protein kinase A, H-89, abolished the radioprotective effect of PTU. PTU treatment diminished radiation-induced apoptosis and protected cells against radiation-induced ROS elevation and suppression of the antioxidant enzyme's activity. PTU was found to radioprotect normal thyroid cells through cAMP elevation and reduction in both apoptosis and radiation-induced oxidative stress damage.

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Section: Discussionmentioning

confidence: 99%

Protection against Radiation-Induced Damage of 6-Propyl-2-thiouracil (PTU) in Thyroid Cells

et al. 2013

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“…Allerdings sind in der Literatur auch gegenteilige Beobachtungen vermerkt (Allahabadia et al 2001;Pfeilschifter et al 1997;Vogt et al 2006). (Peters et al 1995;Reiners 1991;Sabri et al 1999) Der Verlauf der TSH-Rezeptorautoantikörper in den ersten 6 Monaten nach RIT zeigte in der vorliegenden Arbeit ein aus der Literatur gut bekanntes Phänomen.…”

Section: Zahlreiche Studie Belegen Keine Einflussnahme Der Prätherape...unclassified

Präradiotherapeutische Dosimetrie mittels einer einzigen Uptake-Messung

Appold¹

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The incidence of recurrence and hypothyroidism after radioiodine treatment in patients with hyperthyroidism in Trakya, a mild iodine deficiency area, during the period 1991–2003

et al. 2005

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The treatment success in all groups and subgroups did not differ significantly between FD and CD. Our lower cure rate than in previous studies may be related to iodine deficiency. Higher doses of radioiodine may be required to increase final treatment success in endemic goiter areas. If this true, dosimetry and calculated dose regimen would be required in all groups of patients instead of an FD concept. However, our findings should be verified in larger series of patients, with longer follow-up period, and urinary iodine concentration measurements.

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Radioiodine Treatment of Basedow's Disease: Interference and Influence Factors, Risk Estimation

Cited by 12 publications

References 18 publications

Protection against Radiation-Induced Damage of 6-Propyl-2-thiouracil (PTU) in Thyroid Cells

Protection against Radiation-Induced Damage of 6-Propyl-2-thiouracil (PTU) in Thyroid Cells

Präradiotherapeutische Dosimetrie mittels einer einzigen Uptake-Messung

The incidence of recurrence and hypothyroidism after radioiodine treatment in patients with hyperthyroidism in Trakya, a mild iodine deficiency area, during the period 1991–2003

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