Radioiodine therapy of benign thyroid disorders: what are the effective thyroidal half-life and uptake of 131I?

Abstract

These actual values analyzed here might be used for a semi-individual calculation of therapeutic activity when an individual approach is not possible.

Development of hypothyroidism during long‐term follow‐up of patients with toxic nodular goitre after radioiodine therapy

“…Therapeutic activity was calculated following the procedure guidelines for the preliminary radioiodine test with an intended dose of 150 Gy 23 . After oral application of radioiodine therapy, the therapeutically achieved dose was calculated on the basis of serial uptake measurements twice a day over 4–5 days as previously described 16,24 …”

“…23 After oral application of radioiodine therapy, the therapeutically achieved dose was calculated on the basis of serial uptake measurements twice a day over 4-5 days as previously described. 16,24 Patient outcome and follow-up…”

Determining thyroid131I effective half-life for the treatment planning of Graves’ disease

“…However, the difference among T eff values reported in the current literature might be explained by the methodology employed for the calculation and the group of patients enrolled in each study, since 131 I pharmacokinetics varies according to many factors, such as the thyroid disease itself, disease staging, previous administration of antithyroid drug medication, and the amount of actually functioning thyroid tissue. 11,12 Due to the appreciable T eff variability, the application of a general mean value of T eff is not advisable, when estimating the specific radiation dose in personalized therapy, since application would imply inadequacy to the true exposure received by a specific patient. This could even lead to under-or overdosing of patients in targeted therapies based on dosimetry, to the extent of producing an incorrect dose versus biological effect relationship.…”

Radiation Safety Precautions in 131I Therapy of Graves' Disease Based on Actual Biokinetic Measurements

“…In 131 I therapy of GD, a good intraindividual agreement on thyroid iodine uptake has been documented between testing and therapy (22). As such, we used testing measurements to predict thyroid iodine uptake during therapy.…”